SYIC_YEAST - dbPTM
SYIC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYIC_YEAST
UniProt AC P09436
Protein Name Isoleucine--tRNA ligase, cytoplasmic
Gene Name ILS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1072
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MSESNAHFSFPKEEEKVLSLWDEIDAFHTSLELTKDKPEFSFFDGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKDDVFKYGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTIGFNVIGQEKTQLVAWTTTPWTLPSNLSLCVNADFEYVKIYDETRDRYFILLESLIKTLYKKPKNEKYKIVEKIKGSDLVGLKYEPLFPYFAEQFHETAFRVISDDYVTSDSGTGIVHNAPAFGEEDNAACLKNGVISEDSVLPNAIDDLGRFTKDVPDFEGVYVKDADKLIIKYLTNTGNLLLASQIRHSYPFCWRSDTPLLYRSVPAWFVRVKNIVPQMLDSVMKSHWVPNTIKEKRFANWIANARDWNVSRNRYWGTPIPLWVSDDFEEVVCVGSIKELEELTGVRNITDLHRDVIDKLTIPSKQGKGDLKRIEEVFDCWFESGSMPYASQHYPFENTEKFDERVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKNVIVSGIVLAADGRKMSKSLKNYPDPSIVLNKYGADALRLYLINSPVLKAESLKFKEEGVKEVVSKVLLPWWNSFKFLDGQIALLKKMSNIDFQYDDSVKSDNVMDRWILASMQSLVQFIHEEMGQYKLYTVVPKLLNFIDELTNWYIRFNRRRLKGENGVEDCLKALNSLFDALFTFVRAMAPFTPFLSESIYLRLKEYIPEAVLAKYGKDGRSVHFLSYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVEALKNYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKKLKKDAKKVKDALPSVTSEQVREYLESGKLEVAGIELVKGDLNAIRGLPESAVQAGQETRTDQDVLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKDTIDFEAIVKEHFDMLSKTCRSDIAKYDGSKTDPIGDEEQSINDTIFKLKVFKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSESNAHFS
------CCCCCCCCC		62.1222369663
4Phosphorylation----MSESNAHFSFP
----CCCCCCCCCCC		48.9122369663
9PhosphorylationSESNAHFSFPKEEEK
CCCCCCCCCCHHHHH		30.6722369663
12SuccinylationNAHFSFPKEEEKVLS
CCCCCCCHHHHHHHH		75.6123954790
12AcetylationNAHFSFPKEEEKVLS
CCCCCCCHHHHHHHH		75.6124489116
37AcetylationSLELTKDKPEFSFFD
HHHHCCCCCCCCCCC		48.2624489116
50PhosphorylationFDGPPFATGTPHYGH
CCCCCCCCCCCCCHH		41.8020377248
52PhosphorylationGPPFATGTPHYGHIL
CCCCCCCCCCCHHHH		11.5321440633
97AcetylationPIEHIIDKKLGITGK
CHHHHCCCCCCCCCC		39.2224489116
97UbiquitinationPIEHIIDKKLGITGK
CHHHHCCCCCCCCCC		39.2217644757
98UbiquitinationIEHIIDKKLGITGKD
HHHHCCCCCCCCCCC		48.4717644757
104SuccinylationKKLGITGKDDVFKYG
CCCCCCCCCHHHHHH		41.9523954790
104UbiquitinationKKLGITGKDDVFKYG
CCCCCCCCCHHHHHH		41.9517644757
104AcetylationKKLGITGKDDVFKYG
CCCCCCCCCHHHHHH		41.9524489116
109UbiquitinationTGKDDVFKYGLENYN
CCCCHHHHHHHHHCC		37.9517644757
109AcetylationTGKDDVFKYGLENYN
CCCCHHHHHHHHHCC		37.9524489116
121PhosphorylationNYNNECRSIVMTYAS
HCCCHHHHHHEHHHH		31.0621440633
133PhosphorylationYASDWRKTIGRLGRW
HHHHHHHHHHHHCCC		21.7921551504
147PhosphorylationWIDFDNDYKTMYPSF
CEECCCCCHHHCHHH		18.0221551504
148UbiquitinationIDFDNDYKTMYPSFM
EECCCCCHHHCHHHH		29.6715699485
176UbiquitinationGQVYRGFKVMPYSTG
CCEECCEEEECCCCC		40.2123749301
186PhosphorylationPYSTGLTTPLSNFEA
CCCCCCCCCCCCHHH		27.5528889911
189PhosphorylationTGLTTPLSNFEAQQN
CCCCCCCCCHHHHHH		40.4519779198
263UbiquitinationILLESLIKTLYKKPK
HHHHHHHHHHHHCCC		37.4617644757
274PhosphorylationKKPKNEKYKIVEKIK
HCCCCCCCEEEEECC		10.3628889911
279UbiquitinationEKYKIVEKIKGSDLV
CCCEEEEECCCCCCC		38.5317644757
281UbiquitinationYKIVEKIKGSDLVGL
CEEEEECCCCCCCCC		64.5317644757
289UbiquitinationGSDLVGLKYEPLFPY
CCCCCCCCEEECHHH		41.4617644757
339UbiquitinationEDNAACLKNGVISED
CCCHHHHHCCCCCCC		52.0917644757
361AcetylationDDLGRFTKDVPDFEG
HHHCCCCCCCCCCCC		54.7524489116
361UbiquitinationDDLGRFTKDVPDFEG
HHHCCCCCCCCCCCC		54.7515699485
372UbiquitinationDFEGVYVKDADKLII
CCCCEECCCHHHHHH		29.5215699485
372AcetylationDFEGVYVKDADKLII
CCCCEECCCHHHHHH		29.5224489116
376AcetylationVYVKDADKLIIKYLT
EECCCHHHHHHHHHH		43.2224489116
376UbiquitinationVYVKDADKLIIKYLT
EECCCHHHHHHHHHH		43.2215699485
380UbiquitinationDADKLIIKYLTNTGN
CHHHHHHHHHHHCCC		27.4922106047
404PhosphorylationSYPFCWRSDTPLLYR
CCCCCCCCCCCCEEC		22.7228889911
406PhosphorylationPFCWRSDTPLLYRSV
CCCCCCCCCCEECCC		19.6522369663
412PhosphorylationDTPLLYRSVPAWFVR
CCCCEECCCCHHHHH		20.9228889911
421UbiquitinationPAWFVRVKNIVPQML
CHHHHHHHHHHHHHH		30.3223749301
486UbiquitinationVVCVGSIKELEELTG
EEEEEEHHHHHHHHC		58.9222106047
507AcetylationLHRDVIDKLTIPSKQ
HCHHHHHHHCCCCCC		36.0824489116
507UbiquitinationLHRDVIDKLTIPSKQ
HCHHHHHHHCCCCCC		36.0823749301
604PhosphorylationAADGRKMSKSLKNYP
EECCCCCCHHHCCCC		23.3324961812
608SuccinylationRKMSKSLKNYPDPSI
CCCCHHHCCCCCHHH		62.6223954790
614PhosphorylationLKNYPDPSIVLNKYG
HCCCCCHHHHHHCCC		32.4828889911
619AcetylationDPSIVLNKYGADALR
CHHHHHHCCCHHHHH		40.6824489116
619UbiquitinationDPSIVLNKYGADALR
CHHHHHHCCCHHHHH		40.6824961812
632PhosphorylationLRLYLINSPVLKAES
HHHHHHCCCCCCHHH		14.9128152593
636AcetylationLINSPVLKAESLKFK
HHCCCCCCHHHHCCC		50.7924489116
636UbiquitinationLINSPVLKAESLKFK
HHCCCCCCHHHHCCC		50.7924961812
641UbiquitinationVLKAESLKFKEEGVK
CCCHHHHCCCHHHHH		64.7617644757
6482-HydroxyisobutyrylationKFKEEGVKEVVSKVL
CCCHHHHHHHHHHHH		56.50-
673SuccinylationDGQIALLKKMSNIDF
HHHHHHHHHHHCCCC		47.4823954790
673AcetylationDGQIALLKKMSNIDF
HHHHHHHHHHHCCCC		47.4824489116
674UbiquitinationGQIALLKKMSNIDFQ
HHHHHHHHHHCCCCC		47.7524961812
743UbiquitinationRFNRRRLKGENGVED
HHHHHHHCCCCCHHH		63.4723749301
7852-HydroxyisobutyrylationESIYLRLKEYIPEAV
HHHHHHHHHHCCHHH		41.88-
785AcetylationESIYLRLKEYIPEAV
HHHHHHHHHHCCHHH		41.8824489116
785SuccinylationESIYLRLKEYIPEAV
HHHHHHHHHHCCHHH		41.8823954790
795AcetylationIPEAVLAKYGKDGRS
CCHHHHHHHCCCCCE		50.8324489116
802PhosphorylationKYGKDGRSVHFLSYP
HHCCCCCEEEEEECC		26.0219823750
807PhosphorylationGRSVHFLSYPVVKKE
CCEEEEEECCEECHH		26.8419823750
808PhosphorylationRSVHFLSYPVVKKEY
CEEEEEECCEECHHH		11.3719823750
812AcetylationFLSYPVVKKEYFDEA
EEECCEECHHHHHHH		39.8724489116
812UbiquitinationFLSYPVVKKEYFDEA
EEECCEECHHHHHHH		39.8717644757
8122-HydroxyisobutyrylationFLSYPVVKKEYFDEA
EEECCEECHHHHHHH		39.87-
813UbiquitinationLSYPVVKKEYFDEAI
EECCEECHHHHHHHH		46.1417644757
829PhosphorylationTAVSRMQSVIDLGRN
HHHHHHHHHHHHCCC		16.2322369663
8412-HydroxyisobutyrylationGRNIREKKTISLKTP
CCCHHHCCCEECCCC		46.46-
846AcetylationEKKTISLKTPLKTLV
HCCCEECCCCCEEEE		41.1124489116
8462-HydroxyisobutyrylationEKKTISLKTPLKTLV
HCCCEECCCCCEEEE		41.11-
847PhosphorylationKKTISLKTPLKTLVI
CCCEECCCCCEEEEE		38.8621440633
860PhosphorylationVILHSDESYLKDVEA
EEECCCHHHHHCHHH		40.5330377154
889AcetylationVITSDEAKYGVEYKA
EEECCHHHHCCEEEE		40.2524489116
889UbiquitinationVITSDEAKYGVEYKA
EEECCHHHHCCEEEE		40.2523749301
905SuccinylationADWPVLGKKLKKDAK
CCCHHCCHHHHHHHH		51.2623954790
920PhosphorylationKVKDALPSVTSEQVR
HHHHHCCCCCHHHHH		38.5928889911
934AcetylationREYLESGKLEVAGIE
HHHHHCCCCEEEEEE		51.2424489116
944UbiquitinationVAGIELVKGDLNAIR
EEEEEEEECCHHHHC		60.3724961812
1044AcetylationTCRSDIAKYDGSKTD
HHHHHHHHCCCCCCC		44.1824489116
1044UbiquitinationTCRSDIAKYDGSKTD
HHHHHHHHCCCCCCC		44.1823749301
1049UbiquitinationIAKYDGSKTDPIGDE
HHHCCCCCCCCCCCC		63.5817644757
1049AcetylationIAKYDGSKTDPIGDE
HHHCCCCCCCCCCCC		63.5824489116
1059PhosphorylationPIGDEEQSINDTIFK
CCCCCHHCHHHHEEE		27.0022369663
1066AcetylationSINDTIFKLKVFKL-
CHHHHEEEEEEEEC-		43.4724489116
1066UbiquitinationSINDTIFKLKVFKL-
CHHHHEEEEEEEEC-		43.4717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYIC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYIC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYIC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPS2_YEASTTPS2genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
GPP2_YEASTGPP2genetic
21623372
LTHAD_YEASTSRY1genetic
21623372
ELO3_YEASTELO3genetic
21623372
ODPB_YEASTPDB1genetic
21623372
KAD2_YEASTADK1genetic
21623372
SWC5_YEASTSWC5genetic
27708008
YNE6_YEASTYNL046Wgenetic
27708008
ZPR1_YEASTZPR1genetic
27708008
TAD2_YEASTTAD2genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
TAD3_YEASTTAD3genetic
27708008
EF1A_YEASTTEF2genetic
27708008
TPS1_YEASTTPS1genetic
27708008
ELO2_YEASTELO2genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SWF1_YEASTSWF1genetic
27708008
UBP3_YEASTUBP3genetic
27708008
XRN1_YEASTXRN1genetic
27708008
CBP4_YEASTCBP4genetic
27708008
REXO1_YEASTRNH70genetic
27708008
FSH1_YEASTFSH1genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
FMC1_YEASTFMC1genetic
27708008
SNX4_YEASTSNX4genetic
27708008
PEP8_YEASTPEP8genetic
27708008
MPCP_YEASTMIR1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
MDM35_YEASTMDM35genetic
27708008
XPOT_YEASTLOS1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
AIM29_YEASTAIM29genetic
27708008
SDHB_YEASTSDH2genetic
27708008
YL050_YEASTYLR050Cgenetic
27708008
LAM6_YEASTYLR072Wgenetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
NKP2_YEASTNKP2genetic
27708008
F16P_YEASTFBP1genetic
27708008
ATP10_YEASTATP10genetic
27708008
SRC1_YEASTSRC1genetic
27708008
MUB1_YEASTMUB1genetic
27708008
NGL2_YEASTNGL2genetic
27708008
MKT1_YEASTMKT1genetic
27708008
YNJ5_YEASTYNL095Cgenetic
27708008
BRE5_YEASTBRE5genetic
27708008
PHO80_YEASTPHO80genetic
27708008
MDM38_YEASTMDM38genetic
27708008
SDHF2_YEASTSDH5genetic
27708008
MRS2_YEASTMRS2genetic
27708008
PMA2_YEASTPMA2genetic
27708008
WDR6_YEASTRTT10genetic
27708008
YP225_YEASTYPL225Wgenetic
27708008
PMP1_YEASTPMP1physical
26404137
SSB1_YEASTSSB1physical
24488121
SSB2_YEASTSSB2physical
24488121
SSZ1_YEASTSSZ1physical
24488121
ZUO1_YEASTZUO1physical
24488121
ARC1_YEASTARC1physical
24488121
TRPE_YEASTTRP2physical
24488121
HOC1_YEASTHOC1physical
24488121
SYV_YEASTVAS1physical
24488121
SYTC_YEASTTHS1physical
24488121
EMP47_YEASTEMP47physical
24488121
EF3A_YEASTYEF3physical
24488121
RS19A_YEASTRPS19Aphysical
24488121
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYIC_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186; THR-406; SER-829AND SER-1059, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1059, AND MASSSPECTROMETRY.

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