| UniProt ID | MPS1_YEAST | |
|---|---|---|
| UniProt AC | P54199 | |
| Protein Name | Serine/threonine-protein kinase MPS1 | |
| Gene Name | MPS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 764 | |
| Subcellular Localization | ||
| Protein Description | Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues. Phosphorylates the SPC29 and SPC110 spindle pole body components.. | |
| Protein Sequence | MSTNSFHDYVDLKSRTNTRQFSDDEEFTTPPKLSNFGSALLSHTEKTSASEILSSHNNDKIANRLEEMDRSSSRSHPPPSMGNLTSGHTSTSSHSTLFGRYLRNNHQTSMTTMNTSDIEINVGNSLDKSFERIRNLRQNMKEDITAKYAERRSKRFLISNRTTKLGPAKRAMTLTNIFDEDVPNSPNQPINARETVELPLEDSHQTNFKETKRNTDYDSIDFGDLNPIQYIKKHNLPTSDLPLISQIYFDKQREENRQAALRKHSSRELLYKSRSSSSSLSSNNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRRALKENIDTSNNSNFNSPIHKIYKGISRNKDSDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNENINSKNLEVFYHRPAPKPPVTKKVEIVEPAKSASLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGSGNRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQKRVIQLLDYEMGDGLLYLIMECGDHDLSQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFLQPFMISGSIMEDLIRNAVRYGSEKPHISQDDLNDVVDTVLRKFADYKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSTNSFHDY ------CCCCCCHHH | 35.97 | 24961812 | |
| 3 | Phosphorylation | -----MSTNSFHDYV -----CCCCCCHHHC | 33.32 | 24961812 | |
| 5 | Phosphorylation | ---MSTNSFHDYVDL ---CCCCCCHHHCCC | 24.85 | 24961812 | |
| 22 | Phosphorylation | RTNTRQFSDDEEFTT CCCCCCCCCCCCCCC | 35.49 | 28889911 | |
| 28 | Phosphorylation | FSDDEEFTTPPKLSN CCCCCCCCCCCCCCC | 41.49 | 28889911 | |
| 29 | Phosphorylation | SDDEEFTTPPKLSNF CCCCCCCCCCCCCCH | 42.80 | 28889911 | |
| 32 | Ubiquitination | EEFTTPPKLSNFGSA CCCCCCCCCCCHHHH | 66.79 | 17644757 | |
| 38 | Phosphorylation | PKLSNFGSALLSHTE CCCCCHHHHHHHHCC | 16.17 | 28889911 | |
| 42 | Phosphorylation | NFGSALLSHTEKTSA CHHHHHHHHCCCCCH | 29.25 | 28889911 | |
| 44 | Phosphorylation | GSALLSHTEKTSASE HHHHHHHCCCCCHHH | 35.48 | 24961812 | |
| 46 | Ubiquitination | ALLSHTEKTSASEIL HHHHHCCCCCHHHHH | 49.27 | 17644757 | |
| 47 | Phosphorylation | LLSHTEKTSASEILS HHHHCCCCCHHHHHH | 24.24 | 28889911 | |
| 48 | Phosphorylation | LSHTEKTSASEILSS HHHCCCCCHHHHHHH | 40.65 | 28889911 | |
| 50 | Phosphorylation | HTEKTSASEILSSHN HCCCCCHHHHHHHCC | 25.57 | 21440633 | |
| 54 | Phosphorylation | TSASEILSSHNNDKI CCHHHHHHHCCCHHH | 34.90 | 28889911 | |
| 55 | Phosphorylation | SASEILSSHNNDKIA CHHHHHHHCCCHHHH | 27.13 | 28889911 | |
| 60 | Ubiquitination | LSSHNNDKIANRLEE HHHCCCHHHHHHHHH | 45.93 | 17644757 | |
| 71 | Phosphorylation | RLEEMDRSSSRSHPP HHHHHHHHHCCCCCC | 28.53 | 28889911 | |
| 72 | Phosphorylation | LEEMDRSSSRSHPPP HHHHHHHHCCCCCCC | 30.57 | 28889911 | |
| 115 | Phosphorylation | TSMTTMNTSDIEINV CCCEEECHHHCEEEC | 19.56 | 28889911 | |
| 116 | Phosphorylation | SMTTMNTSDIEINVG CCEEECHHHCEEECC | 31.42 | 28889911 | |
| 145 | Phosphorylation | QNMKEDITAKYAERR HHHHHHHHHHHHHHH | 29.44 | 28889911 | |
| 173 | Phosphorylation | GPAKRAMTLTNIFDE CHHHHHHHHHCCCCC | 29.46 | 28889911 | |
| 175 | Phosphorylation | AKRAMTLTNIFDEDV HHHHHHHHCCCCCCC | 19.66 | 28889911 | |
| 185 | Phosphorylation | FDEDVPNSPNQPINA CCCCCCCCCCCCCCC | 21.11 | 28889911 | |
| 195 | Phosphorylation | QPINARETVELPLED CCCCCCCEEECCCCH | 17.46 | 28889911 | |
| 203 | Phosphorylation | VELPLEDSHQTNFKE EECCCCHHCCCCCCC | 14.23 | 23749301 | |
| 232 | Ubiquitination | LNPIQYIKKHNLPTS CCHHHHHHHCCCCCC | 42.94 | 17644757 | |
| 233 | Ubiquitination | NPIQYIKKHNLPTSD CHHHHHHHCCCCCCC | 28.32 | 17644757 | |
| 238 | Phosphorylation | IKKHNLPTSDLPLIS HHHCCCCCCCCCCCH | 37.73 | 28889911 | |
| 251 | Ubiquitination | ISQIYFDKQREENRQ CHHHHHHHHHHHHHH | 41.16 | 17644757 | |
| 281 | Phosphorylation | RSSSSSLSSNNLLAN CCCCCCCCCCCCCCC | 32.73 | 21440633 | |
| 292 | Phosphorylation | LLANKDNSITSNNGS CCCCCCCCCCCCCCC | 37.06 | 22369663 | |
| 294 | Phosphorylation | ANKDNSITSNNGSQP CCCCCCCCCCCCCCC | 25.81 | 22369663 | |
| 295 | Phosphorylation | NKDNSITSNNGSQPR CCCCCCCCCCCCCCC | 26.99 | 28889911 | |
| 299 | Phosphorylation | SITSNNGSQPRRKVS CCCCCCCCCCCEEEE | 38.85 | 28889911 | |
| 312 | Phosphorylation | VSTGSSSSKSSIEIR EECCCCCCHHHHHHH | 38.21 | 28889911 | |
| 315 | Phosphorylation | GSSSSKSSIEIRRAL CCCCCHHHHHHHHHH | 28.16 | 28889911 | |
| 329 | Phosphorylation | LKENIDTSNNSNFNS HHHHCCCCCCCCCCC | 30.21 | 28889911 | |
| 332 | Phosphorylation | NIDTSNNSNFNSPIH HCCCCCCCCCCCHHH | 47.23 | 21440633 | |
| 336 | Phosphorylation | SNNSNFNSPIHKIYK CCCCCCCCHHHHHHH | 22.54 | 23749301 | |
| 353 | Phosphorylation | SRNKDSDSEKREVLR HCCCCCHHHHHHHHH | 49.31 | 28889911 | |
| 363 | Phosphorylation | REVLRNISINANHAD HHHHHHHHCCCCHHH | 17.22 | 28889911 | |
| 383 | Phosphorylation | ENKRLKRSLDDAITN HHHHHHHHHHHHHHC | 34.26 | 28889911 | |
| 389 | Phosphorylation | RSLDDAITNENINSK HHHHHHHHCCCCCCC | 37.89 | 21440633 | |
| 395 | Phosphorylation | ITNENINSKNLEVFY HHCCCCCCCCEEEEE | 21.08 | 21440633 | |
| 396 | Ubiquitination | TNENINSKNLEVFYH HCCCCCCCCEEEEEE | 62.15 | 17644757 | |
| 412 | Phosphorylation | PAPKPPVTKKVEIVE CCCCCCCCCEEEEEC | 30.81 | 28889911 | |
| 423 | Phosphorylation | EIVEPAKSASLSNNR EEECCCCCCCCCCCC | 25.79 | 28889911 | |
| 468 | 2-Hydroxyisobutyrylation | GNRVYALKRVSFDAF CCEEEEEEEEEECCC | 42.45 | - | |
| 471 | Phosphorylation | VYALKRVSFDAFDDS EEEEEEEEECCCCCC | 22.80 | 28889911 | |
| 478 | Phosphorylation | SFDAFDDSSIDGFKG EECCCCCCCCCCCHH | 30.91 | 28889911 | |
| 577 | Ubiquitination | VLVKGILKIIDFGIA EEEECHHHHHHHHHH | 35.38 | 17644757 | |
| 591 | Phosphorylation | ANAVPEHTVNIYRET HCCCCCCCEEEEHHC | 17.37 | 28889911 | |
| 617 | Phosphorylation | ALVAMNYTQNSENQH HHHHCCCCCCCCCCC | 19.10 | 28889911 | |
| 679 | Phosphorylation | KIPFPEHTSNNEKIP CCCCCCCCCCCCCCC | 31.33 | 28889911 | |
| 694 | Ubiquitination | KSAIELMKACLYRNP HHHHHHHHHHHHHCC | 48.88 | 24961812 | |
| 703 | Ubiquitination | CLYRNPDKRWTVDKV HHHHCCCCCCCHHHH | 51.60 | 17644757 | |
| 754 | Phosphorylation | DLNDVVDTVLRKFAD HHHHHHHHHHHHHCC | 15.16 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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