| UniProt ID | HSP77_YEAST | |
|---|---|---|
| UniProt AC | P0CS90 | |
| Protein Name | Heat shock protein SSC1, mitochondrial | |
| Gene Name | SSC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 654 | |
| Subcellular Localization | Mitochondrion matrix. Nucleus. Detected also in the nucleus after heat shock. | |
| Protein Description | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion.; Acts as a non-catalytic component of endonuclease SceI (Endo.SceI), which cleaves specifically at multiple sites on mitochondrial DNA and produces double-stranded breaks. SSC1 confers broader sequence specificity, greater stability, and higher activity on the catalytic subunit (By similarity).. | |
| Protein Sequence | MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFSRAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVNPDEAVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNGNNAESGETKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Ubiquitination | ---MLAAKNILNRSS ---CCCHHHCCCHHC | 38.62 | 24961812 | |
| 5 | Acetylation | ---MLAAKNILNRSS ---CCCHHHCCCHHC | 38.62 | 24489116 | |
| 11 | Phosphorylation | AKNILNRSSLSSSFR HHHCCCHHCCCHHHH | 34.26 | 22369663 | |
| 12 | Phosphorylation | KNILNRSSLSSSFRI HHCCCHHCCCHHHHH | 29.09 | 22369663 | |
| 14 | Phosphorylation | ILNRSSLSSSFRIAT CCCHHCCCHHHHHHH | 26.36 | 22369663 | |
| 15 | Phosphorylation | LNRSSLSSSFRIATR CCHHCCCHHHHHHHH | 38.50 | 22369663 | |
| 16 | Phosphorylation | NRSSLSSSFRIATRL CHHCCCHHHHHHHHH | 18.37 | 22369663 | |
| 21 | Phosphorylation | SSSFRIATRLQSTKV CHHHHHHHHHHCCCC | 29.55 | 28889911 | |
| 27 | Ubiquitination | ATRLQSTKVQGSVIG HHHHHCCCCCCEEEE | 37.50 | 22817900 | |
| 31 | Phosphorylation | QSTKVQGSVIGIDLG HCCCCCCEEEEEEEC | 8.09 | 21440633 | |
| 39 | Phosphorylation | VIGIDLGTTNSAVAI EEEEEECCCCCEEHH | 30.05 | 29136822 | |
| 40 | Phosphorylation | IGIDLGTTNSAVAIM EEEEECCCCCEEHHH | 25.94 | 29136822 | |
| 42 | Phosphorylation | IDLGTTNSAVAIMEG EEECCCCCEEHHHCC | 23.25 | 29136822 | |
| 53 | Acetylation | IMEGKVPKIIENAEG HHCCCCCCEEECCCC | 60.34 | 24489116 | |
| 61 | Phosphorylation | IIENAEGSRTTPSVV EEECCCCCCCCCCEE | 20.26 | 22369663 | |
| 63 | Phosphorylation | ENAEGSRTTPSVVAF ECCCCCCCCCCEEEE | 44.76 | 22369663 | |
| 64 | Phosphorylation | NAEGSRTTPSVVAFT CCCCCCCCCCEEEEE | 16.68 | 22369663 | |
| 66 | Phosphorylation | EGSRTTPSVVAFTKE CCCCCCCCEEEEECC | 27.42 | 24961812 | |
| 71 | Phosphorylation | TPSVVAFTKEGERLV CCCEEEEECCCCEEE | 20.60 | 21440633 | |
| 72 | Succinylation | PSVVAFTKEGERLVG CCEEEEECCCCEEEC | 58.21 | 23954790 | |
| 72 | Acetylation | PSVVAFTKEGERLVG CCEEEEECCCCEEEC | 58.21 | 24489116 | |
| 83 | Succinylation | RLVGIPAKRQAVVNP EEECCCCCCCEECCC | 39.42 | 23954790 | |
| 98 | Acetylation | ENTLFATKRLIGRRF HHCHHHHHHHHCCCC | 41.60 | 24489116 | |
| 98 | Succinylation | ENTLFATKRLIGRRF HHCHHHHHHHHCCCC | 41.60 | 23954790 | |
| 115 | Acetylation | AEVQRDIKQVPYKIV HHHHHHHHHCCCEEE | 49.92 | 24489116 | |
| 115 | Succinylation | AEVQRDIKQVPYKIV HHHHHHHHHCCCEEE | 49.92 | 23954790 | |
| 120 | Acetylation | DIKQVPYKIVKHSNG HHHHCCCEEEECCCC | 34.65 | 24489116 | |
| 123 | Acetylation | QVPYKIVKHSNGDAW HCCCEEEECCCCCCE | 44.80 | 22865919 | |
| 125 | Phosphorylation | PYKIVKHSNGDAWVE CCEEEECCCCCCEEE | 36.47 | 21082442 | |
| 137 | Phosphorylation | WVEARGQTYSPAQIG EEEECCCEECHHHHC | 28.88 | 28889911 | |
| 138 | Phosphorylation | VEARGQTYSPAQIGG EEECCCEECHHHHCH | 12.55 | 26447709 | |
| 139 | Phosphorylation | EARGQTYSPAQIGGF EECCCEECHHHHCHH | 19.69 | 25752575 | |
| 161 | Succinylation | TAEAYLGKPVKNAVV HHHHHCCCCCCCEEE | 44.00 | 23954790 | |
| 161 | Acetylation | TAEAYLGKPVKNAVV HHHHHCCCCCCCEEE | 44.00 | 24489116 | |
| 173 | Phosphorylation | AVVTVPAYFNDSQRQ EEEEEECCCCHHHCC | 9.24 | 21440633 | |
| 177 | Phosphorylation | VPAYFNDSQRQATKD EECCCCHHHCCCCCC | 28.50 | 27214570 | |
| 183 | Succinylation | DSQRQATKDAGQIVG HHHCCCCCCHHCEEE | 48.90 | 23954790 | |
| 183 | Ubiquitination | DSQRQATKDAGQIVG HHHCCCCCCHHCEEE | 48.90 | 24961812 | |
| 183 | Acetylation | DSQRQATKDAGQIVG HHHCCCCCCHHCEEE | 48.90 | 24489116 | |
| 211 | Succinylation | ALAYGLEKSDSKVVA HHHHCCCCCCCEEEE | 65.68 | 23954790 | |
| 211 | Acetylation | ALAYGLEKSDSKVVA HHHHCCCCCCCEEEE | 65.68 | 24489116 | |
| 243 | Phosphorylation | NGVFEVKSTNGDTHL CCEEEEEECCCCCCC | 32.08 | 21440633 | |
| 268 | Succinylation | REIVSRFKTETGIDL HHHHHHHHCCCCCCC | 44.32 | 23954790 | |
| 268 | Acetylation | REIVSRFKTETGIDL HHHHHHHHCCCCCCC | 44.32 | 24489116 | |
| 269 | Phosphorylation | EIVSRFKTETGIDLE HHHHHHHCCCCCCCC | 35.75 | 28889911 | |
| 322 | Acetylation | GPKHINMKFSRAQFE CCCCEECEECHHHHH | 35.38 | 24489116 | |
| 330 | Phosphorylation | FSRAQFETLTAPLVK ECHHHHHHHHHHHHH | 30.60 | 12032075 | |
| 337 | Succinylation | TLTAPLVKRTVDPVK HHHHHHHHCCCHHHH | 50.46 | 23954790 | |
| 337 | Acetylation | TLTAPLVKRTVDPVK HHHHHHHHCCCHHHH | 50.46 | 24489116 | |
| 344 | Acetylation | KRTVDPVKKALKDAG HCCCHHHHHHHHHCC | 37.40 | 24489116 | |
| 344 | Succinylation | KRTVDPVKKALKDAG HCCCHHHHHHHHHCC | 37.40 | 23954790 | |
| 348 | Succinylation | DPVKKALKDAGLSTS HHHHHHHHHCCCCCC | 50.85 | 23954790 | |
| 348 | Acetylation | DPVKKALKDAGLSTS HHHHHHHHHCCCCCC | 50.85 | 24489116 | |
| 353 | Phosphorylation | ALKDAGLSTSDISEV HHHHCCCCCCCHHHH | 25.58 | 22369663 | |
| 354 | Phosphorylation | LKDAGLSTSDISEVL HHHCCCCCCCHHHHH | 35.15 | 21440633 | |
| 355 | Phosphorylation | KDAGLSTSDISEVLL HHCCCCCCCHHHHHH | 29.57 | 22369663 | |
| 358 | Phosphorylation | GLSTSDISEVLLVGG CCCCCCHHHHHHHCC | 27.00 | 22369663 | |
| 367 | Phosphorylation | VLLVGGMSRMPKVVE HHHHCCCCCCHHHHH | 28.80 | 22369663 | |
| 371 | Acetylation | GGMSRMPKVVETVKS CCCCCCHHHHHHHHH | 49.96 | 22865919 | |
| 377 | Acetylation | PKVVETVKSLFGKDP HHHHHHHHHHHCCCH | 49.19 | 24489116 | |
| 378 | Phosphorylation | KVVETVKSLFGKDPS HHHHHHHHHHCCCHH | 25.29 | 21440633 | |
| 382 | Acetylation | TVKSLFGKDPSKAVN HHHHHHCCCHHHCCC | 60.16 | 24489116 | |
| 382 | Succinylation | TVKSLFGKDPSKAVN HHHHHHCCCHHHCCC | 60.16 | 23954790 | |
| 385 | Phosphorylation | SLFGKDPSKAVNPDE HHHCCCHHHCCCHHH | 43.30 | 22369663 | |
| 444 | Succinylation | RNTTIPTKKSQIFST CCCCCCCCHHHHEEE | 45.10 | 23954790 | |
| 444 | Acetylation | RNTTIPTKKSQIFST CCCCCCCCHHHHEEE | 45.10 | 25381059 | |
| 446 | Phosphorylation | TTIPTKKSQIFSTAA CCCCCCHHHHEEECC | 30.02 | 27017623 | |
| 450 | Phosphorylation | TKKSQIFSTAAAGQT CCHHHHEEECCCCCC | 20.83 | 27017623 | |
| 451 | Phosphorylation | KKSQIFSTAAAGQTS CHHHHEEECCCCCCE | 15.01 | 27017623 | |
| 475 | Acetylation | RELVRDNKLIGNFTL CCEEECCEEEECEEE | 45.85 | 24489116 | |
| 481 | Phosphorylation | NKLIGNFTLAGIPPA CEEEECEEECCCCCC | 21.50 | 21126336 | |
| 514 | Acetylation | INVSARDKATNKDSS EEEEEECCCCCCCCC | 52.11 | 24489116 | |
| 516 | Phosphorylation | VSARDKATNKDSSIT EEEECCCCCCCCCEE | 48.84 | 19823750 | |
| 520 | Phosphorylation | DKATNKDSSITVAGS CCCCCCCCCEEEECC | 25.83 | 19823750 | |
| 521 | Phosphorylation | KATNKDSSITVAGSS CCCCCCCCEEEECCC | 32.20 | 19823750 | |
| 523 | Phosphorylation | TNKDSSITVAGSSGL CCCCCCEEEECCCCC | 13.27 | 24909858 | |
| 527 | Phosphorylation | SSITVAGSSGLSENE CCEEEECCCCCCHHH | 16.11 | 19823750 | |
| 528 | Phosphorylation | SITVAGSSGLSENEI CEEEECCCCCCHHHH | 42.72 | 19823750 | |
| 531 | Phosphorylation | VAGSSGLSENEIEQM EECCCCCCHHHHHHH | 41.73 | 19823750 | |
| 544 | Acetylation | QMVNDAEKFKSQDEA HHHHHHHHHCCHHHH | 60.87 | 24489116 | |
| 546 | Acetylation | VNDAEKFKSQDEARK HHHHHHHCCHHHHHH | 59.27 | 25381059 | |
| 561 | Acetylation | QAIETANKADQLAND HHHHHHHHHHHHHHH | 51.37 | 24489116 | |
| 572 | Phosphorylation | LANDTENSLKEFEGK HHHHHHHHHHHHCCC | 34.29 | 21440633 | |
| 574 | Succinylation | NDTENSLKEFEGKVD HHHHHHHHHHCCCCC | 61.24 | 23954790 | |
| 574 | Acetylation | NDTENSLKEFEGKVD HHHHHHHHHHCCCCC | 61.24 | 24489116 | |
| 579 | Succinylation | SLKEFEGKVDKAEAQ HHHHHCCCCCHHHHH | 39.81 | 23954790 | |
| 579 | Acetylation | SLKEFEGKVDKAEAQ HHHHHCCCCCHHHHH | 39.81 | 24489116 | |
| 582 | Acetylation | EFEGKVDKAEAQKVR HHCCCCCHHHHHHHH | 51.63 | 24489116 | |
| 587 | Acetylation | VDKAEAQKVRDQITS CCHHHHHHHHHHHHH | 46.41 | 25381059 | |
| 596 | Acetylation | RDQITSLKELVARVQ HHHHHHHHHHHHHHH | 49.09 | 24489116 | |
| 596 | Succinylation | RDQITSLKELVARVQ HHHHHHHHHHHHHHH | 49.09 | 23954790 | |
| 614 | Acetylation | EVNAEELKTKTEELQ CCCHHHHHHHHHHHH | 51.78 | 24489116 | |
| 616 | Acetylation | NAEELKTKTEELQTS CHHHHHHHHHHHHHH | 52.96 | 24489116 | |
| 623 | Phosphorylation | KTEELQTSSMKLFEQ HHHHHHHHHHHHHHH | 18.57 | 23749301 | |
| 626 | Acetylation | ELQTSSMKLFEQLYK HHHHHHHHHHHHHHH | 52.55 | 24489116 | |
| 633 | Acetylation | KLFEQLYKNDSNNNN HHHHHHHHCCCCCCC | 63.97 | 24489116 | |
| 636 | Phosphorylation | EQLYKNDSNNNNNNN HHHHHCCCCCCCCCC | 51.34 | 21440633 | |
| 649 | Phosphorylation | NNGNNAESGETKQ-- CCCCCCCCCCCCC-- | 39.25 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSP77_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSP77_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSP77_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-14; SER-16 ANDTHR-137, AND MASS SPECTROMETRY. | |
| "Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase."; Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.; Mol. Cell. Proteomics 6:1896-1906(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330, AND MASSSPECTROMETRY. | |