ARGJ_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARGJ_YEAST
• UniProt AC: Q04728
• Protein Name: Arginine biosynthesis bifunctional protein ArgJ, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03124}
• Gene Name: ARG7 {ECO:0000255|HAMAP-Rule:MF_03124}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 441
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate..
• Protein Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Acetylation	KYALYVPKTGSFPKG HEEEEECCCCCCCCC	56.31	24489116
46	Phosphorylation	SGVKKNGSLDLGVIL CCCCCCCEEEEEEEE	28.27	22369663
55	Phosphorylation	DLGVILNTNKSRPST EEEEEEECCCCCCCC	40.35	22369663
58	Phosphorylation	VILNTNKSRPSTAAA EEEECCCCCCCCEEE	52.04	22369663
61	Phosphorylation	NTNKSRPSTAAAVFT ECCCCCCCCEEEEEE	29.57	22369663
62	Phosphorylation	TNKSRPSTAAAVFTT CCCCCCCCEEEEEEC	24.01	22369663
68	Phosphorylation	STAAAVFTTNKFKAA CCEEEEEECCCCCCC	23.90	22369663
69	Phosphorylation	TAAAVFTTNKFKAAP CEEEEEECCCCCCCC	25.58	22369663
90	Acetylation	VLETARGKNINAIVV HHHHHCCCCCEEEEE	49.45	24489116
124	Acetylation	MIDLVNDKIGQKNST HHHHHCCCCCCCCCE	43.46	24489116
147	Acetylation	GQRLQMDKISTGINK HHHHCHHHHCCCHHH	32.96	24489116
154	Acetylation	KISTGINKIFGEEKF HHCCCHHHHHCCCHH	37.18	24489116
190	Acetylation	KLVTSRFKLPSGTEY HHHEECCCCCCCCEE	59.38	22865919
233	Acetylation	IESKALQKMLTFATT CCCHHHHHHHHHHHC	36.41	24489116
236	Phosphorylation	KALQKMLTFATTRSF HHHHHHHHHHHCCCC	14.02	27017623
253	Phosphorylation	ISVDGDMSTNDTICM EEEECCCCCCCEEEH	28.88	27017623
257	Phosphorylation	GDMSTNDTICMLANG CCCCCCCEEEHHCCC	20.39	27017623
268	Phosphorylation	LANGAIDTKEINEDS HCCCCCCHHHCCCCC	25.18	27017623
275	Phosphorylation	TKEINEDSKDFEQVK HHHCCCCCCCHHHHH	28.13	27017623
276	Acetylation	KEINEDSKDFEQVKL HHCCCCCCCHHHHHH	77.94	24489116
276	Succinylation	KEINEDSKDFEQVKL HHCCCCCCCHHHHHH	77.94	23954790
282	Acetylation	SKDFEQVKLQVTEFA CCCHHHHHHHHHHHH	32.66	24489116
355	Acetylation	LCAIGYAKLNDLKSL HHHHHCHHHHCCCCC	39.06	24489116
360	Acetylation	YAKLNDLKSLDVNKI CHHHHCCCCCCCCEE	52.41	24489116
360	Succinylation	YAKLNDLKSLDVNKI CHHHHCCCCCCCCEE	52.41	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARGJ_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARGJ_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARGJ_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN1_YEAST	CAN1	genetic	16941010
GAP1_YEAST	GAP1	genetic	16941010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.