PTP2_YEAST - dbPTM
PTP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTP2_YEAST
UniProt AC P29461
Protein Name Tyrosine-protein phosphatase 2
Gene Name PTP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 750
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation..
Protein Sequence MDRIAQQYRNGKRDNNGNRMASSAISEKGHIQVNQTRTPGQMPVYRGETINLSNLPQNQIKPCKDLDDVNIRRNNSNRHSKILLLDLCAGPNTNSFLGNTNAKDITVLSLPLPSTLVKRSNYPFENLLKNYLGSDEKYIEFTKIIKDYDIFIFSDSFSRISSCLKTTFCLIEKFKKFICHFFPSPYLKFFLLEGSLNDSKAPSLGKNKKNCILPKLDLNLNVNLTSRSTLNLRINIPPPNDSNKIFLQSLKKDLIHYSPNSLQKFFQFNMPADLAPNDTILPNWLKFCSVKENEKVILKKLFNNFETLENFEMQRLEKCLKFKKKPLHQKQLSQKQRGPQSTDDSKLYSLTSLQRQYKSSLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIKNALPC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationNNGNRMASSAISEKG
CCCCCCCHHHHHHCC		15.8028889911
23PhosphorylationNGNRMASSAISEKGH
CCCCCCHHHHHHCCC		21.7828889911
26PhosphorylationRMASSAISEKGHIQV
CCCHHHHHHCCCEEE		32.7328889911
257PhosphorylationLKKDLIHYSPNSLQK
HHHHHHCCCCCHHHH		20.8719823750
258PhosphorylationKKDLIHYSPNSLQKF
HHHHHCCCCCHHHHH		11.9325521595
261PhosphorylationLIHYSPNSLQKFFQF
HHCCCCCHHHHHHHC		35.2519823750
349PhosphorylationTDDSKLYSLTSLQRQ
CCHHHHHHHHHHHHH		35.2927214570
395PhosphorylationSSDDTIMSPINDYEL
CCCCCEECCCCCHHH		20.8328889911
430PhosphorylationSRVKLPHSPKPPAVS
CCCCCCCCCCCCCCC		32.4517330950
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOG1_YEASTHOG1physical
9032256
SLT2_YEASTSLT2physical
10523653
HOG1_YEASTHOG1physical
9211927
HOG1_YEASTHOG1physical
10817757
HOG1_YEASTHOG1physical
12477803
SLT2_YEASTSLT2physical
11923319
CDK1_YEASTCDC28physical
10580002
SSK1_YEASTSSK1genetic
12944490
PTP3_YEASTPTP3genetic
10679022
NBP2_YEASTNBP2genetic
14685261
PP2C1_YEASTPTC1genetic
8395005
PTP3_YEASTPTP3genetic
12455951
HOG1_YEASTHOG1genetic
14685261
PTP3_YEASTPTP3genetic
10817757
PTP3_YEASTPTP3genetic
15773992
HOG1_YEASTHOG1physical
18212044
PP2C1_YEASTPTC1genetic
19269370
YPD1_YEASTYPD1genetic
19269370
NBP2_YEASTNBP2genetic
19269370
PTP3_YEASTPTP3genetic
19269370
PP2C2_YEASTPTC2genetic
19269370
UBP3_YEASTUBP3genetic
19269370
2ABA_YEASTCDC55genetic
19269370
MNN11_YEASTMNN11genetic
19269370
LCB4_YEASTLCB4genetic
19269370
NBP2_YEASTNBP2genetic
18931302
PTP3_YEASTPTP3genetic
18931302
MSG5_YEASTMSG5genetic
19680630
HOG1_YEASTHOG1genetic
12455951
ADR1_YEASTADR1physical
20489023
NOP12_YEASTNOP12physical
20489023
HKR1_YEASTHKR1genetic
20932477
MSB2_YEASTMSB2genetic
20932477
HOG1_YEASTHOG1genetic
20932477
PBS2_YEASTPBS2genetic
20932477
STE11_YEASTSTE11genetic
20932477
STE50_YEASTSTE50genetic
20932477
OPY2_YEASTOPY2genetic
20932477
STE20_YEASTSTE20genetic
20932477
PP2C1_YEASTPTC1genetic
21127252
RSC2_YEASTRSC2genetic
21127252
DCC1_YEASTDCC1genetic
21127252
FKH2_YEASTFKH2genetic
21127252
IXR1_YEASTIXR1genetic
21127252
MKK1_YEASTMKK1genetic
10523653
MSG5_YEASTMSG5genetic
23063697
CANB_YEASTCNB1genetic
23063697
SLT2_YEASTSLT2genetic
23063697
PTP3_YEASTPTP3genetic
25356552
FXR2_HUMANFXR2physical
27107014
RPGR1_HUMANRPGRIP1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258 AND SER-430, ANDMASS SPECTROMETRY.

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