| UniProt ID | GLU2B_YEAST | |
|---|---|---|
| UniProt AC | Q04924 | |
| Protein Name | Glucosidase 2 subunit beta | |
| Gene Name | GTB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 702 | |
| Subcellular Localization | Endoplasmic reticulum . | |
| Protein Description | Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Specifically required for the cleavage of the final glucose.. | |
| Protein Sequence | MVSMFSLFLLLIEQSPLVASLQQSQRHIVGVPWEKQHLYDSNEPDLTKWHCLNHEDIVLDISQINDGVCDCPDGSDEPGSAACVEDIFKSVAEGGGKVNKYFYCDNKGFIPRYIRKSEVADGICDCCDCSDELLSGYELFDAGSNCSQLKNEFDIMASKELSSYREGKEALEELERKYGTKEEAITRGNCLEEDKEKASAEIKVLSNRLSENRAKLEQLRGEYFNQLSHDPILYQFEQLNSTRLGSDILTSFTMVSRVSKGYQDIFKILSDLSEAYTPSLNDKVVNDNIKKFRKVRRRAEKAKINADSKIDDEQADNLYLYFTEEVPQIFLKRESENTLRYVIGKSNFVQALVEGKINYTNDILEYIREFRLIMDDISQNYNVNFQDAGVKSAVDSYKNYLGEYGELAELEPAHPSESLLRSLSEVTSFVNENAPKVLPPDAVESEQDTNSDHIGTSGDLRNKLKEILSKLNIFSSRKDLVSLEKRFRSCESQVSLLENELKQKMDYKKLLDETEDEGTNSTAGNLTELLELMGSQSYCLDDILDNYVYTICFQRPMTEGVIYQAEDKVDGKKVLIGRFKTSGFNVDLNMEKYAEHLKATYDEKSDLISNLAAIQDDDGNMQHYVFGNLNELNNGLVLEYENGDQCWNGPRRSATVFVRCSDKFKIRSVHEATKCNYIFDVVGPLGCNKTFEYEPPKFNLSE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Acetylation | IVGVPWEKQHLYDSN CCCCCHHHHCCCCCC | 38.87 | 24489116 | |
| 113 | Phosphorylation | NKGFIPRYIRKSEVA CCCCCCCCCCHHHCC | 10.34 | 19779198 | |
| 117 | Phosphorylation | IPRYIRKSEVADGIC CCCCCCHHHCCCCCC | 27.70 | 19779198 | |
| 145 | N-linked_Glycosylation | ELFDAGSNCSQLKNE EEEECCCCHHHHHHH | 28.65 | - | |
| 240 | N-linked_Glycosylation | LYQFEQLNSTRLGSD HHHHHHHCCCCCCHH | 40.82 | - | |
| 246 | Phosphorylation | LNSTRLGSDILTSFT HCCCCCCHHHHHHHH | 26.52 | 30377154 | |
| 253 | Phosphorylation | SDILTSFTMVSRVSK HHHHHHHHHHHCCCC | 19.21 | 30377154 | |
| 358 | N-linked_Glycosylation | ALVEGKINYTNDILE HHHCCCCCCHHHHHH | 40.85 | - | |
| 520 | N-linked_Glycosylation | ETEDEGTNSTAGNLT HCCCCCCCCCCCCHH | 48.50 | - | |
| 525 | N-linked_Glycosylation | GTNSTAGNLTELLEL CCCCCCCCHHHHHHH | 41.13 | - | |
| 688 | N-linked_Glycosylation | VVGPLGCNKTFEYEP ECCCCCCCCCCCCCC | 44.60 | - | |
| 699 | N-linked_Glycosylation | EYEPPKFNLSE---- CCCCCCCCCCC---- | 49.10 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLU2B_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLU2B_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLU2B_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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