| UniProt ID | SAC7_YEAST | |
|---|---|---|
| UniProt AC | P17121 | |
| Protein Name | GTPase-activating protein SAC7 | |
| Gene Name | SAC7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 654 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | GTPase-activating protein for RHO1. Must be involved in the normal assembly or function or both of actin. Plays an essential role only at low temperatures.. | |
| Protein Sequence | MPNNTLKQGSKIENVSPSKGHVPSFWKQFINNPKSMSSENITVPRSPTSLSRNAQPTTLKRPPLSSRPYSYNTPTKDRKSFSKSAKQNNNNNNANSGTSPHAEFKNYRDMFLSNRNGFTGRVFGVTLAESLSVASAEVIVQSELVSFGRIPIVVAKCGAYLKANGLETSGIFRIAGNGKRVKALQYIFSSPPDYGTKFNDWETYTVHDVASLLRRYLNNLAEPLIPLSLYEQFRNPLRSRPRILRHMLTHEVSHPNANKTNNVTVKSSRQNYNDDGANDGDIEKEDAKDDEEKRRRKIRHKRRLTRDIRAAIKEYEELFVTLSNDTKQLTIYLLDLLSLFARQSQFNLMSGRNLAAIFQPSILSHPQHDMDPKEYELSRLVVEFLIEYSYKLLPHLLKLAKREQQERLSTENKKNNGDKQKTDPIEIPKITSSDSPPIVSSNKNPPAIDNNNKLDHTTLSPISTSIPENSSDLQTSKMLKPPKQRRPHSKSFGSTPVPPDVIASNKRRTSLFPWLHKPGILSDTGDNGDLTATEAEGDDYEEENVDPYGQSPSSVHSGSLPKQHYLPIPRMNRSLSGNSTNSSFNTRPISMILTSGNDNSADQLELLSNTHSNNERSNALPLTEDDGDERNSRSRKRESWFQRLTSRSGSANRA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | NNTLKQGSKIENVSP CCCCCCCCCCCCCCC | 28.15 | 28889911 | |
| 16 | Phosphorylation | GSKIENVSPSKGHVP CCCCCCCCCCCCCCC | 34.73 | 25521595 | |
| 18 | Phosphorylation | KIENVSPSKGHVPSF CCCCCCCCCCCCCHH | 43.70 | 22890988 | |
| 27 | Acetylation | GHVPSFWKQFINNPK CCCCHHHHHHHCCCC | 33.06 | 24489116 | |
| 35 | Phosphorylation | QFINNPKSMSSENIT HHHCCCCCCCCCCCC | 25.75 | 22369663 | |
| 37 | Phosphorylation | INNPKSMSSENITVP HCCCCCCCCCCCCCC | 41.41 | 22369663 | |
| 38 | Phosphorylation | NNPKSMSSENITVPR CCCCCCCCCCCCCCC | 26.48 | 22369663 | |
| 42 | Phosphorylation | SMSSENITVPRSPTS CCCCCCCCCCCCCCC | 35.72 | 20377248 | |
| 46 | Phosphorylation | ENITVPRSPTSLSRN CCCCCCCCCCCCCCC | 26.85 | 22369663 | |
| 48 | Phosphorylation | ITVPRSPTSLSRNAQ CCCCCCCCCCCCCCC | 43.47 | 22369663 | |
| 49 | Phosphorylation | TVPRSPTSLSRNAQP CCCCCCCCCCCCCCC | 27.94 | 22369663 | |
| 51 | Phosphorylation | PRSPTSLSRNAQPTT CCCCCCCCCCCCCCC | 24.21 | 22369663 | |
| 57 | Phosphorylation | LSRNAQPTTLKRPPL CCCCCCCCCCCCCCC | 32.45 | 19823750 | |
| 58 | Phosphorylation | SRNAQPTTLKRPPLS CCCCCCCCCCCCCCC | 36.64 | 19823750 | |
| 66 | Phosphorylation | LKRPPLSSRPYSYNT CCCCCCCCCCCCCCC | 44.98 | 27017623 | |
| 69 | Phosphorylation | PPLSSRPYSYNTPTK CCCCCCCCCCCCCCC | 23.76 | 29136822 | |
| 70 | Phosphorylation | PLSSRPYSYNTPTKD CCCCCCCCCCCCCCC | 18.00 | 24930733 | |
| 71 | Phosphorylation | LSSRPYSYNTPTKDR CCCCCCCCCCCCCCH | 19.74 | 20377248 | |
| 73 | Phosphorylation | SRPYSYNTPTKDRKS CCCCCCCCCCCCHHH | 24.89 | 29136822 | |
| 80 | Phosphorylation | TPTKDRKSFSKSAKQ CCCCCHHHHHHHHHH | 35.33 | 28889911 | |
| 82 | Phosphorylation | TKDRKSFSKSAKQNN CCCHHHHHHHHHHCC | 32.56 | 28889911 | |
| 84 | Phosphorylation | DRKSFSKSAKQNNNN CHHHHHHHHHHCCCC | 39.23 | 28889911 | |
| 96 | Phosphorylation | NNNNNANSGTSPHAE CCCCCCCCCCCCCHH | 40.83 | 24909858 | |
| 98 | Phosphorylation | NNNANSGTSPHAEFK CCCCCCCCCCCHHHH | 38.62 | 22369663 | |
| 99 | Phosphorylation | NNANSGTSPHAEFKN CCCCCCCCCCHHHHC | 20.43 | 22369663 | |
| 107 | Phosphorylation | PHAEFKNYRDMFLSN CCHHHHCHHHHHHHC | 14.47 | 28889911 | |
| 266 | Ubiquitination | KTNNVTVKSSRQNYN CCCCEEEEECCCCCC | 33.09 | 23749301 | |
| 267 | Phosphorylation | TNNVTVKSSRQNYND CCCEEEEECCCCCCC | 26.81 | 23749301 | |
| 284 | Ubiquitination | ANDGDIEKEDAKDDE CCCCCCCHHHCCCHH | 62.32 | 22106047 | |
| 431 | Phosphorylation | PIEIPKITSSDSPPI CCCCCCCCCCCCCCC | 28.45 | 22369663 | |
| 432 | Phosphorylation | IEIPKITSSDSPPIV CCCCCCCCCCCCCCC | 35.30 | 22369663 | |
| 433 | Phosphorylation | EIPKITSSDSPPIVS CCCCCCCCCCCCCCC | 33.20 | 22369663 | |
| 435 | Phosphorylation | PKITSSDSPPIVSSN CCCCCCCCCCCCCCC | 34.23 | 22369663 | |
| 440 | Phosphorylation | SDSPPIVSSNKNPPA CCCCCCCCCCCCCCC | 28.98 | 22369663 | |
| 441 | Phosphorylation | DSPPIVSSNKNPPAI CCCCCCCCCCCCCCC | 40.71 | 22369663 | |
| 457 | Phosphorylation | NNNKLDHTTLSPIST CCCCCCCCCCCCCCC | 29.15 | 22369663 | |
| 458 | Phosphorylation | NNKLDHTTLSPISTS CCCCCCCCCCCCCCC | 23.09 | 22369663 | |
| 460 | Phosphorylation | KLDHTTLSPISTSIP CCCCCCCCCCCCCCC | 20.35 | 22369663 | |
| 463 | Phosphorylation | HTTLSPISTSIPENS CCCCCCCCCCCCCCC | 21.34 | 20377248 | |
| 464 | Phosphorylation | TTLSPISTSIPENSS CCCCCCCCCCCCCCC | 31.25 | 22369663 | |
| 465 | Phosphorylation | TLSPISTSIPENSSD CCCCCCCCCCCCCCC | 29.38 | 20377248 | |
| 470 | Phosphorylation | STSIPENSSDLQTSK CCCCCCCCCCCCHHC | 24.46 | 20377248 | |
| 471 | Phosphorylation | TSIPENSSDLQTSKM CCCCCCCCCCCHHCC | 54.65 | 22369663 | |
| 475 | Phosphorylation | ENSSDLQTSKMLKPP CCCCCCCHHCCCCCC | 37.30 | 22369663 | |
| 476 | Phosphorylation | NSSDLQTSKMLKPPK CCCCCCHHCCCCCCC | 11.78 | 22369663 | |
| 489 | Phosphorylation | PKQRRPHSKSFGSTP CCCCCCCCCCCCCCC | 32.45 | 21082442 | |
| 491 | Phosphorylation | QRRPHSKSFGSTPVP CCCCCCCCCCCCCCC | 37.54 | 22369663 | |
| 494 | Phosphorylation | PHSKSFGSTPVPPDV CCCCCCCCCCCCHHH | 27.77 | 25371407 | |
| 495 | Phosphorylation | HSKSFGSTPVPPDVI CCCCCCCCCCCHHHH | 28.78 | 22890988 | |
| 522 | Phosphorylation | LHKPGILSDTGDNGD HCCCCCCCCCCCCCC | 31.07 | 21440633 | |
| 524 | Phosphorylation | KPGILSDTGDNGDLT CCCCCCCCCCCCCCC | 42.96 | 21551504 | |
| 531 | Phosphorylation | TGDNGDLTATEAEGD CCCCCCCCEEEEECC | 35.95 | 21551504 | |
| 533 | Phosphorylation | DNGDLTATEAEGDDY CCCCCCEEEEECCCC | 30.41 | 21440633 | |
| 548 | Phosphorylation | EEENVDPYGQSPSSV CCCCCCCCCCCCCCC | 24.27 | 19823750 | |
| 551 | Phosphorylation | NVDPYGQSPSSVHSG CCCCCCCCCCCCCCC | 23.53 | 21440633 | |
| 553 | Phosphorylation | DPYGQSPSSVHSGSL CCCCCCCCCCCCCCC | 50.68 | 21551504 | |
| 554 | Phosphorylation | PYGQSPSSVHSGSLP CCCCCCCCCCCCCCC | 27.51 | 21440633 | |
| 557 | Phosphorylation | QSPSSVHSGSLPKQH CCCCCCCCCCCCCCC | 28.11 | 20377248 | |
| 559 | Phosphorylation | PSSVHSGSLPKQHYL CCCCCCCCCCCCCCC | 44.50 | 19823750 | |
| 574 | Phosphorylation | PIPRMNRSLSGNSTN CCCCCCCCCCCCCCC | 23.14 | 28889911 | |
| 576 | Phosphorylation | PRMNRSLSGNSTNSS CCCCCCCCCCCCCCC | 36.86 | 28889911 | |
| 582 | Phosphorylation | LSGNSTNSSFNTRPI CCCCCCCCCCCCCCC | 36.07 | 28889911 | |
| 600 | Phosphorylation | LTSGNDNSADQLELL EECCCCCCHHHHHHH | 35.77 | 21440633 | |
| 623 | Phosphorylation | RSNALPLTEDDGDER CCCCCCCCCCCCCCC | 35.11 | 22369663 | |
| 632 | Phosphorylation | DDGDERNSRSRKRES CCCCCCCHHHHHHHH | 37.54 | 22369663 | |
| 639 | Phosphorylation | SRSRKRESWFQRLTS HHHHHHHHHHHHHHH | 36.90 | 25704821 | |
| 646 | Phosphorylation | SWFQRLTSRSGSANR HHHHHHHHCCCCCCC | 29.10 | 21082442 | |
| 648 | Phosphorylation | FQRLTSRSGSANRA- HHHHHHCCCCCCCC- | 36.55 | 17563356 | |
| 650 | Phosphorylation | RLTSRSGSANRA--- HHHHCCCCCCCC--- | 24.50 | 17563356 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAC7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SAC7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAC7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; SER-99; SER-435;SER-491; SER-600 AND SER-632, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-648 AND SER-650,AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-491, AND MASSSPECTROMETRY. | |
