MDHC_YEAST - dbPTM
MDHC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MDHC_YEAST
UniProt AC P22133
Protein Name Malate dehydrogenase, cytoplasmic
Gene Name MDH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 377
Subcellular Localization Cytoplasm.
Protein Description The isoenzyme MDH2 may function primarily in the glyoxylate cycle..
Protein Sequence MPHSVTPSIEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEFVASRSASS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPHSVTPSIEQ
----CCCCCCCCCCH		23.0922369663
6Phosphorylation--MPHSVTPSIEQDS
--CCCCCCCCCCHHH		17.8422369663
8PhosphorylationMPHSVTPSIEQDSLK
CCCCCCCCCCHHHHH		29.4122369663
13PhosphorylationTPSIEQDSLKIAILG
CCCCCHHHHHHEEHH		31.1222369663
15UbiquitinationSIEQDSLKIAILGAA
CCCHHHHHHEEHHHC		33.7617644757
34UbiquitinationQSLSLLLKAQLQYQL
HHHHHHHHHHHHHHH		33.7717644757
42UbiquitinationAQLQYQLKESNRSVT
HHHHHHHHHCCCCCE		43.5023749301
180UbiquitinationRRIMGVTKLDIVRAS
HHHCCCCHHHHHHHH		41.5823749301
180AcetylationRRIMGVTKLDIVRAS
HHHCCCCHHHHHHHH		41.5824489116
197PhosphorylationLREINIESGLTPRVN
HHHHCCCCCCCCCCC		34.9930377154
200PhosphorylationINIESGLTPRVNSMP
HCCCCCCCCCCCCCC		16.7529734811
239UbiquitinationRLNEDQLKYLIHRVQ
HCCHHHHHHHHHHHC		32.1715699485
239AcetylationRLNEDQLKYLIHRVQ
HCCHHHHHHHHHHHC		32.1724489116
254UbiquitinationYGGDEVVKAKNGKGS
CCCCEEEECCCCCCE		59.8423749301
256UbiquitinationGDEVVKAKNGKGSAT
CCEEEECCCCCCEEE		61.5915699485
259UbiquitinationVVKAKNGKGSATLSM
EEECCCCCCEEEHHH		60.1123749301
272UbiquitinationSMAHAGYKCVVQFVS
HHHCCCHHHHHHHHH		21.4515699485
330UbiquitinationIPLTITTKGVSYVDY
EEEEEECCCCCEECH		48.9815699485
360UbiquitinationPICVSQLKKNIDKGL
HHHHHHHHHHHHHHH		35.8217644757
361UbiquitinationICVSQLKKNIDKGLE
HHHHHHHHHHHHHHH		68.6617644757
365AcetylationQLKKNIDKGLEFVAS
HHHHHHHHHHHHHHH		62.6924489116
365UbiquitinationQLKKNIDKGLEFVAS
HHHHHHHHHHHHHHH		62.6915699485
372PhosphorylationKGLEFVASRSASS--
HHHHHHHHCCCCC--		22.8227214570
374PhosphorylationLEFVASRSASS----
HHHHHHCCCCC----		29.9727017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MDHC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MDHC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MDHC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LCF4_YEASTFAA4physical
11805837
MET18_YEASTMET18physical
11805837
PDI_YEASTPDI1physical
11805837
EXG1_YEASTEXG1physical
11805837
YIK8_YEASTYIL108Wphysical
11805837
RPN5_YEASTRPN5physical
11805837
RFC2_YEASTRFC2physical
11805837
MDHC_YEASTMDH2physical
12730240
MDHP_YEASTMDH3genetic
1447211
GET3_YEASTGET3physical
11283351
GET3_YEASTGET3physical
18719252
GST1_YEASTGTT1physical
18719252
KPYK2_YEASTPYK2physical
18719252
MGA2_YEASTMGA2physical
18719252
TOR1_YEASTTOR1physical
20457600
KOG1_YEASTKOG1physical
20457600
LST8_YEASTLST8physical
20457600
FABG_YEASTOAR1genetic
21623372
DCOR_YEASTSPE1genetic
21623372
PYC2_YEASTPYC2genetic
22851014
ORC2_YEASTORC2genetic
27708008
TAF5_YEASTTAF5genetic
27708008
KRR1_YEASTKRR1genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC53_YEASTCDC53genetic
27708008
NOP14_YEASTNOP14genetic
27708008
RMRP_YEASTSNM1genetic
27708008
ACT_YEASTACT1genetic
27708008
HSF_YEASTHSF1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
XPO1_YEASTCRM1genetic
27708008
HSP77_YEASTSSC1genetic
27708008
FIP1_YEASTFIP1genetic
27708008
SEN1_YEASTSEN1genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
MEX67_YEASTMEX67genetic
27708008
THRC_YEASTTHR4genetic
27708008
MTW1_YEASTMTW1genetic
27708008
KPYK1_YEASTCDC19genetic
27708008
LSM2_YEASTLSM2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
PRP6_YEASTPRP6genetic
27708008
ALG1_YEASTALG1genetic
27708008
POP7_YEASTPOP7genetic
27708008
MED8_YEASTMED8genetic
27708008
PRP5_YEASTPRP5genetic
27708008
PRP9_YEASTPRP9genetic
27708008
PRP11_YEASTPRP11genetic
27708008
LUC7_YEASTLUC7genetic
27708008
SNU23_YEASTSNU23genetic
27708008
CDC48_YEASTCDC48genetic
27708008
RPB1_YEASTRPO21genetic
27708008
RPC10_YEASTRPC11genetic
27708008
SLU7_YEASTSLU7genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
PRP28_YEASTPRP28genetic
27708008
TFC6_YEASTTFC6genetic
27708008
SYF1_YEASTSYF1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
PRP3_YEASTPRP3genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
COPB2_YEASTSEC27genetic
27708008
PRP18_YEASTPRP18genetic
27708008
TFC4_YEASTTFC4genetic
27708008
PRP38_YEASTPRP38genetic
27708008
PRP31_YEASTPRP31genetic
27708008
DAM1_YEASTDAM1genetic
27708008
OKP1_YEASTOKP1genetic
27708008
CWC22_YEASTCWC22genetic
27708008
MED6_YEASTMED6genetic
27708008
DNA2_YEASTDNA2genetic
27708008
BET1_YEASTBET1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
ARP4_YEASTARP4genetic
27708008
KRE9_YEASTKRE9genetic
27708008
PRP21_YEASTPRP21genetic
27708008
CDC11_YEASTCDC11genetic
27708008
MIF2_YEASTMIF2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SN114_YEASTSNU114genetic
27708008
YKT6_YEASTYKT6genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
BBP_YEASTMSL5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
POB3_YEASTPOB3genetic
27708008
TAF8_YEASTTAF8genetic
27708008
VTI1_YEASTVTI1genetic
27708008
CEF1_YEASTCEF1genetic
27708008
RNT1_YEASTRNT1genetic
27708008
FCP1_YEASTFCP1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
SEC12_YEASTSEC12genetic
27708008
RPC1_YEASTRPO31genetic
27708008
RPB2_YEASTRPB2genetic
27708008
MED4_YEASTMED4genetic
27708008
TOA1_YEASTTOA1genetic
27708008
COPZ_YEASTRET3genetic
27708008
NAB3_YEASTNAB3genetic
27708008
HRR25_YEASTHRR25genetic
27708008
IPL1_YEASTIPL1genetic
27708008
CET1_YEASTCET1genetic
27708008
CCL1_YEASTCCL1genetic
27708008
ARP7_YEASTARP7genetic
27708008
SEC8_YEASTSEC8genetic
27708008
DIB1_YEASTDIB1genetic
27708008
TF2B_YEASTSUA7genetic
27708008
SRP54_YEASTSRP54genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PSB5_YEASTPRE2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SEC23_YEASTSEC23genetic
27708008
REI1_YEASTREI1genetic
27708008
SSH1_YEASTSSH1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
PUF6_YEASTPUF6genetic
27708008
ASK10_YEASTASK10genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ERG3_YEASTERG3genetic
27708008
ERG6_YEASTERG6genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MDHC_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, AND MASSSPECTROMETRY.

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