| UniProt ID | KPYK2_YEAST | |
|---|---|---|
| UniProt AC | P52489 | |
| Protein Name | Pyruvate kinase 2 | |
| Gene Name | PYK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 506 | |
| Subcellular Localization | ||
| Protein Description | May be used by cells under conditions in which the level of glycolytic flux is very low.. | |
| Protein Sequence | MPESRLQRLANLKIGTPQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPLAIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRISTVGQEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | LANLKIGTPQQLRRT HHCCCCCCHHHHHHC | 22.77 | 27214570 | |
| 23 | Phosphorylation | TPQQLRRTSIIGTIG CHHHHHHCEEEEEEC | 20.17 | 22890988 | |
| 24 | Phosphorylation | PQQLRRTSIIGTIGP HHHHHHCEEEEEECC | 15.48 | 22369663 | |
| 28 | Phosphorylation | RRTSIIGTIGPKTNS HHCEEEEEECCCCCC | 16.62 | 22890988 | |
| 32 | Ubiquitination | IIGTIGPKTNSCEAI EEEEECCCCCCHHHH | 55.94 | 17644757 | |
| 87 | Phosphorylation | PLAIALDTKGPEIRT CEEEEECCCCCCCCC | 38.46 | 28889911 | |
| 88 | Ubiquitination | LAIALDTKGPEIRTG EEEEECCCCCCCCCC | 72.62 | 24961812 | |
| 199 | Acetylation | PLSAKDMKDLQFGVR CCCHHHHHHCCCHHH | 66.47 | 24489116 | |
| 405 | Phosphorylation | KAIVVLSTTGNTARL CEEEEEECCCHHHHH | 34.26 | 28889911 | |
| 406 | Phosphorylation | AIVVLSTTGNTARLL EEEEEECCCHHHHHH | 25.67 | 28889911 | |
| 409 | Phosphorylation | VLSTTGNTARLLSKY EEECCCHHHHHHHHH | 17.94 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KPYK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KPYK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KPYK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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