| UniProt ID | GLU2A_YEAST | |
|---|---|---|
| UniProt AC | P38138 | |
| Protein Name | Glucosidase 2 subunit alpha | |
| Gene Name | ROT2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 954 | |
| Subcellular Localization | Endoplasmic reticulum . | |
| Protein Description | Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.. | |
| Protein Sequence | MVLLKWLVCQLVFFTAFSHAFTDYLLKKCAQSGFCHRNRVYAENIAKSHHCYYKVDAESIAHDPLENVLHATIIKTIPRLEGDDIAVQFPFSLSFLQDHSVRFTINEKERMPTNSSGLLISSQRFNETWKYAFDKKFQEEANRTSIPQFHFLKQKQTVNSFWSKISSFLSLSNSTADTFHLRNGDVSVEIFAEPFQLKVYWQNALKLIVNEQNFLNIEHHRTKQENFAHVLPEETTFNMFKDNFLYSKHDSMPLGPESVALDFSFMGSTNVYGIPEHATSLRLMDTSGGKEPYRLFNVDVFEYNIGTSQPMYGSIPFMFSSSSTSIFWVNAADTWVDIKYDTSKNKTMTHWISENGVIDVVMSLGPDIPTIIDKFTDLTGRPFLPPISSIGYHQCRWNYNDEMDVLTVDSQMDAHMIPYDFIWLDLEYTNDKKYFTWKQHSFPNPKRLLSKLKKLGRNLVVLIDPHLKKDYEISDRVINENVAVKDHNGNDYVGHCWPGNSIWIDTISKYGQKIWKSFFERFMDLPADLTNLFIWNDMNEPSIFDGPETTAPKDLIHDNYIEERSVHNIYGLSVHEATYDAIKSIYSPSDKRPFLLTRAFFAGSQRTAATWTGDNVANWDYLKISIPMVLSNNIAGMPFIGADIAGFAEDPTPELIARWYQAGLWYPFFRAHAHIDTKRREPYLFNEPLKSIVRDIIQLRYFLLPTLYTMFHKSSVTGFPIMNPMFIEHPEFAELYHIDNQFYWSNSGLLVKPVTEPGQSETEMVFPPGIFYEFASLHSFINNGTDLIEKNISAPLDKIPLFIEGGHIITMKDKYRRSSMLMKNDPYVIVIAPDTEGRAVGDLYVDDGETFGYQRGEYVETQFIFENNTLKNVRSHIPENLTGIHHNTLRNTNIEKIIIAKNNLQHNITLKDSIKVKKNGEESSLPTRSSYENDNKITILNLSLDITEDWEVIF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 114 | N-linked_Glycosylation | EKERMPTNSSGLLIS CCCCCCCCCCCEEEE | 28.45 | - | |
| 126 | N-linked_Glycosylation | LISSQRFNETWKYAF EEEEHHHCHHHHHHH | 48.23 | - | |
| 142 | N-linked_Glycosylation | KKFQEEANRTSIPQF HHHHHHHHCCCCCCH | 51.55 | - | |
| 153 | Acetylation | IPQFHFLKQKQTVNS CCCHHHHCCHHHHHH | 55.28 | 24489116 | |
| 173 | N-linked_Glycosylation | SSFLSLSNSTADTFH HHHHHCCCCCCCEEE | 48.99 | - | |
| 345 | N-linked_Glycosylation | IKYDTSKNKTMTHWI EEEECCCCCEEEEEE | 44.81 | - | |
| 516 | Acetylation | KYGQKIWKSFFERFM HHHHHHHHHHHHHHC | 40.64 | 24489116 | |
| 783 | N-linked_Glycosylation | SLHSFINNGTDLIEK HHHHHHHCCCHHHHH | 50.34 | - | |
| 791 | N-linked_Glycosylation | GTDLIEKNISAPLDK CCHHHHHCCCCCHHH | 22.21 | - | |
| 867 | N-linked_Glycosylation | ETQFIFENNTLKNVR EEEEEEECCCHHHHH | 35.72 | - | |
| 880 | N-linked_Glycosylation | VRSHIPENLTGIHHN HHHHCCCCCCCCCCC | 37.23 | - | |
| 907 | N-linked_Glycosylation | AKNNLQHNITLKDSI EECCCCCCEEECCCE | 18.91 | - | |
| 924 | Phosphorylation | KKNGEESSLPTRSSY ECCCCCCCCCCCCCC | 41.47 | 19779198 | |
| 941 | N-linked_Glycosylation | DNKITILNLSLDITE CCCEEEEEEEEECCC | 24.59 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLU2A_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLU2A_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLU2A_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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