| UniProt ID | IRE1_YEAST | |
|---|---|---|
| UniProt AC | P32361 | |
| Protein Name | Serine/threonine-protein kinase/endoribonuclease IRE1 | |
| Gene Name | IRE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1115 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. |
|
| Protein Description | Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.. | |
| Protein Sequence | MRLLRRNMLVLTLLVCVFSSIISCSIPLSSRTSRRQIVEDEVASTKKLNFNYGVDKNINSPIPAPRTTEGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISVPYLENRSLNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGNIYYFNAHQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPGSKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIHSYDGASYNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLRTNENILVPHPFNPGDHESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNSLKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFKILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEKDNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 111 | N-linked_Glycosylation | ISVPYLENRSLNELS CCCCHHCCCCCCCCC | 35.92 | - | |
| 213 | N-linked_Glycosylation | LKTNIVVNDSGKIVE CEECEEECCCCCEEC | 27.17 | - | |
| 298 | N-linked_Glycosylation | SYDGASYNVTYSTWQ ECCCCCEEEEEEECH | 19.70 | - | |
| 397 | N-linked_Glycosylation | VYLDQTSNLSWFALS EEEECCCCCEEHHCC | 41.29 | - | |
| 592 | Phosphorylation | KSLNCPSSSENVTKP CCCCCCCCCCCCCCC | 27.15 | 27214570 | |
| 593 | Phosphorylation | SLNCPSSSENVTKPF CCCCCCCCCCCCCCC | 37.21 | 28889911 | |
| 635 | Phosphorylation | ADEDDEKSLDLTTEK CCCCCHHHCCCCHHH | 25.68 | 22369663 | |
| 640 | Phosphorylation | EKSLDLTTEKKKRKR HHHCCCCHHHHHHHC | 53.77 | 30377154 | |
| 837 | Phosphorylation | GLCKKLDSGQSSFRT CHHHCCCCCCCCCCC | 49.52 | 30377154 | |
| 840 | Phosphorylation | KKLDSGQSSFRTNLN HCCCCCCCCCCCCCC | 34.66 | 8670804 | |
| 841 | Phosphorylation | KLDSGQSSFRTNLNN CCCCCCCCCCCCCCC | 15.74 | 8670804 | |
| 850 | Phosphorylation | RTNLNNPSGTSGWRA CCCCCCCCCCCCCCH | 57.75 | 23749301 | |
| 876 | Phosphorylation | CQVETEHSSSRHTVV EEEEECCCCCCEEEE | 24.63 | 23749301 | |
| 884 | Phosphorylation | SSRHTVVSSDSFYDP CCCEEEEECCCCCCH | 24.88 | 28889911 | |
| 887 | Phosphorylation | HTVVSSDSFYDPFTK EEEEECCCCCCHHHH | 27.88 | 27017623 | |
| 889 | Phosphorylation | VVSSDSFYDPFTKRR EEECCCCCCHHHHCC | 27.02 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IRE1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRE1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRE1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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