| UniProt ID | MON2_YEAST | |
|---|---|---|
| UniProt AC | P48563 | |
| Protein Name | Protein MON2 | |
| Gene Name | MON2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1636 | |
| Subcellular Localization |
Golgi apparatus membrane Peripheral membrane protein . Late Golgi. |
|
| Protein Description | Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure.. | |
| Protein Sequence | MAMNTGGFDSMQRQLEAELRSLSSESKRRNSTIRHASDKSIEILKRVHSFEELERHPDFALPFVLACQSRNAKMTTLAMQCLQGLSTVPSIPRSRLSEILDAFIEATHLAMEIQLKVLQVVPIFFKTYGKFIYGPLCKKLLLCCSNLLHVPNKAPVVVGTASATLQQLIDEIFDRLSIESVVDDKQYEVLISNSESIKVNVYRYDANKLFDNICSLNEISSNGAVSDEEMLLDIGDIPIDYGLEILESILKNSQKNLLECQDLQYLLRVKAIPLLLRCISSSRHFSTAVRSCRCLKLLIRKEYLSILELELEVILSLLIHGISVESNLSGWQRVLSLELFKDLSQDPEIVNTLYMDYDNYPDKKHVFKYLLKECIVLLNSPEYITFLAPSKVVEKMDSPLITTENSTVKTKFMHLLDKSNAPSINITYIISLILTICNHLCEGLNKSALESSPLEKKIEDKEREEGTGNDSTVVKVYSGLFSGLFELNKLFLYSTSLETSIFHLVVRAFQKLAHSAGVLSLKDKLRACMKLFSILITNNVTSSNQYSFNDTSKSAKNQHTRNISTSSVTTSPVESTKNPSRSIADSAQNKEMKRRLHPRNISSRQVSLLRALISLSISLGPIFDSESWRYTFLTWQWITYYIYGPSADFKESFYSEDIPPPPILTKSDVTSIESSLTKFFESTSSYSCSTFHLVLTRLILDSKNTLTLEQTNLNLNNDIGYHPLDAKDEIIPCIYNKAFFVNKIGELATYNCKKFLFGKNGKELWSLISTYMIKLISNREMDNDSLRLYTVRVFTDIIKKATNEVGNSDEQDNKVKQFGTLENLVIDSLMATINSIKQLDIGKQEIYNGTINVESDILFQLLLTLKEILNEFGELLMNSWTNIFNIINSPFEWTVEDTDFSVNEDIDDSSLFEGIVQKHKNMIQVSYDVFKLISDDFLQSLPMSVIKFVIDTLVNFVSQKRNLNISFSSISQFWLVGDYLRVRFNPETLNLSDEKRRSLSEKINNQKLIEIITSSSSHDWELYNGLWIYLLKNLINCTNDDRVEVKNGAVQTFFRIIDSHSVCFPPWDLIFLEVIEPLLTKEWSTEELENETDFINVTLQGLIKLYPEHFKDFKNNTTCAKEWSMLLDFLKRLLSSTSNNTKNAVILNYQTLLKEIITIEDVPSDILKKCCEIFTDYNITYSDLSTNASSKTEYDCIYELITGFPPLYQLISKYDAMTDEFVEKVLLLFNSAIKYPLLPEFVQDKTKPSSMQKAILSGLDIFMTNDSKDTEILILLQLSTISILAFDTREKITKKLGPKLPKASLNRLPTFEAISYMSCSNLRNRIAKIDQFGISTLKAKHILRILKNLAEIIKRKSLITGSESDEIPIWVLASNCFCDLSNKIFKSLQEDAENPLKDNFCDLFINVIVVTLQRINPELDNLTEIDDLNEYSKYREILLENRIIDLFNERQLDTFIYAVWDCSFLYEFDELENALMQDCGTFSELSQKLSSFDFSCIFGSTTNPRFQTKYKCSLECLQDLVNFMLNTNEKLRKLTAPYLSARIALALRRYISDEYLIGRAPIPKLRKTELATLLNGLCVILRGVLDQNSTLGNKQIGVENLQTLSPLILRTIPVSHKMDGLQDKVLELSLGFTKLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAMNTGGFD ------CCCCCCCHH | 15.96 | 22814378 | |
| 23 | Phosphorylation | EAELRSLSSESKRRN HHHHHHCCHHHHHHH | 33.05 | 30377154 | |
| 49 | Phosphorylation | EILKRVHSFEELERH HHHHHCCCHHHHHHC | 31.34 | 28889911 | |
| 180 | Phosphorylation | FDRLSIESVVDDKQY HHHCCCEEECCCCCE | 26.27 | 27017623 | |
| 192 | Phosphorylation | KQYEVLISNSESIKV CCEEEEECCCCCEEE | 30.09 | 27017623 | |
| 398 | Phosphorylation | KVVEKMDSPLITTEN HHHHCCCCCCEECCC | 20.36 | 23749301 | |
| 452 | Phosphorylation | NKSALESSPLEKKIE CHHHHHCCCCHHHHC | 24.91 | 30377154 | |
| 515 | Phosphorylation | AFQKLAHSAGVLSLK HHHHHHHHCCCCCHH | 22.55 | 28889911 | |
| 560 | Phosphorylation | KSAKNQHTRNISTSS HHHCCCCCCCEECCC | 18.69 | 21440633 | |
| 564 | Phosphorylation | NQHTRNISTSSVTTS CCCCCCEECCCCCCC | 26.28 | 22369663 | |
| 565 | Phosphorylation | QHTRNISTSSVTTSP CCCCCEECCCCCCCC | 22.63 | 22369663 | |
| 566 | Phosphorylation | HTRNISTSSVTTSPV CCCCEECCCCCCCCC | 18.93 | 22369663 | |
| 567 | Phosphorylation | TRNISTSSVTTSPVE CCCEECCCCCCCCCC | 24.46 | 22369663 | |
| 569 | Phosphorylation | NISTSSVTTSPVEST CEECCCCCCCCCCCC | 24.41 | 22369663 | |
| 570 | Phosphorylation | ISTSSVTTSPVESTK EECCCCCCCCCCCCC | 28.95 | 22369663 | |
| 571 | Phosphorylation | STSSVTTSPVESTKN ECCCCCCCCCCCCCC | 19.99 | 22369663 | |
| 575 | Phosphorylation | VTTSPVESTKNPSRS CCCCCCCCCCCCCCC | 44.94 | 22369663 | |
| 576 | Phosphorylation | TTSPVESTKNPSRSI CCCCCCCCCCCCCCH | 22.72 | 22369663 | |
| 577 | Ubiquitination | TSPVESTKNPSRSIA CCCCCCCCCCCCCHH | 75.93 | 23749301 | |
| 580 | Phosphorylation | VESTKNPSRSIADSA CCCCCCCCCCHHHHH | 48.32 | 22369663 | |
| 582 | Phosphorylation | STKNPSRSIADSAQN CCCCCCCCHHHHHCC | 26.85 | 21551504 | |
| 586 | Phosphorylation | PSRSIADSAQNKEMK CCCCHHHHHCCHHHH | 23.80 | 21551504 | |
| 631 | Phosphorylation | DSESWRYTFLTWQWI CCCCHHEEEEEEEEE | 12.00 | 27017623 | |
| 634 | Phosphorylation | SWRYTFLTWQWITYY CHHEEEEEEEEEEEE | 16.06 | 27017623 | |
| 640 | Phosphorylation | LTWQWITYYIYGPSA EEEEEEEEEHHCCCH | 4.44 | 27017623 | |
| 643 | Phosphorylation | QWITYYIYGPSADFK EEEEEEHHCCCHHHH | 13.58 | 27017623 | |
| 646 | Phosphorylation | TYYIYGPSADFKESF EEEHHCCCHHHHHHH | 35.79 | 27017623 | |
| 677 | Phosphorylation | TSIESSLTKFFESTS CCHHHHHHHHHHHCC | 27.96 | 21440633 | |
| 814 | Ubiquitination | NSDEQDNKVKQFGTL CCHHHCCHHHHHCCH | 60.13 | 23749301 | |
| 820 | Phosphorylation | NKVKQFGTLENLVID CHHHHHCCHHHHHHH | 31.99 | 19823750 | |
| 828 | Phosphorylation | LENLVIDSLMATINS HHHHHHHHHHHHHHH | 14.66 | 19823750 | |
| 832 | Phosphorylation | VIDSLMATINSIKQL HHHHHHHHHHHHHHC | 13.51 | 19823750 | |
| 835 | Phosphorylation | SLMATINSIKQLDIG HHHHHHHHHHHCCCC | 27.58 | 19823750 | |
| 934 | Phosphorylation | YDVFKLISDDFLQSL HHHHHHHCHHHHHHC | 41.38 | 19823750 | |
| 940 | Phosphorylation | ISDDFLQSLPMSVIK HCHHHHHHCCHHHHH | 36.27 | 19823750 | |
| 944 | Phosphorylation | FLQSLPMSVIKFVID HHHHCCHHHHHHHHH | 20.81 | 19823750 | |
| 1231 | Phosphorylation | KVLLLFNSAIKYPLL HHHHHHHHCCCCCCC | 24.84 | 21126336 | |
| 1347 | Acetylation | KHILRILKNLAEIIK HHHHHHHHHHHHHHH | 47.76 | 22865919 | |
| 1594 | Ubiquitination | QNSTLGNKQIGVENL CCCCCCCCCCCCCCH | 41.30 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MON2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MON2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MON2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564; THR-565; SER-567;THR-569 AND SER-571, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564 AND SER-567, ANDMASS SPECTROMETRY. | |
