HRD3_YEAST - dbPTM
HRD3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HRD3_YEAST
UniProt AC Q05787
Protein Name ERAD-associated E3 ubiquitin-protein ligase component HRD3
Gene Name HRD3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 833
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of missfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M. Stabilizes the HRD1 ubiquitin-protein ligase. Has also a function in recruiting misfolded protein substrates..
Protein Sequence MITLLLYLCVICNAIVLIRADSIADPWPEARHLLNTIAKSRDPMKEAAMEPNADEFVGFYVPMDYSPRNEEKNYQSIWQNEITDSQRHIYELLVQSSEQFNNSEATYTLSQIHLWSQYNFPHNMTLAHKYLEKFNDLTHFTNHSAIFDLAVMYATGGCASGNDQTVIPQDSAKALLYYQRAAQLGNLKAKQVLAYKYYSGFNVPRNFHKSLVLYRDIAEQLRKSYSRDEWDIVFPYWESYNVRISDFESGLLGKGLNSVPSSTVRKRTTRPDIGSPFIAQVNGVQMTLQIEPMGRFAFNGNDGNINGDEDDEDASERRIIRIYYAALNDYKGTYSQSRNCERAKNLLELTYKEFQPHVDNLDPLQVFYYVRCLQLLGHMYFTGEGSSKPNIHMAEEILTTSLEISRRAQGPIGRACIDLGLINQYITNNISQAISYYMKAMKTQANNGIVEFQLSKLATSFPEEKIGDPFNLMETAYLNGFIPAIYEFAVMIESGMNSKSSVENTAYLFKTFVDKNEAIMAPKLRTAFAALINDRSEVALWAYSQLAEQGYETAQVSAAYLMYQLPYEFEDPPRTTDQRKTLAISYYTRAFKQGNIDAGVVAGDIYFQMQNYSKAMALYQGAALKYSIQAIWNLGYMHEHGLGVNRDFHLAKRYYDQVSEHDHRFYLASKLSVLKLHLKSWLTWITREKVNYWKPSSPLNPNEDTQHSKTSWYKQLTKILQRMRHKEDSDKAAEDSHKHRTVVQNGANHRGDDQEEASEILGFQMEDLVTMGCILGIFLLSILMSTLAARRGWNVRFNGAQLNANGNRQQEQQQQQQAQGPPGWDFNVQIFAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39UbiquitinationHLLNTIAKSRDPMKE
HHHHHHHHCCCHHHH		42.0217644757
65PhosphorylationGFYVPMDYSPRNEEK
EEECCCCCCCCCHHC		17.8327017623
66PhosphorylationFYVPMDYSPRNEEKN
EECCCCCCCCCHHCC		17.0827017623
72UbiquitinationYSPRNEEKNYQSIWQ
CCCCCHHCCHHHHHH		55.5717644757
101N-linked_GlycosylationVQSSEQFNNSEATYT
HHCHHHHCCCCCEEE		51.30-
123N-linked_GlycosylationSQYNFPHNMTLAHKY
HHCCCCCCCHHHHHH		25.93-
142N-linked_GlycosylationNDLTHFTNHSAIFDL
CCCCCCCCHHHHHHH		26.60-
188UbiquitinationAAQLGNLKAKQVLAY
HHHCCCCCHHHHHHH		58.5023749301
254UbiquitinationFESGLLGKGLNSVPS
HCCCCCCCCCCCCCC		61.2617644757
331UbiquitinationYAALNDYKGTYSQSR
HHHHHCCCCCCCCCC		47.8717644757
333PhosphorylationALNDYKGTYSQSRNC
HHHCCCCCCCCCCCC		18.8227017623
334PhosphorylationLNDYKGTYSQSRNCE
HHCCCCCCCCCCCCH		17.2427017623
335PhosphorylationNDYKGTYSQSRNCER
HCCCCCCCCCCCCHH		22.8627017623
337PhosphorylationYKGTYSQSRNCERAK
CCCCCCCCCCCHHHH		21.3727017623
344UbiquitinationSRNCERAKNLLELTY
CCCCHHHHHHHHHHH		55.1117644757
352UbiquitinationNLLELTYKEFQPHVD
HHHHHHHHHHHCCCC		46.9817644757
429N-linked_GlycosylationINQYITNNISQAISY
HHHHHHCCHHHHHHH		27.00-
499UbiquitinationIESGMNSKSSVENTA
HHCCCCCCCCHHHHH		41.5717644757
510UbiquitinationENTAYLFKTFVDKNE
HHHHHHHHHHHCCCC		38.1617644757
523AcetylationNEAIMAPKLRTAFAA
CCCCCCHHHHHHHHH		40.8524489116
611N-linked_GlycosylationDIYFQMQNYSKAMAL
HHHHHCCCHHHHHHH		37.39-
714AcetylationHSKTSWYKQLTKILQ
CCHHHHHHHHHHHHH		32.3524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HRD3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HRD3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HRD3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HMDH2_YEASTHMG2physical
11390656
HMDH1_YEASTHMG1physical
11390656
HRD1_YEASTHRD1physical
11018054
GRP78_YEASTKAR2physical
10547371
CDC48_YEASTCDC48physical
16619026
HRD1_YEASTHRD1physical
16619026
CBPY_YEASTPRC1physical
16619026
HRD1_YEASTHRD1genetic
16873065
OS9_YEASTYOS9physical
16845381
IRE1_YEASTIRE1genetic
16269340
TSC3_YEASTTSC3genetic
16269340
HAC1_YEASTHAC1genetic
16269340
BIG1_YEASTBIG1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
COG3_YEASTCOG3genetic
16269340
SEC22_YEASTSEC22genetic
16269340
PFD2_YEASTGIM4genetic
16269340
MON2_YEASTMON2genetic
16269340
ALG5_YEASTALG5genetic
16269340
ICE2_YEASTICE2genetic
16269340
EMC5_YEASTEMC5genetic
16269340
GPI8_YEASTGPI8genetic
16269340
AP3M_YEASTAPM3genetic
16269340
SCS7_YEASTSCS7genetic
16269340
RIC1_YEASTRIC1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
ATC6_YEASTSPF1physical
16093310
OAC1_YEASTOAC1physical
16093310
YNJ5_YEASTYNL095Cphysical
16093310
UBC7_YEASTUBC7genetic
10547371
CUE1_YEASTCUE1genetic
10547371
PSB4_YEASTPRE1genetic
10547371
PSB5_YEASTPRE2genetic
10547371
CUE1_YEASTCUE1genetic
19325107
DER1_YEASTDER1genetic
19325107
HRD1_YEASTHRD1genetic
19325107
SPT4_YEASTSPT4genetic
19325107
UBC7_YEASTUBC7genetic
19325107
USA1_YEASTUSA1genetic
19325107
LCL2_YEASTLCL2genetic
19325107
OS9_YEASTYOS9genetic
19325107
CALX_YEASTCNE1genetic
19325107
CWH41_YEASTCWH41genetic
19325107
FKH1_YEASTFKH1genetic
19325107
GDA1_YEASTGDA1genetic
19325107
GLU2B_YEASTGTB1genetic
19325107
KRE1_YEASTKRE1genetic
19325107
LEM3_YEASTLEM3genetic
19325107
MSC1_YEASTMSC1genetic
19325107
RER1_YEASTRER1genetic
19325107
GLU2A_YEASTROT2genetic
19325107
VPS3_YEASTVPS3genetic
19325107
VPS74_YEASTVPS74genetic
19325107
YUR1_YEASTYUR1genetic
19325107
HRD1_YEASTHRD1genetic
21074049
USA1_YEASTUSA1genetic
19940128
DFM1_YEASTDFM1physical
20579315
HRD1_YEASTHRD1physical
20005842
USA1_YEASTUSA1physical
20005842
CDC48_YEASTCDC48physical
20005842
UBX2_YEASTUBX2physical
20005842
CDC48_YEASTCDC48physical
19696741
HRD1_YEASTHRD1physical
19696741
SC61A_YEASTSEC61physical
19696741
VPS54_YEASTVPS54genetic
21987634
RGP1_YEASTRGP1genetic
21987634
DOP1_YEASTDOP1genetic
21987634
VPS52_YEASTVPS52genetic
21987634
HAC1_YEASTHAC1genetic
21987634
IRE1_YEASTIRE1genetic
21987634
BIG1_YEASTBIG1genetic
21987634
ICE2_YEASTICE2genetic
21987634
PLMT_YEASTOPI3genetic
21987634
ILM1_YEASTILM1genetic
21987634
UBI4P_YEASTUBI4genetic
21987634
RIC1_YEASTRIC1genetic
21987634
ERG3_YEASTERG3physical
21737688
OS9_YEASTYOS9physical
22262864
OS9_YEASTYOS9physical
25428985
HRD1_YEASTHRD1physical
25428985
USA1_YEASTUSA1physical
25428985
UBX2_YEASTUBX2physical
25428985
SCJ1_YEASTSCJ1physical
25428985
GRP78_YEASTKAR2physical
25428985
STT3_YEASTSTT3genetic
27708008
FAL1_YEASTFAL1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
CDC1_YEASTCDC1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
MED6_YEASTMED6genetic
27708008
GRP78_YEASTKAR2genetic
27708008
ARP4_YEASTARP4genetic
27708008
ROT1_YEASTROT1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
HRD1_YEASTHRD1genetic
27170191
IRE1_YEASTIRE1genetic
26184977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HRD3_YEAST

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Related Literatures of Post-Translational Modification

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