| UniProt ID | MOT3_YEAST | |
|---|---|---|
| UniProt AC | P54785 | |
| Protein Name | Transcriptional activator/repressor MOT3 | |
| Gene Name | MOT3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 490 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter).. | |
| Protein Sequence | MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSNTNNIGSDSLASQPFNTTTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNNNNVTAGNNMSASPIVHNNSNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHPNQFTAAANMNSNAAAAAYYSFPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNNAANNGSNNSSHSAPAPAPGPPHHHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQFQLQQNPSPNLNLNINPAQPLHLPPGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNLVPAPSSDHKYIHQCQFCEKSFKRKSWLKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQHMKLKHTNYLLDELKKNNIIFNYNNSSSSNNNNDNNNNNNSNSASGSGGAGAAAAAATAPENEDGNGYDTNIKTLINDGVLNKDDVKRVLNNLIVSHNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MNADHHLQ -------CCHHHHHH | 9.35 | 22814378 | |
| 343 | Ubiquitination | PAPSSDHKYIHQCQF CCCCCCCCCHHHCCC | 51.39 | 17644757 | |
| 353 | Ubiquitination | HQCQFCEKSFKRKSW HHCCCCCHHHHCCHH | 63.47 | 17644757 | |
| 384 | Ubiquitination | PWCLSRQKRKDNLLQ HHHHCHHHHHHHHHH | 61.37 | 17644757 | |
| 386 | Ubiquitination | CLSRQKRKDNLLQHM HHCHHHHHHHHHHHH | 58.99 | 17644757 | |
| 394 | Ubiquitination | DNLLQHMKLKHTNYL HHHHHHHHHHHHHHH | 52.86 | 17644757 | |
| 396 | Ubiquitination | LLQHMKLKHTNYLLD HHHHHHHHHHHHHHH | 42.75 | 17644757 | |
| 406 | Ubiquitination | NYLLDELKKNNIIFN HHHHHHHHHCCEEEE | 51.94 | 17644757 | |
| 407 | Ubiquitination | YLLDELKKNNIIFNY HHHHHHHHCCEEEEC | 68.78 | 17644757 | |
| 464 | Ubiquitination | NGYDTNIKTLINDGV CCCCCCHHHHHCCCC | 39.07 | 17644757 | |
| 474 | Ubiquitination | INDGVLNKDDVKRVL HCCCCCCHHHHHHHH | 51.66 | 17644757 | |
| 474 | Acetylation | INDGVLNKDDVKRVL HCCCCCCHHHHHHHH | 51.66 | 24489116 | |
| 478 | Ubiquitination | VLNKDDVKRVLNNLI CCCHHHHHHHHHHHH | 43.73 | 17644757 | |
| 490 | Ubiquitination | NLIVSHNK------- HHHHCCCC------- | 57.18 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOT3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOT3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOT3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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