| UniProt ID | HIR1_YEAST | |
|---|---|---|
| UniProt AC | P32479 | |
| Protein Name | Protein HIR1 | |
| Gene Name | HIR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 840 | |
| Subcellular Localization | Nucleus . Chromosome, centromere . Enriched at centromeres. | |
| Protein Description | Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.. | |
| Protein Sequence | MKVVKFPWLAHREESRKYEIYTVDVSHDGKRLATGGLDGKIRIWSIDSILRCMELESLTPEIPLPQDLQMPLCSMSRHTGSITCVKFSPDGKYLASGSDDRILLIWALDEEQSSQPAFGSEHEREHWTVRKRLVAHDNDIQDICWAPDSSILVTVGLDRSVIVWNGSTFEKLKRFDVHQSLVKGVVFDPANKYFATTSDDRTMKIFRYHKTGDISFTIEHIITEPFKESPLTTYFRRPSWSPDGQHIAVPNATNGPVSSVAIVNRGTWDTNVSLIGHDAPTEVARFNPRLFERNAGVKQKKDDDPENALVGQNDDKVHHFDKNIDSVVATAGQDKSLAVWSTSRPRPILVAFDIANKSITDMSWNPDGSLLFVASLDSSITLFKFENNELGKPIPLEKNMEQLYRYGVDKDSLDFPESINQLLLEDQTKSFKHTKISTSKLGENHPTLATNSASNQKDNNDASVSRSEHINILIPKRKKDAILNKAVTLKSGKKRVAPTLISTSSSSPFSNGIKKPTLDSKRIENNVKSSTKTINSKNTLLNVPEGVEKKISISSFPLPRLGIHSLIMGTKERSAWKISNSELENDDADNAGGKGSDGTSNSIDDIAVLSEEENDFHRMTLNAKLTQEKIWSEEPTTRCLLQSDVIPDTDVVVLEGGSLDDIAVLEIRNGVERSIQFDSEALLDNPTRILGYQGGKRTIETFIPEVIICAIGSKDCKCWCLASANGSIYILSYNGQQRIPKICLGHKVIKMVTSSKYLLVLTERGLFFAWDLLDLKLVLRNVPILPILNGQPIHGNKVRINKVIKCFRLDGSSCDLLLEVGDPKNVYKWTKDLGCWSLYK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | HREESRKYEIYTVDV CCHHHCCEEEEEEEE | 13.37 | 28889911 | |
| 21 | Phosphorylation | ESRKYEIYTVDVSHD HHCCEEEEEEEECCC | 6.70 | 28889911 | |
| 26 | Phosphorylation | EIYTVDVSHDGKRLA EEEEEEECCCCEEEC | 16.05 | 28889911 | |
| 40 | Ubiquitination | ATGGLDGKIRIWSID CCCCCCCCEEEEEHH | 28.60 | 23749301 | |
| 88 | Phosphorylation | SITCVKFSPDGKYLA CEEEEEECCCCCEEC | 19.16 | 29688323 | |
| 93 | Phosphorylation | KFSPDGKYLASGSDD EECCCCCEECCCCCC | 17.03 | 29688323 | |
| 96 | Phosphorylation | PDGKYLASGSDDRIL CCCCEECCCCCCEEE | 35.91 | 29688323 | |
| 98 | Phosphorylation | GKYLASGSDDRILLI CCEECCCCCCEEEEE | 33.57 | 29688323 | |
| 440 | Acetylation | HTKISTSKLGENHPT CCEECHHHCCCCCCC | 61.68 | 24489116 | |
| 565 | Phosphorylation | LPRLGIHSLIMGTKE CCCCCCCEEEECCCC | 20.05 | 27017623 | |
| 570 | Phosphorylation | IHSLIMGTKERSAWK CCEEEECCCCCEEEE | 16.61 | 27017623 | |
| 574 | Phosphorylation | IMGTKERSAWKISNS EECCCCCEEEECCCH | 39.30 | 27017623 | |
| 579 | Phosphorylation | ERSAWKISNSELEND CCEEEECCCHHHCCC | 30.49 | 28889911 | |
| 581 | Phosphorylation | SAWKISNSELENDDA EEEECCCHHHCCCCC | 36.45 | 25752575 | |
| 596 | Phosphorylation | DNAGGKGSDGTSNSI CCCCCCCCCCCCCCH | 36.03 | 29688323 | |
| 599 | Phosphorylation | GGKGSDGTSNSIDDI CCCCCCCCCCCHHHE | 29.71 | 21440633 | |
| 600 | Phosphorylation | GKGSDGTSNSIDDIA CCCCCCCCCCHHHEE | 33.82 | 29688323 | |
| 602 | Phosphorylation | GSDGTSNSIDDIAVL CCCCCCCCHHHEEEE | 27.45 | 28889911 | |
| 610 | Phosphorylation | IDDIAVLSEEENDFH HHHEEEEECCCCCHH | 36.04 | 22369663 | |
| 620 | Phosphorylation | ENDFHRMTLNAKLTQ CCCHHHHHHCCEECH | 19.47 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HIR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HIR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HIR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, AND MASSSPECTROMETRY. | |
