F16P_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F16P_YEAST
• UniProt AC: P09201
• Protein Name: Fructose-1,6-bisphosphatase
• Gene Name: FBP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 348
• Protein Sequence: MPTLVNGPRRDSTEGFDTDIITLPRFIIEHQKQFKNATGDFTLVLNALQFAFKFVSHTIRRAELVNLVGLAGASNFTGDQQKKLDVLGDEIFINAMRASGIIKVLVSEEQEDLIVFPTNTGSYAVCCDPIDGSSNLDAGVSVGTIASIFRLLPDSSGTINDVLRCGKEMVAACYAMYGSSTHLVLTLGDGVDGFTLDTNLGEFILTHPNLRIPPQKAIYSINEGNTLYWNETIRTFIEKVKQPQADNNNKPFSARYVGSMVADVHRTFLYGGLFAYPCDKKSPNGKLRLLYEAFPMAFLMEQAGGKAVNDRGERILDLVPSHIHDKSSIWLGSSGEIDKFLDHIGKSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VNGPRRDSTEGFDTD CCCCCCCCCCCCCCC	26.92	3038868
13	Phosphorylation	NGPRRDSTEGFDTDI CCCCCCCCCCCCCCC	44.40	29136822
18	Phosphorylation	DSTEGFDTDIITLPR CCCCCCCCCCEECCH	27.17	29136822

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
12	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	GRR1	P24814	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RMD5	Q12508	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F16P_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F16P_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDHC_YEAST	MDH2	physical	12730240
REG1_YEAST	REG1	physical	14684743
CYSD_YEAST	MET17	physical	14684743
YN94_YEAST	YNR065C	physical	14684743
UBX1_YEAST	SHP1	physical	16554755
CDC48_YEAST	CDC48	physical	16554755
F16P_YEAST	FBP1	physical	11283351
F16P_YEAST	FBP1	physical	18719252
GSM1_YEAST	GSM1	physical	18719252
CAK1_YEAST	CAK1	genetic	19269370
PFKA1_YEAST	PFK1	genetic	19269370
VID30_YEAST	VID30	physical	18508925
KCS1_YEAST	KCS1	physical	20457600
YHP7_YEAST	YHR097C	physical	20457600
HSC82_YEAST	HSC82	physical	20457600
GYP1_YEAST	GYP1	physical	20457600
AKL1_YEAST	AKL1	physical	20457600
PPZ1_YEAST	PPZ1	physical	20457600
ARP5_YEAST	ARP5	physical	20457600
ARP6_YEAST	ARP6	physical	20457600
ARP8_YEAST	ARP8	physical	20457600
MDS3_YEAST	MDS3	physical	20457600
UBC2_YEAST	RAD6	physical	20457600
UBP14_YEAST	UBP14	physical	20457600
AIM32_YEAST	AIM32	physical	20457600
HSV2_YEAST	HSV2	physical	20457600
TCO89_YEAST	TCO89	physical	20457600
TOR1_YEAST	TOR1	physical	20457600
KOG1_YEAST	KOG1	physical	20457600
LST8_YEAST	LST8	physical	20457600
HSP71_YEAST	SSA1	physical	20513352
KCS1_YEAST	KCS1	genetic	21623372
FMS1_YEAST	FMS1	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
6PGD1_YEAST	GND1	genetic	21623372
COX6_YEAST	COX6	genetic	21623372
DCOR_YEAST	SPE1	genetic	21623372
ATPK_YEAST	ATP17	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
KAD2_YEAST	ADK1	genetic	21623372
GAS4_YEAST	GAS4	genetic	21623372
DCAM_YEAST	SPE2	genetic	21623372
ALDH5_YEAST	ALD5	genetic	21623372
HTD2_YEAST	HTD2	genetic	21623372
SUR2_YEAST	SUR2	genetic	21623372
PHSG_YEAST	GPH1	genetic	21623372
GPT1_YEAST	SCT1	genetic	21623372
FABG_YEAST	OAR1	genetic	21623372
PDE2_YEAST	PDE2	genetic	21623372
TOR1_YEAST	TOR1	physical	20617129
TOR2_YEAST	TOR2	physical	20617129
KOG1_YEAST	KOG1	physical	20617129
LST8_YEAST	LST8	physical	20617129
GID4_YEAST	VID24	physical	28126757
F16P1_HUMAN	FBP1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.