JIP4_YEAST - dbPTM
JIP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JIP4_YEAST
UniProt AC Q03361
Protein Name Uncharacterized protein JIP4
Gene Name JIP4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 876
Subcellular Localization
Protein Description
Protein Sequence MVVRDQDEALRNSYKYVKLYVRQDQLEDTVDILAKQDEDKSNNDDRRSLASILDSSSSVKKKGKGSNEKYLPCVSFNTVPRSRVSSPLDEEKREFPGVQISADYTMEEYYDDESGFTSDNNADYFSGNSYSSRREGSASPGRYSSPPPASKRNIKIGKMFKISENGKIVREDYPTTPTDINDALVISRAYANWRQLWIKKKNQIDHRLEQKRDFFNYPTILFPPNKKKSSEGATPTIKFNPPIEDGFTPLTKSQKRKERVLSEKVGFPNTPRTILCHISGRKHTWVALDWALRTLIQNTDHIVVLANLPRLTKNNFEDNDSMSERKRMLMMMDDSRSVSSARRSRSRSRSRSICTRRALSLGPEESDNKLKHQNFIEWTSGYTQNEIERKLQDLFDYVTLIIPQDRSVKVTVEILIGKTKKTLLEAINIYLPDFFVSSTLRWERTDSLVRWKSNFLTDKLCTNFPIPTFIVPAKRMFDLEIDLQKEFKEPEVTKQKNTSGPKPGFSHSKSADASIPTISNIKRKQDNDYSIDSLCYAPEANGANNSSREEASDDELNAFKDDENDVMSVKSLTSNISVKEKLCTMARKRRKSMAQQLNDADHDSSIPPGQRHLKKLNIILESSLKFSLEIDSITDSIENGDVDEKRAHSMESGFEELKRVITGGAPPRHVATPQRSMLDVLDNPSSSRSKSKSRSSSKSRIRDKSKPSSPTATDINSSASASRSRSPQIKFASSVKNVDGNAALGAIKSRHSLDSPGDQQQQHHHHHHRDTDQLSVPGLPHLAPSKSYSVSSGNKDSSLRKVSSSSSLRKVKSNDSNSGKRIKKPVVTSAHLKPSSGGGGLFSFFKSKSRSPSSFRKEDESKNTPKRGGLFGFGRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationQDEALRNSYKYVKLY
HHHHHHHHHHEEEEE		19.3021440633
41PhosphorylationAKQDEDKSNNDDRRS
HHCCCCCCCCCCHHH		53.8619823750
48PhosphorylationSNNDDRRSLASILDS
CCCCCHHHHHHHHHC		29.2222369663
51PhosphorylationDDRRSLASILDSSSS
CCHHHHHHHHHCCCC		29.0422369663
55PhosphorylationSLASILDSSSSVKKK
HHHHHHHCCCCHHHC		28.7722369663
56PhosphorylationLASILDSSSSVKKKG
HHHHHHCCCCHHHCC		26.7121440633
57PhosphorylationASILDSSSSVKKKGK
HHHHHCCCCHHHCCC		43.0022369663
58PhosphorylationSILDSSSSVKKKGKG
HHHHCCCCHHHCCCC		39.6522369663
82PhosphorylationSFNTVPRSRVSSPLD
ECCCCCHHHCCCCCC		30.8521551504
85PhosphorylationTVPRSRVSSPLDEEK
CCCHHHCCCCCCHHH		25.7321551504
86PhosphorylationVPRSRVSSPLDEEKR
CCHHHCCCCCCHHHC		26.9925752575
137PhosphorylationYSSRREGSASPGRYS
CCCCCCCCCCCCCCC		22.3327214570
139PhosphorylationSRREGSASPGRYSSP
CCCCCCCCCCCCCCC		29.5927214570
143PhosphorylationGSASPGRYSSPPPAS
CCCCCCCCCCCCCHH		21.2928889911
144PhosphorylationSASPGRYSSPPPASK
CCCCCCCCCCCCHHH		34.7021126336
145PhosphorylationASPGRYSSPPPASKR
CCCCCCCCCCCHHHC		32.2723749301
173PhosphorylationGKIVREDYPTTPTDI
CEEEECCCCCCCCCH		9.5722369663
175PhosphorylationIVREDYPTTPTDIND
EEECCCCCCCCCHHH		38.9022369663
176PhosphorylationVREDYPTTPTDINDA
EECCCCCCCCCHHHH		21.4922369663
178PhosphorylationEDYPTTPTDINDALV
CCCCCCCCCHHHHHH		47.6322369663
284PhosphorylationHISGRKHTWVALDWA
EECCCCCHHHHHHHH		25.3527017623
299PhosphorylationLRTLIQNTDHIVVLA
HHHHHHCCCEEEEEE		16.7528889911
321PhosphorylationNNFEDNDSMSERKRM
CCCCCCCCHHHHHHH		30.3828889911
323PhosphorylationFEDNDSMSERKRMLM
CCCCCCHHHHHHHHH		37.9024961812
352PhosphorylationRSRSRSRSICTRRAL
HHHHHHHHHHHHHHH		24.2225704821
360PhosphorylationICTRRALSLGPEESD
HHHHHHHHCCCCCCC		30.2322369663
366PhosphorylationLSLGPEESDNKLKHQ
HHCCCCCCCCCCCCC		44.8322890988
422PhosphorylationLIGKTKKTLLEAINI
EECCCHHHHHHHHHH		37.8219779198
430PhosphorylationLLEAINIYLPDFFVS
HHHHHHHHCCHHHHC		14.0119779198
437PhosphorylationYLPDFFVSSTLRWER
HCCHHHHCCCCCEEC		16.6729688323
438PhosphorylationLPDFFVSSTLRWERT
CCHHHHCCCCCEECC		26.5929688323
439PhosphorylationPDFFVSSTLRWERTD
CHHHHCCCCCEECCC		16.9129688323
510PhosphorylationPGFSHSKSADASIPT
CCCCCCCCCCCCCCC		34.1022369663
514PhosphorylationHSKSADASIPTISNI
CCCCCCCCCCCHHHC		29.6428889911
530PhosphorylationRKQDNDYSIDSLCYA
CCCCCCCCCCCEEEC		23.8427017623
533PhosphorylationDNDYSIDSLCYAPEA
CCCCCCCCEEECCCC		20.7628889911
536PhosphorylationYSIDSLCYAPEANGA
CCCCCEEECCCCCCC		30.4027017623
546PhosphorylationEANGANNSSREEASD
CCCCCCCCCCCCCCH		30.4927017623
552PhosphorylationNSSREEASDDELNAF
CCCCCCCCHHHHHHH		49.2017563356
568PhosphorylationDDENDVMSVKSLTSN
CCCCCCCCHHHHHCC		26.6628889911
571PhosphorylationNDVMSVKSLTSNISV
CCCCCHHHHHCCCCH		34.4222369663
573PhosphorylationVMSVKSLTSNISVKE
CCCHHHHHCCCCHHH		27.1522369663
574PhosphorylationMSVKSLTSNISVKEK
CCHHHHHCCCCHHHH		37.1422369663
577PhosphorylationKSLTSNISVKEKLCT
HHHHCCCCHHHHHHH		31.2422369663
592PhosphorylationMARKRRKSMAQQLND
HHHHHHHHHHHHHHH		19.9625752575
649PhosphorylationVDEKRAHSMESGFEE
CCHHHHHHHHHHHHH		24.2228889911
662PhosphorylationEELKRVITGGAPPRH
HHHHHHHHCCCCCCC		27.0625752575
672PhosphorylationAPPRHVATPQRSMLD
CCCCCCCCCCCHHHH		20.9027214570
676PhosphorylationHVATPQRSMLDVLDN
CCCCCCCHHHHHHCC		20.6024961812
686PhosphorylationDVLDNPSSSRSKSKS
HHHCCCCCCCCCCCC		30.9024930733
705PhosphorylationKSRIRDKSKPSSPTA
HHHHCCCCCCCCCCC		54.8324930733
708PhosphorylationIRDKSKPSSPTATDI
HCCCCCCCCCCCCCC		53.3222369663
709PhosphorylationRDKSKPSSPTATDIN
CCCCCCCCCCCCCCC		34.4922369663
711PhosphorylationKSKPSSPTATDINSS
CCCCCCCCCCCCCCC		44.1022369663
713PhosphorylationKPSSPTATDINSSAS
CCCCCCCCCCCCCCC		39.6322369663
717PhosphorylationPTATDINSSASASRS
CCCCCCCCCCCCCCC		27.8422369663
718PhosphorylationTATDINSSASASRSR
CCCCCCCCCCCCCCC		23.0422369663
720PhosphorylationTDINSSASASRSRSP
CCCCCCCCCCCCCCC		28.8221440633
722PhosphorylationINSSASASRSRSPQI
CCCCCCCCCCCCCCC		28.4421440633
726PhosphorylationASASRSRSPQIKFAS
CCCCCCCCCCCEECC		23.5428889911
771PhosphorylationHHHHHRDTDQLSVPG
CCCCCCCCCCCCCCC		26.1219779198
775PhosphorylationHRDTDQLSVPGLPHL
CCCCCCCCCCCCCCC		22.1929136822
785PhosphorylationGLPHLAPSKSYSVSS
CCCCCCCCCCEECCC		28.7319779198
787PhosphorylationPHLAPSKSYSVSSGN
CCCCCCCCEECCCCC		27.2927717283
788PhosphorylationHLAPSKSYSVSSGNK
CCCCCCCEECCCCCC		19.4827717283
789PhosphorylationLAPSKSYSVSSGNKD
CCCCCCEECCCCCCC		23.7119779198
791PhosphorylationPSKSYSVSSGNKDSS
CCCCEECCCCCCCCC		26.9628889911
792PhosphorylationSKSYSVSSGNKDSSL
CCCEECCCCCCCCCC		44.2019779198
801UbiquitinationNKDSSLRKVSSSSSL
CCCCCCEECCCCHHH		52.3323749301
803PhosphorylationDSSLRKVSSSSSLRK
CCCCEECCCCHHHEE		27.7728889911
804PhosphorylationSSLRKVSSSSSLRKV
CCCEECCCCHHHEEH		36.9119684113
805PhosphorylationSLRKVSSSSSLRKVK
CCEECCCCHHHEEHH		19.2123749301
806PhosphorylationLRKVSSSSSLRKVKS
CEECCCCHHHEEHHC		35.0319684113
807PhosphorylationRKVSSSSSLRKVKSN
EECCCCHHHEEHHCC		33.8519684113
851PhosphorylationFFKSKSRSPSSFRKE
HHCCCCCCCHHHCCC		35.9025704821
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JIP4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JIP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JIP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YRA1_YEASTYRA1physical
16554755
JIP4_YEASTJIP4physical
16554755
HCM1_YEASTHCM1genetic
17314980
SWD3_YEASTSWD3genetic
19269370
LCMT1_YEASTPPM1genetic
19269370
PPZ2_YEASTPPZ2genetic
19269370
AAKG_YEASTSNF4genetic
19269370
ADK_YEASTADO1genetic
19269370
RIC1_YEASTRIC1genetic
19269370
SYIC_YEASTILS1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
GLE1_YEASTGLE1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
TAF12_YEASTTAF12genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
MCE1_YEASTCEG1genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SYMC_YEASTMES1genetic
27708008
MED6_YEASTMED6genetic
27708008
RRP3_YEASTRRP3genetic
27708008
RRP4_YEASTRRP4genetic
27708008
SAM35_YEASTSAM35genetic
27708008
IPI1_YEASTIPI1genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
YHS2_YEASTCIA2genetic
27708008
CDC23_YEASTCDC23genetic
27708008
NU192_YEASTNUP192genetic
27708008
TIM16_YEASTPAM16genetic
27708008
ARP3_YEASTARP3genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RPB2_YEASTRPB2genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
PP2B1_YEASTCNA1physical
24930733
PP2B2_YEASTCMP2physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JIP4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; SER-51; SER-55;SER-58; SER-145; THR-176; SER-360 AND SER-552, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.

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