PPCS_YEAST - dbPTM
PPCS_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPCS_YEAST
UniProt AC P40506
Protein Name Phosphopantothenate--cysteine ligase CAB2
Gene Name CAB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 365
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine..
Protein Sequence MPPLPVLNRPQIHTSVTEISHAIDRTIKEELFPVAYTTEEEQYFKTNPKPAYIDELIKDAKEFIDLQYSLKRNKIVLITSGGTTVPLENNTVRFIDNFSAGTRGASSAEQFLANGYSVIFLHREFSLTPYNRSFSHSINTLFLDYIDSEGKIKPEFAENVLKNKKLYDKYMEKEEKLLLLPFTTVNQYLWSLKSIAKLLNNSGCLFYLAAAVSDFFVPYSRLPQHKIQSGDNGKMGANNDTEGTTRTTPDGKLIVNLDPVPKFLRRLVESWATQAMIVSFKLETDESMLLYKCTQALDRYNHQLVIGNLLQTRNKQVIFVSPENRKGDWVRLDEKHHSIEEMIIPEVIARHDKWVAHSKTKLATK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58AcetylationAYIDELIKDAKEFID
HHHHHHHHHHHHHHH		65.3424489116
68PhosphorylationKEFIDLQYSLKRNKI
HHHHHHHHHHHCCCE		24.2226447709
69PhosphorylationEFIDLQYSLKRNKIV
HHHHHHHHHHCCCEE		17.9126447709
194PhosphorylationQYLWSLKSIAKLLNN
HHHHHHHHHHHHHCC		32.8328889911
234UbiquitinationIQSGDNGKMGANNDT
CCCCCCCCCCCCCCC		40.1823749301
241PhosphorylationKMGANNDTEGTTRTT
CCCCCCCCCCCEEEC		38.1422369663
244PhosphorylationANNDTEGTTRTTPDG
CCCCCCCCEEECCCC		13.5822369663
245PhosphorylationNNDTEGTTRTTPDGK
CCCCCCCEEECCCCC		36.5522369663
247PhosphorylationDTEGTTRTTPDGKLI
CCCCCEEECCCCCEE		40.3622369663
248PhosphorylationTEGTTRTTPDGKLIV
CCCCEEECCCCCEEE		18.9823749301
262AcetylationVNLDPVPKFLRRLVE
EECCCHHHHHHHHHH		58.2124489116
358PhosphorylationHDKWVAHSKTKLATK
CCCHHCCCCCCCCCC		32.0828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPCS_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPCS_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPCS_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
URA7_YEASTURA7genetic
20093466
PLPHP_YEASTYBL036Cgenetic
20093466
YCY9_YEASTYCR099Cgenetic
20093466
BRE1_YEASTBRE1genetic
20093466
NHP10_YEASTNHP10genetic
20093466
PAL1_YEASTPAL1genetic
20093466
RV167_YEASTRVS167genetic
20093466
RS17B_YEASTRPS17Bgenetic
20093466
JIP4_YEASTJIP4genetic
20093466
CLG1_YEASTCLG1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
YG1I_YEASTYGR026Wgenetic
20093466
RTS3_YEASTRTS3genetic
20093466
TDA10_YEASTTDA10genetic
20093466
TBP7_YEASTYTA7genetic
20093466
PTH_YEASTPTH1genetic
20093466
YH10_YEASTYHR210Cgenetic
20093466
PIR5_YEASTYJL160Cgenetic
20093466
YJ24_YEASTKCH1genetic
20093466
PLMT_YEASTOPI3genetic
20093466
SHB17_YEASTSHB17genetic
20093466
UIP5_YEASTUIP5genetic
20093466
HS104_YEASTHSP104genetic
20093466
POM33_YEASTPOM33genetic
20093466
COA4_YEASTCOA4genetic
20093466
YL346_YEASTYLR346Cgenetic
20093466
AMPD_YEASTAMD1genetic
20093466
SRC1_YEASTSRC1genetic
20093466
MVP1_YEASTMVP1genetic
20093466
RIM11_YEASTRIM11genetic
20093466
ATG16_YEASTATG16genetic
20093466
EAR1_YEASTEAR1genetic
20093466
YHM2_YEASTYHM2genetic
20093466
COA6_YEASTCOA6genetic
20093466
SWS2_YEASTSWS2genetic
20093466
OST3_YEASTOST3genetic
20093466
SERC_YEASTSER1genetic
20093466
RDL2_YEASTRDL2genetic
20093466
HAP5_YEASTHAP5genetic
20093466
BEM4_YEASTBEM4genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
KTR6_YEASTKTR6genetic
20093466
PMA2_YEASTPMA2genetic
20093466
QCR2_YEASTQCR2genetic
20093466
COAD_YEASTCAB4physical
23789928
CAB3_YEASTCAB3physical
23789928
RIM11_YEASTRIM11genetic
22282571
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPCS_YEAST

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Related Literatures of Post-Translational Modification

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