| UniProt ID | RPB3_YEAST | |
|---|---|---|
| UniProt AC | P16370 | |
| Protein Name | DNA-directed RNA polymerase II subunit RPB3 | |
| Gene Name | RPB3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 318 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination.. | |
| Protein Sequence | MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVIVSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPYSNASQMGNTGSGGYDNAW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEEGPQVK ------CCCCCCCCE | 44.34 | 22814378 | |
| 23 | Phosphorylation | DNVDFILSNVDLAMA CCCCCHHHCHHHHHH | 29.95 | 22369663 | |
| 32 | Phosphorylation | VDLAMANSLRRVMIA HHHHHHHHHHHHHEE | 17.45 | 22369663 | |
| 137 | Acetylation | GHPIIQDKEGNGVLI CCCEEECCCCCEEEE | 51.66 | 24489116 | |
| 199 | Ubiquitination | WYEQDSAKEWPQSKN CCCCCCCCCCCCCCC | 65.35 | 22817900 | |
| 199 | Acetylation | WYEQDSAKEWPQSKN CCCCCCCCCCCCCCC | 65.35 | 24489116 | |
| 257 | Phosphorylation | TLQKKVASILLALTQ HHHHHHHHHHHHHHC | 19.43 | 24603354 | |
| 263 | Phosphorylation | ASILLALTQMDQDKV HHHHHHHHCCCHHHC | 19.08 | 28889911 | |
| 274 | Phosphorylation | QDKVNFASGDNNTAS HHHCCCCCCCCCHHH | 42.41 | 28889911 | |
| 279 | Phosphorylation | FASGDNNTASNMLGS CCCCCCCHHHHHCCC | 37.40 | 28889911 | |
| 281 | Phosphorylation | SGDNNTASNMLGSNE CCCCCHHHHHCCCCC | 22.27 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPB3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPB3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPB3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
