SRB8_YEAST - dbPTM
SRB8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRB8_YEAST
UniProt AC P25648
Protein Name Mediator of RNA polymerase II transcription subunit 12
Gene Name SRB8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1427
Subcellular Localization Nucleus .
Protein Description Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5..
Protein Sequence MNNGSGRYLLTPPDDLHPYVPSSKPQEQVYPDFKPWEHTAAEDQILANFVAKGFYHTPMVNFESISARSSVHESLVTQSNILSQQFDKIIKIREDHINKIPSNSTTTLHGPGFQLPNRITLTDHRKETWLHELSSSHTSLVKIGKFIPHGLKRRQVIEQCYLKFIPLKRAIWLIKCCYFIEWKSNHKKKRSNAAGADDAISMHLLKDWTDTFVYILEKLIFDMTNHYNDSQQLRTWKRQISYFLKLLGNCYSLRLINKEIFHHWLVEFINKMENFEFLPLSLHILMIFWNDICQIDTNAPVAATITSSQKEPFFLVTKITDMLLHKYYIVSSSKSMINDENYIINDIKKNNKIKLNILKILSSLILKIFQEQSLEVFIFPTSNWEIYKPLLFEIVSNADTNQNSDMKKKLELISYRNESLKNNSSIRNVIMSASNANDFQLTIVTCKQFPKLSCIQLNCIDTQFTKLLDDNPTEFDWPTYVDQNPLTMHKIIQLILWSIHPSRQFDHYESNQLVAKLLLLRINSTDEDLHEFQIEDAIWSLVFQLAKNFSAQKRVVSYMMPSLYRLLNILITYGIIKVPTYIRKLISSGLLYLQDSNDKFVHVQLLINLKISPLMKSQYNMVLRNVMEYDVKFYEIFNFDQLVEITEQIKMRILSNDITNLQLSKTPLSIKIMVAEWYLSHLCSGILSSVNRTVLLKIFKIFCIDLEVFHHFFKWIEFIVYHQLLSDIESLEALMDILLCYQKLFSQFINDHILFTKTFIFIYKKVLKEKDVPAYNVTSFMPFWKFFMKNFPFVLKVDNDLRIELQSVYNDEKLKTEKLKNDKSEVLKVYSMINNSNQAVGQTWNFPEVFQVNIRFLLHNSEIIDTNTSKQFQKARNNVMLLIATNLKEYNKFMSIFLKRKDFTNKNLIQLISLKLLTFEVTQNVLGLEYIIRLLPINLENNDGSYGLFLKYHKEQFIKSNFEKILLTCYELEKKYHGNECEINYYEILLKILITYGSSPKLLATSTKIIMLLLNDSVENSSNILEDILYYSTCPSETDLNDIPLGSGQPDNDTVVTNDDKSDDDDHTVDEIDHVEYYVMMDFANLWVFQAFTCFCIKKIMENNEPAMAMEDLKNFIFQIIEITNSNDLCSQIFDQLKDMQTIEMITQIVEKDFCTSCLQNNNQKIDDNYIVVVIEIITSLSMRFQRETSGMIVISMENYHLLIKIIRQLSELNEGNLSKREIQIDAVLKIFSFHQDSIFQRIIADLSADKPTSPFIDSICKLFDKISFNLRLKLFLYEILSSLKSFAIYSSTIDAPAFHTSGKVELPKKLLNLPPFQVSSFVKETKLHSGDYGEEEDADQEESFSLNLGIGIVEIAHENEQKWLIYDKKDHKYVCTFSMEPYHFISNYNTKYTDDMATGSNDTTAFNDSCVNLSLFDARFERKNPH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
135PhosphorylationTWLHELSSSHTSLVK
HHHHHHCCCCCCHHH		38.4721440633
335PhosphorylationYIVSSSKSMINDENY
EEEECCHHHHCCCCC		27.1727017623
746PhosphorylationLCYQKLFSQFINDHI
HHHHHHHHHHHHHHH		34.3224930733
756PhosphorylationINDHILFTKTFIFIY
HHHHHCHHHHHHHHH		26.2324930733
758PhosphorylationDHILFTKTFIFIYKK
HHHCHHHHHHHHHHH		20.9324930733
830PhosphorylationKSEVLKVYSMINNSN
HHHHHHHHHHHCCCC		7.3129688323
831PhosphorylationSEVLKVYSMINNSNQ
HHHHHHHHHHCCCCC		19.0429688323
836PhosphorylationVYSMINNSNQAVGQT
HHHHHCCCCCCCCCC		26.3229688323
843PhosphorylationSNQAVGQTWNFPEVF
CCCCCCCCCCCCHHH		19.2229688323
1383PhosphorylationCTFSMEPYHFISNYN
EEEEECCEEEHHCCC		8.9628889911
1387PhosphorylationMEPYHFISNYNTKYT
ECCEEEHHCCCCCCC		32.1128889911
1391PhosphorylationHFISNYNTKYTDDMA
EEHHCCCCCCCCCCC		18.3128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRB8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRB8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRB8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSN3_YEASTSSN3genetic
10924455
MED21_YEASTSRB7physical
16554755
SSN2_YEASTSSN2physical
16554755
MED31_YEASTSOH1physical
16554755
SSN3_YEASTSSN3physical
16554755
MED1_YEASTMED1physical
16429126
MED5_YEASTNUT1physical
16429126
MED16_YEASTSIN4physical
16429126
SSN2_YEASTSSN2physical
16429126
HIR1_YEASTHIR1genetic
17314980
HPC2_YEASTHPC2genetic
17314980
RAD16_YEASTRAD16genetic
17314980
CDC10_YEASTCDC10genetic
17314980
UMP1_YEASTUMP1genetic
17314980
RV161_YEASTRVS161genetic
17314980
SWC3_YEASTSWC3genetic
17314980
MED19_YEASTROX3genetic
17314980
SEC66_YEASTSEC66genetic
17314980
SFL1_YEASTSFL1genetic
9755175
PSD1_YEASTPSD1genetic
20505076
MED15_YEASTGAL11genetic
20505076
PDR3_YEASTPDR3physical
20505076
AHC2_YEASTAHC2genetic
19325107
CAPZA_YEASTCAP1genetic
19325107
ECM30_YEASTECM30genetic
19325107
GET1_YEASTGET1genetic
19325107
GLO3_YEASTGLO3genetic
19325107
GTR1_YEASTGTR1genetic
19325107
H2AZ_YEASTHTZ1genetic
19325107
MGA2_YEASTMGA2genetic
19325107
SPC2_YEASTSPC2genetic
19325107
STP22_YEASTSTP22genetic
19325107
UBX2_YEASTUBX2genetic
19325107
UBX4_YEASTUBX4genetic
19325107
VPS28_YEASTVPS28genetic
19325107
BRE5_YEASTBRE5genetic
19325107
HDA1_YEASTHDA1genetic
21288874
HDA2_YEASTHDA2genetic
21288874
RPN10_YEASTRPN10genetic
21288874
COG4_YEASTCOG4genetic
21288874
RNH1_YEASTRNH1genetic
22195970
RAD51_YEASTRAD51genetic
23795288
RAD52_YEASTRAD52genetic
23795288
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRB8_YEAST

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Related Literatures of Post-Translational Modification

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