SQS1_YEAST - dbPTM
SQS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SQS1_YEAST
UniProt AC P53866
Protein Name Protein SQS1
Gene Name SQS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 767
Subcellular Localization Cytoplasm . Nucleus .
Protein Description May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants..
Protein Sequence MAKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPTNSWHNSSIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNRYDSSTDLQAGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENEDDDSQNSPSTDHSLSSNESKVEDGDLFFVDEEAQQSPDLTKIKRVCIEEIARPREVAIEFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSEVDQGFNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLPSPASEELEFGFKEEDFVINTNDIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVVDELGLPEDRLPAYLNFIKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHSDIEEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIETKAKKRKAKEDFIDQENRNSNDMLKKYPYGLHIQNIKDEFESFLSRNNDRLTFPPLDPHGNKTVMKIAKHYNMKSSKIGKANHTSVVVEKIKKTKWSSPNYSLIDQLMRQRPVFMRIDIRRPREEQAAFERTKTIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGLGIQGNKGISEPIFAKIKKNRSGLRHSES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationRKIKKKPTPTNSWHN
CCCCCCCCCCCCCCC		52.1823749301
76UbiquitinationGRAFISPKTIEDYYF
CCCEECCCCHHHHHC		56.1723749301
77PhosphorylationRAFISPKTIEDYYFG
CCEECCCCHHHHHCC		32.7428889911
103PhosphorylationGLRPGNRYDSSTDLQ
CCCCCCCCCCCCCHH		24.9522369663
105PhosphorylationRPGNRYDSSTDLQAG
CCCCCCCCCCCHHHH		26.6322369663
106PhosphorylationPGNRYDSSTDLQAGR
CCCCCCCCCCHHHHH		24.0422369663
107PhosphorylationGNRYDSSTDLQAGRA
CCCCCCCCCHHHHHH		44.6822369663
167PhosphorylationFEEPGKMTSDVEYIN
CCCCCCCCCCCEECC		25.8421551504
168PhosphorylationEEPGKMTSDVEYINN
CCCCCCCCCCEECCC		35.8421551504
178PhosphorylationEYINNEDSENEDDDS
EECCCCCCCCCCCCC		35.8221551504
191PhosphorylationDSQNSPSTDHSLSSN
CCCCCCCCCCCCCCC		40.9121551504
217PhosphorylationVDEEAQQSPDLTKIK
ECHHHHHCCCCHHHH		14.3322369663
221PhosphorylationAQQSPDLTKIKRVCI
HHHCCCCHHHHHHHH		37.8022369663
253PhosphorylationTIGKVELSVSEGNES
EEEEEEEEECCCCCC		15.3027017623
255PhosphorylationGKVELSVSEGNESKE
EEEEEEECCCCCCCE		36.0928889911
260PhosphorylationSVSEGNESKEISVDV
EECCCCCCCEEEEEC		39.3224961812
264PhosphorylationGNESKEISVDVPNKG
CCCCCEEEEECCCCC		17.2328889911
292PhosphorylationVLHGMHTSDSDNDEL
HHCCCCCCCCCCCCC		22.0428889911
294PhosphorylationHGMHTSDSDNDELDY
CCCCCCCCCCCCCCE		37.7728889911
334PhosphorylationYVGQRHNSRADNNLL
CCCHHCCCCCCCCCC		23.7917563356
343PhosphorylationADNNLLPSPSPQLTE
CCCCCCCCCCCCCCC		37.6722369663
345PhosphorylationNNLLPSPSPQLTEDI
CCCCCCCCCCCCCCC		29.6122369663
349PhosphorylationPSPSPQLTEDIKCLS
CCCCCCCCCCCEEEE		26.7722369663
353UbiquitinationPQLTEDIKCLSINGT
CCCCCCCEEEEECCE		41.2523749301
356PhosphorylationTEDIKCLSINGTKTF
CCCCEEEEECCEEEE		24.3930377154
372PhosphorylationGNNDNLPSPASEELE
CCCCCCCCCCHHHHH		35.9419795423
375PhosphorylationDNLPSPASEELEFGF
CCCCCCCHHHHHCCC		34.6819795423
521UbiquitinationKHDTERFKTFETKSL
CCCHHHHHEEECCCC		59.5323749301
616PhosphorylationSRNNDRLTFPPLDPH
CCCCCCCCCCCCCCC		34.6827017623
662PhosphorylationIKKTKWSSPNYSLID
HHHCCCCCCCCHHHH		18.9528889911
665PhosphorylationTKWSSPNYSLIDQLM
CCCCCCCCHHHHHHH		14.2928889911
666PhosphorylationKWSSPNYSLIDQLMR
CCCCCCCHHHHHHHH		26.0328889911
735PhosphorylationLEKLGWKSGEGLGIQ
HHHHCCCCCCCCCCC		35.2523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SQS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SQS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SQS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPC72_YEASTSPC72physical
16554755
PRP43_YEASTPRP43physical
16429126
GBLP_YEASTASC1physical
16429126
RS11A_YEASTRPS11Aphysical
16429126
RS11B_YEASTRPS11Aphysical
16429126
SWI6_YEASTSWI6genetic
17314980
FKBP4_YEASTFPR4genetic
17314980
ARX1_YEASTARX1genetic
17314980
BMH1_YEASTBMH1genetic
17314980
HDA1_YEASTHDA1genetic
17314980
MNN10_YEASTMNN10genetic
17314980
SKI2_YEASTSKI2genetic
17314980
REB1_YEASTREB1genetic
17314980
SET2_YEASTSET2genetic
17314980
SIF2_YEASTSIF2genetic
17314980
HOS4_YEASTHOS4genetic
17314980
H2A1_YEASTHTA1genetic
17314980
SNT1_YEASTSNT1genetic
17314980
RPC10_YEASTRPC11genetic
17314980
RAD33_YEASTRAD33genetic
17314980
RPB1_YEASTRPO21genetic
17314980
SET5_YEASTSET5genetic
17314980
SAC3_YEASTSAC3genetic
17314980
RSC6_YEASTRSC6genetic
17314980
LSM1_YEASTLSM1genetic
17314980
SSB1_YEASTSSB1physical
19536198
FKBP4_YEASTFPR4genetic
18408161
BMT5_YEASTBMT5genetic
18408161
SSK22_YEASTSSK22genetic
18408161
PUS7_YEASTPUS7genetic
18408161
ALB1_YEASTALB1genetic
18408161
REXO1_YEASTRNH70genetic
18408161
HOS4_YEASTHOS4genetic
18408161
SP382_YEASTSPP382physical
19581443
PRP43_YEASTPRP43physical
19581443
PRP43_YEASTPRP43physical
19927118
PRP43_YEASTPRP43physical
25808954
MAK5_YEASTMAK5genetic
27708008
SDA1_YEASTSDA1genetic
27708008
IPI1_YEASTIPI1genetic
27708008
MTR4_YEASTMTR4genetic
27708008
SWD2_YEASTSWD2genetic
27708008
RPF2_YEASTRPF2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RRS1_YEASTRRS1genetic
27708008
SWC3_YEASTSWC3genetic
27708008
HAP3_YEASTHAP3genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RIM1_YEASTRIM1genetic
27708008
MAF1_YEASTMAF1genetic
27708008
ARX1_YEASTARX1genetic
27708008
SWR1_YEASTSWR1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
RL29_YEASTRPL29genetic
27708008
CGR1_YEASTCGR1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
REXO1_YEASTRNH70genetic
27708008
LRP1_YEASTLRP1genetic
27708008
AIR1_YEASTAIR1genetic
27708008
BMT5_YEASTBMT5genetic
27708008
FLX1_YEASTFLX1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ARP6_YEASTARP6genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
COA4_YEASTCOA4genetic
27708008
VPS71_YEASTVPS71genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
PUS7_YEASTPUS7genetic
27708008
TMA16_YEASTTMA16genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
MSS18_YEASTMSS18genetic
27708008
SKI3_YEASTSKI3genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SQS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-106; SER-217;SER-255; SER-334; SER-343; SER-345 AND SER-372, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-334 ANDSER-343, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343 AND SER-345, ANDMASS SPECTROMETRY.

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