ESL1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESL1_YEAST
• UniProt AC: P40456
• Protein Name: EST/SMG-like protein 1 {ECO:0000303|PubMed:23893744}
• Gene Name: ESL1 {ECO:0000303|PubMed:23893744}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1118
• Protein Description: May be involved in the regulation of gene expression responses of environment-sensing pathways..
• Protein Sequence: MVDLMVPANDDPSNETDYSRSNNNHTHIVSDMRPTSAAFLHQKRHSSSSHNDTPESSFAKRRVPGIVDPVGKGFIDGITNSQISAQNTPSKTDDASRRPSISRKVMESTPQVKTSSIPTMDVPKSPYYVNRTMLARNMKVVSRDTYEDNANPQMRADEPLVASNGIYSNSQPQSQVTLSDIRRAPVVAASPPPMIRQLPSAQPNQTFIKKLQEIYKIIVVQETELQQRCLYLTTSQTTELKSLWAIYRLNTELIKNYINFIITALLTTQPINDLIMGQEILDIYRIEKRLWVYGIITFLDVLKNFSNFMDPEVCCQFIIYAFISVSNMLEDIPLKYSILWRQRLGDLSRMAISLYPSGFIDWRLSAEYWYTESMKYIYGCGKLYYHIATVQQNSLEAFVNLGKSVFCQDPFTPSQQTLQLLIENIYQSAFIDRSSGSANNNEIAHRNSQLIDYLKHTEVMLLPSFLENMDLQHVVLMYFKDKFGKDFNGNDVFDTKDMFCQNPESLRYYFRHAPAFAESQLLQLIGFGNPKNPFALLFQLPKYLKLKKDKREKKRSEATETSSYTDPFDVQISSESYFQNIDALNSSFNDIPTNLNIWLDSLNHINMTSIQCSIHVLTKFLHAPLVVALPHFLTWLHFIVAILKKLEMVNSKQVVAFWIHFLRRTMPWNSIVTLGNVLVCYMLDNLHPFLKKELEKFYSLELDDLIEYYNENENLPEIWKCWGTLWFDAIKKCDVMEIPGVQDHLFFDSPLDGIVFDEKDEVGEKFWMRSVRAVLLLKGIAKKFPDLGLKVSFQASVFCRRNDIPPDYFLKNLTFKLDAYDEDNYNDNNELDDLYDTIEINEEIEAVNMDPQATPNLSVVSGESIFEYTGYTRLAPDYHCFDKNGGFNSAFIYSQWSNVGNGVTLDVSGESIYDVANNNLSLHWEKIFFDKIAAASKGSDENYNCTLYFVIDATSWLRHFAHIFKLAKNNTLKFAICLTTFQELRYLRGSKDDTVVEAATRSVITIRQLYDEKKIIPMRFTGNIATHVEENLEFEEQITWKTHVDEFVIDAIAKLNQRFQAERLTDENKNKGKEFAVLVTDDDNMNQKAKDRMIKTCNTKYLFSLGSKLGINSGLCTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	NDDPSNETDYSRSNN CCCCCCCCCCCCCCC		30377154
18	Phosphorylation	DPSNETDYSRSNNNH CCCCCCCCCCCCCCC		30377154
19	Phosphorylation	PSNETDYSRSNNNHT CCCCCCCCCCCCCCC		30377154
46	Phosphorylation	FLHQKRHSSSSHNDT HHHHHCCCCCCCCCC		21440633
47	Phosphorylation	LHQKRHSSSSHNDTP HHHHCCCCCCCCCCC		19823750
48	Phosphorylation	HQKRHSSSSHNDTPE HHHCCCCCCCCCCCH		21440633
49	Phosphorylation	QKRHSSSSHNDTPES HHCCCCCCCCCCCHH		21440633
53	Phosphorylation	SSSSHNDTPESSFAK CCCCCCCCCHHHHHH		28889911
56	Phosphorylation	SHNDTPESSFAKRRV CCCCCCHHHHHHHCC		19823750
57	Phosphorylation	HNDTPESSFAKRRVP CCCCCHHHHHHHCCC		19823750
84	Phosphorylation	GITNSQISAQNTPSK CCCHHCCCCCCCCCC		23749301
88	Phosphorylation	SQISAQNTPSKTDDA HCCCCCCCCCCCCCC		23749301
90	Phosphorylation	ISAQNTPSKTDDASR CCCCCCCCCCCCCCC		28889911
96	Phosphorylation	PSKTDDASRRPSISR CCCCCCCCCCCCHHH		21440633
100	Phosphorylation	DDASRRPSISRKVME CCCCCCCCHHHHHHH		17287358
102	Phosphorylation	ASRRPSISRKVMEST CCCCCCHHHHHHHCC		28889911
114	Phosphorylation	ESTPQVKTSSIPTMD HCCCCCCCCCCCCCC		24961812
115	Phosphorylation	STPQVKTSSIPTMDV CCCCCCCCCCCCCCC		24961812
116	Phosphorylation	TPQVKTSSIPTMDVP CCCCCCCCCCCCCCC		25752575
125	Phosphorylation	PTMDVPKSPYYVNRT CCCCCCCCCCCCCHH		22369663
127	Phosphorylation	MDVPKSPYYVNRTML CCCCCCCCCCCHHHH		22369663
128	Phosphorylation	DVPKSPYYVNRTMLA CCCCCCCCCCHHHHH		22369663
163	Phosphorylation	ADEPLVASNGIYSNS CCCCCEECCCCCCCC		22369663
167	Phosphorylation	LVASNGIYSNSQPQS CEECCCCCCCCCCCC		22369663
168	Phosphorylation	VASNGIYSNSQPQSQ EECCCCCCCCCCCCE		22369663
170	Phosphorylation	SNGIYSNSQPQSQVT CCCCCCCCCCCCEEE		22369663
174	Phosphorylation	YSNSQPQSQVTLSDI CCCCCCCCEEEHHHH		22369663
177	Phosphorylation	SQPQSQVTLSDIRRA CCCCCEEEHHHHHHC		23749301
179	Phosphorylation	PQSQVTLSDIRRAPV CCCEEEHHHHHHCCE		22369663
190	Phosphorylation	RAPVVAASPPPMIRQ HCCEEECCCCCCHHC		21082442
670	Phosphorylation	RRTMPWNSIVTLGNV HHHCCHHHEEHHCHH		19779198
673	Phosphorylation	MPWNSIVTLGNVLVC CCHHHEEHHCHHHHH		19779198
994	Phosphorylation	LRGSKDDTVVEAATR HCCCCCCHHHHHHHH		28889911
1005	Phosphorylation	AATRSVITIRQLYDE HHHHCEEEHHHHHCC		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESL1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESL1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESL1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIN4_YEAST	PIN4	physical	10688190
MTQ2_YEAST	MTQ2	physical	10688190
YPS3_YEAST	YPS3	physical	10688190
PACC_YEAST	RIM101	genetic	20959818
POG1_YEAST	POG1	genetic	20959818
GCR2_YEAST	GCR2	genetic	20959818
HSP71_YEAST	SSA1	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
FUS3_YEAST	FUS3	genetic	23893744
SNX4_YEAST	SNX4	genetic	23893744
PAP2_YEAST	PAP2	genetic	23893744
ESL2_YEAST	ESL2	genetic	23893744
PP2C1_YEAST	PTC1	genetic	27708008
YJ90_YEAST	YJR120W	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
NTR2_YEAST	NTR2	genetic	27708008
SEC12_YEAST	SEC12	genetic	27708008
PP2C3_YEAST	PTC3	genetic	27708008
YSY6_YEAST	YSY6	genetic	27708008
NPL4_YEAST	NPL4	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
PALF_YEAST	RIM8	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
PKR1_YEAST	PKR1	genetic	27708008
TDA1_YEAST	TDA1	genetic	27708008
CPT1_YEAST	CPT1	genetic	27708008
LSM7_YEAST	LSM7	genetic	27708008
DCAM_YEAST	SPE2	genetic	27708008
MSC6_YEAST	MSC6	genetic	27708008
MGR2_YEAST	MGR2	genetic	27708008
THP3_YEAST	THP3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.