MSB2_YEAST - dbPTM
MSB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSB2_YEAST
UniProt AC P32334
Protein Name Signaling mucin MSB2
Gene Name MSB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1306
Subcellular Localization Cell membrane
Single-pass membrane protein . localized to polarized sites on the cell surface.
Protein Description Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11..
Protein Sequence MQFPFACLLSTLVISGSLARASPFDFIFGNGTQQAQSQSESQGQVSFTNEASQDSSTTSLVTAYSQGVHSHQSATIVSATISSLPSTWYDASSTSQTSVSYASQESDYAVNQNSWSASTNQLPSTSTTSYYAPTFSTSADFAASSVNAASDVSTASVPIDTSANSIPFTTTSNIETTTSAPLTSDTPLISTSTMSAADNVFSSANPISASLTTTDSSESFDQTSTAGAIPVQSSADFSSSSEILVQSSADFSSPSSPTTTDISLSAAPLQTSESSSFTTASAALPVSSTDVDGSSASPVVSMSAAGQIASSSSTDNPTMSETFSLTSTEVDGSDVSSTVSALLSAPFLQTSTSNSFSIVSPSVSFVPSQSSSDVASSSTANVVSSSFSDIPPQTSTSGSVVSVAQSASALAFQSSTEVYGASASSTMSSLLSTTSLQSTTLDSSSLASSSASSSDLTDYGVSSTASIPLLSASEQASTSSSFSVVSPSVSFVPSQSSSDVASTSAPSVVSSSFSYTSLQAGGSSMTNPSSSTIVYSSSTGSSEESAASTASATLSGSSSTYMAGNLQSQPPSTSSLLSESQATSTSAVLASSSVSTTSPYTTAGGASTEASSLISSTSAETSQVSYSQSTTALQTSSFASSSTTEGSETSSQGFSTSSVLVQMPSSISSEFSPSQTTTQMNSASSSSQYTISSTGILSQVSDTSVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTSVPSTSSRSSVSQVSDTPVPSTSSRSSVSQTSSSLQPTTTSSQRFTISTHGALSESSSVSQQASEITSSINATASEYHSIQTTAATQSTTLSFTDANSSSASAPLEVATSTPTPSSKASSLLLTPSTSSLSQVATNTNVQTSLTTESTTVLEPSTTNSSSTFSLVTSSDNNWWIPTELITQAPEAASTASSTVGGTQTMTLPHAIAAATQVPEPEGYTLITIGFKKALNYEFVVSEPKSSAQIFGYLPEALNTPFKNVFTNITVLQIVPLQDDSLNYLVSVAEVYFPTAEIEELSNLITNSSSAFYTDGMGTAKSMAAMVDSSIPLTGLLHDSNSNSGGSSDGSSSSNSNSGSSGSGSNSNSGVSSSSGNSYQDAGTLEYSSKSNSNVSTSSKSKKKIIGLVIGVVVGGCLYILFMIFAFKYIIRRRIQSQEIIKNPEISSISSSEFGGEKNYNNEKRMSVQESITQSMRIQNWMDDSYYGHGLTNNDSTPTRHNTSSSIPKISRPIASQNSLGWNEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30N-linked_GlycosylationPFDFIFGNGTQQAQS
CCCEECCCCCHHCHH		39.32-
859N-linked_GlycosylationSEITSSINATASEYH
HHHHHHHHCCHHHCC		32.94-
885N-linked_GlycosylationTLSFTDANSSSASAP
EEEEECCCCCCCCCC		45.28-
945N-linked_GlycosylationVLEPSTTNSSSTFSL
EECCCCCCCCCCEEE		39.73-
1049N-linked_GlycosylationPFKNVFTNITVLQIV
CCCCCCCCCEEEEEE		19.23-
1088N-linked_GlycosylationELSNLITNSSSAFYT
HHHHHHHCCCCCCCC		32.66-
1175N-linked_GlycosylationYSSKSNSNVSTSSKS
ECCCCCCCCCCCCHH		35.69-
1223UbiquitinationIQSQEIIKNPEISSI
HHCCHHHCCCCCCCC		72.6023749301
1228PhosphorylationIIKNPEISSISSSEF
HHCCCCCCCCCCCCC		21.6919795423
1229PhosphorylationIKNPEISSISSSEFG
HCCCCCCCCCCCCCC		31.9519795423
1231PhosphorylationNPEISSISSSEFGGE
CCCCCCCCCCCCCCC		29.7419795423
1232PhosphorylationPEISSISSSEFGGEK
CCCCCCCCCCCCCCC		32.0219795423
1233PhosphorylationEISSISSSEFGGEKN
CCCCCCCCCCCCCCC		30.1019795423
1239UbiquitinationSSEFGGEKNYNNEKR
CCCCCCCCCCCCHHH		68.9223749301
1248PhosphorylationYNNEKRMSVQESITQ
CCCHHHHCHHHHHHH		25.3619779198
1252PhosphorylationKRMSVQESITQSMRI
HHHCHHHHHHHHHHH		17.5319779198
1277PhosphorylationHGLTNNDSTPTRHNT
CCCCCCCCCCCCCCC		38.1119779198
1278PhosphorylationGLTNNDSTPTRHNTS
CCCCCCCCCCCCCCC		31.3819779198
1280PhosphorylationTNNDSTPTRHNTSSS
CCCCCCCCCCCCCCC		44.6523749301
1284PhosphorylationSTPTRHNTSSSIPKI
CCCCCCCCCCCCCCC		24.7028132839
1286PhosphorylationPTRHNTSSSIPKISR
CCCCCCCCCCCCCCC		30.1930377154
1287PhosphorylationTRHNTSSSIPKISRP
CCCCCCCCCCCCCCC		42.5530377154
1297PhosphorylationKISRPIASQNSLGWN
CCCCCCCCCCCCCCC		30.5221440633
1300PhosphorylationRPIASQNSLGWNEV-
CCCCCCCCCCCCCC-		22.1824909858
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSB2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSB2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOT2_YEASTCDC36physical
10688190
MAD2_YEASTMAD2physical
10688190
MAD3_YEASTMAD3physical
10688190
NIP7_YEASTNIP7physical
10688190
NDC80_YEASTNDC80physical
10688190
BNI4_YEASTBNI4physical
11489916
CLA4_YEASTCLA4physical
11489916
SHO1_YEASTSHO1physical
15256499
CDC42_YEASTCDC42physical
15256499
STE20_YEASTSTE20genetic
15256499
STE12_YEASTSTE12genetic
15256499
SHO1_YEASTSHO1physical
18591427
SHO1_YEASTSHO1genetic
17627274
HOG1_YEASTHOG1genetic
20932477
PBS2_YEASTPBS2genetic
20932477
STE11_YEASTSTE11genetic
20932477
STE50_YEASTSTE50genetic
20932477
OPY2_YEASTOPY2genetic
20932477
STE20_YEASTSTE20genetic
20932477
FLO11_YEASTFLO11genetic
22496730
SHO1_YEASTSHO1genetic
15256499
GAS1_YEASTGAS1genetic
23891562
KRE1_YEASTKRE1genetic
23891562
GPI13_YEASTGPI13genetic
23891562
PGA3_YEASTPGA3genetic
23891562
BEM1_YEASTBEM1physical
24570489
SWI5_YEASTSWI5genetic
27708008
ORM2_YEASTORM2genetic
27708008
AIM44_YEASTAIM44genetic
27708008
OPY2_YEASTOPY2physical
26598606
SHO1_YEASTSHO1genetic
25724886
SHO1_YEASTSHO1genetic
26116211
IRE1_YEASTIRE1genetic
25666509
STE11_YEASTSTE11physical
25689021
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSB2_YEAST

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Related Literatures of Post-Translational Modification

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