PP2C3_YEAST - dbPTM
PP2C3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2C3_YEAST
UniProt AC P34221
Protein Name Protein phosphatase 2C homolog 3
Gene Name PTC3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 468
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Responsible, together with PTC2, for the dephosphorylation of the cyclin-dependent protein kinase CDC28..
Protein Sequence MGQILSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLEQCLIDTFLATDVELLKDEKLKDDHSGCTATVILVSQLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNTKLGPHEQVVTCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNMTLSDISSRIVDVCCSPTTEGSGIGCDNMSISIVALLKENESESQWFERMRSKNYNIQTSFVQRRKSIFDFHDFSDDDNEVFAITTKKLQDRLNRSKDNDDMEIDDLDTELGSSATPSKLSGEDRTGPIDLFSLEALLEAGIQIRQRPSSDSDGNTSYFHGASLSDMLASLSNAAAGETEPNDADDNDDNDGEENGKNENAKKGSKIEEIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MGQILSNPIIDKE
--CCCCCCCCCCCCC		42.0419779198
156PhosphorylationGGNSKAMSFDHKPTL
CCCCCCCCCCCCCCC		32.1727017623
160AcetylationKAMSFDHKPTLLSEK
CCCCCCCCCCCCCCH		41.3524489116
167AcetylationKPTLLSEKSRIVAAD
CCCCCCCHHCEEECC		41.4824489116
324PhosphorylationSFVQRRKSIFDFHDF
HHHHHCCCCCCCCCC		27.0322369663
332PhosphorylationIFDFHDFSDDDNEVF
CCCCCCCCCCCCCEE		46.3022369663
342PhosphorylationDNEVFAITTKKLQDR
CCCEEEEEHHHHHHH		29.1822369663
343PhosphorylationNEVFAITTKKLQDRL
CCEEEEEHHHHHHHH		21.7722369663
370PhosphorylationDLDTELGSSATPSKL
HHCHHCCCCCCHHHC		29.4429136822
371PhosphorylationLDTELGSSATPSKLS
HCHHCCCCCCHHHCC		34.0729136822
373PhosphorylationTELGSSATPSKLSGE
HHCCCCCCHHHCCCC		30.0029136822
375PhosphorylationLGSSATPSKLSGEDR
CCCCCCHHHCCCCCC		41.7029136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2C3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2C3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2C3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ENP1_YEASTENP1physical
11805826
HRR25_YEASTHRR25physical
11805826
PFKA1_YEASTPFK1physical
11805826
RAD50_YEASTRAD50physical
11805826
VPS15_YEASTVPS15physical
11805826
TSR1_YEASTTSR1physical
11805826
PAA1_YEASTPAA1physical
11805826
TDA10_YEASTTDA10physical
11805837
ECM29_YEASTECM29physical
11805837
COPA_YEASTCOP1physical
11805837
TCB1_YEASTTCB1physical
11805837
PAA1_YEASTPAA1physical
11805837
PP2C2_YEASTPTC2genetic
12477803
PTP2_YEASTPTP2genetic
12477803
VPS34_YEASTVPS34physical
16554755
PAA1_YEASTPAA1physical
16429126
RAD50_YEASTRAD50physical
16429126
VPS15_YEASTVPS15physical
16429126
PAA1_YEASTPAA1physical
11283351
PAA1_YEASTPAA1physical
18467557
TDA10_YEASTTDA10physical
18467557
STE50_YEASTSTE50genetic
19269370
SWI5_YEASTSWI5genetic
19269370
MNN10_YEASTMNN10genetic
19269370
FEN1_YEASTRAD27genetic
19269370
PFD5_YEASTGIM5genetic
19269370
IPYR2_YEASTPPA2genetic
19269370
ATPG_YEASTATP3physical
20489023
LCF4_YEASTFAA4physical
20489023
PAA1_YEASTPAA1physical
20489023
RV161_YEASTRVS161physical
20489023
FUS3_YEASTFUS3genetic
21127252
PDP1_YEASTPTC5genetic
25088474
PP2C7_YEASTPTC7genetic
25088474
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2C3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324 AND SER-332, ANDMASS SPECTROMETRY.

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