SET5_YEAST - dbPTM
SET5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SET5_YEAST
UniProt AC P38890
Protein Name Putative protein lysine methyltransferase SET5
Gene Name SET5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 526
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV..
Protein Sequence MTLTIKIGTLNDSDQSAVHNGTENGSDFRKITPTEEEICDDVVLLWKEEPGTEDATIQHLYDRITERNQSWKLSASRFRKILNEHHLYDTDLETVSLYKDKIHFPKALDSDAKVEVKFIDDEHGRGLFAKRDFSKGQIILKENKPIVYIPPLDKLFLISNGKACARCGKALYDLTQHKIMVHYLDCEVCKAIWCSEKCKKAHASLHELLYHSWRSNRIDILHAGNWKRFVNYCEKYCFTAAFSVGLIYGSMLLDTTGEVKEQWQKLASISQRERIKLRDASGIGSTFSLLNGTTVHTEEESDNGTKKGVEKNIDDETVWEKCYELFCGAFPKASEEIDFEKFLTMIGTFNINQYNGQVYHWISFINHDCEPNAYIEQVEEHEELRLHARKPIKKGEQIRITYVNPLHGVRLRRRELRVNWGFLCQCDRCQNELSTFERVPNLEKKNADANLGVEKIDSNDSSEDGSKKSTGNRKSSMREAQPDLKEILKNGKEFELDIPETVDTQGNVRKTSVRFDSNVSVAVDER
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationKIGTLNDSDQSAVHN
EEEECCCCCCCHHHC		36.1521440633
16PhosphorylationTLNDSDQSAVHNGTE
ECCCCCCCHHHCCCC		36.9321440633
22PhosphorylationQSAVHNGTENGSDFR
CCHHHCCCCCCCCCC		31.4321551504
135AcetylationFAKRDFSKGQIILKE
EEECCCCCCCEEEEC		55.6224489116
227AcetylationILHAGNWKRFVNYCE
EEECCCHHHHHHHHH		39.7024489116
311AcetylationGTKKGVEKNIDDETV
CCCCCCCCCCCCHHH		57.7224489116
458PhosphorylationLGVEKIDSNDSSEDG
CCCEECCCCCCCCCC		46.1119823750
461PhosphorylationEKIDSNDSSEDGSKK
EECCCCCCCCCCCCC		39.6221440633
462PhosphorylationKIDSNDSSEDGSKKS
ECCCCCCCCCCCCCC		42.4419823750
466PhosphorylationNDSSEDGSKKSTGNR
CCCCCCCCCCCCCCC		49.5923749301
469PhosphorylationSEDGSKKSTGNRKSS
CCCCCCCCCCCCCHH		45.3319823750
470PhosphorylationEDGSKKSTGNRKSSM
CCCCCCCCCCCCHHH		47.5621440633
475PhosphorylationKSTGNRKSSMREAQP
CCCCCCCHHHHHHCC		26.5717287358
476PhosphorylationSTGNRKSSMREAQPD
CCCCCCHHHHHHCCC		25.5417287358
517PhosphorylationKTSVRFDSNVSVAVD
EEEEEECCCEEEEEC		36.1025752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SET5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SET5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SET5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AIM4_YEASTAIM4genetic
17314980
SLX8_YEASTSLX8genetic
17314980
INO80_YEASTINO80genetic
17314980
FUS3_YEASTFUS3genetic
17314980
COM1_YEASTSAE2genetic
17314980
SLX5_YEASTSLX5genetic
17314980
UBP9_YEASTUBP9genetic
17314980
MED31_YEASTSOH1genetic
17314980
RSC6_YEASTRSC6genetic
17314980
SRB8_YEASTSRB8genetic
17314980
H4_YEASTHHF1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
PHO23_YEASTPHO23genetic
19547744
SWA2_YEASTSWA2genetic
20526336
SLM2_YEASTSLM2genetic
20526336
YOL19_YEASTYOL019Wgenetic
20526336
DS1P2_YEASTYSR3genetic
20526336
H4_YEASTHHF1physical
22343720
SET1_YEASTSET1genetic
22343720
YNG2_YEASTYNG2genetic
22343720
H4_YEASTHHF1physical
22688645
VRP1_YEASTVRP1genetic
27708008
GNP1_YEASTGNP1genetic
27708008
IES1_YEASTIES1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
FMS1_YEASTFMS1genetic
27708008
ATG3_YEASTATG3genetic
27708008
PPAL_YEASTLTP1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SET5_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458 AND SER-517, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-476, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory