RTN2_YEAST - dbPTM
RTN2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RTN2_YEAST
UniProt AC Q12443
Protein Name Reticulon-like protein 2
Gene Name RTN2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 393
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MNRNTTTNKNANLNNSRNANAPGEAGHQNKTGLIYWTNPSKSGASFAATLVSLLILRNVNVISVLLKIGYMVLFTSFAVELSTKVLFDKGVVSRFGMQESPDLVGVLKPHIDRELDRLPALEDRIRKLVFAHRTRNNFTIGVSLYFLHGLFAIFSMNTVLIMTTIFLYTVPLIYDRKQARIDRAIDRMKDLVIHRFHKNYNKVVEKTEPYIDKIIPPQTDEGSYSTSISNENKSSTSQRNKSGLSSSEFDNMNDTSASKSGKDSYSTSQYNRAEYPVSQNENIGTLKSGKQEIPTEKDFNNRHENFSKPDVKTYDPRTVDIEEELAAHQRELEQNLKDGDYNLVGSKEIPDPITVPAPTRHTTKPAESQSIPIKNNETLHKTTHGLKQKLQHA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MNRNTTTNKNANLN
-CCCCCCCCCCCCCC		42.0030377154
137N-linked_GlycosylationFAHRTRNNFTIGVSL
HHHCCCCCCCCCEEH		31.95-
1892-HydroxyisobutyrylationDRAIDRMKDLVIHRF
HHHHHHHHHHHHHHH		49.13-
226PhosphorylationTDEGSYSTSISNENK
CCCCCCCCCCCCCCC		23.1128889911
227PhosphorylationDEGSYSTSISNENKS
CCCCCCCCCCCCCCC		20.3428889911
235PhosphorylationISNENKSSTSQRNKS
CCCCCCCCCCCCCCC		33.4227017623
242PhosphorylationSTSQRNKSGLSSSEF
CCCCCCCCCCCHHHH		48.8122369663
245PhosphorylationQRNKSGLSSSEFDNM
CCCCCCCCHHHHCCC		35.0322369663
246PhosphorylationRNKSGLSSSEFDNMN
CCCCCCCHHHHCCCC		38.6422369663
247PhosphorylationNKSGLSSSEFDNMND
CCCCCCHHHHCCCCC		38.6222369663
255PhosphorylationEFDNMNDTSASKSGK
HHCCCCCCCCCCCCC		22.6119684113
256PhosphorylationFDNMNDTSASKSGKD
HCCCCCCCCCCCCCC		33.1527017623
258PhosphorylationNMNDTSASKSGKDSY
CCCCCCCCCCCCCCC		27.4128889911
264PhosphorylationASKSGKDSYSTSQYN
CCCCCCCCCCCCCCC		25.1921440633
265PhosphorylationSKSGKDSYSTSQYNR
CCCCCCCCCCCCCCC		26.5427017623
266PhosphorylationKSGKDSYSTSQYNRA
CCCCCCCCCCCCCCC		26.0730377154
267PhosphorylationSGKDSYSTSQYNRAE
CCCCCCCCCCCCCCC		16.1828889911
268PhosphorylationGKDSYSTSQYNRAEY
CCCCCCCCCCCCCCC		25.4030377154
275PhosphorylationSQYNRAEYPVSQNEN
CCCCCCCCCCCCCCC		14.1429136822
278PhosphorylationNRAEYPVSQNENIGT
CCCCCCCCCCCCCCC		23.8429136822
285PhosphorylationSQNENIGTLKSGKQE
CCCCCCCCCCCCCCC		27.5029136822
297AcetylationKQEIPTEKDFNNRHE
CCCCCCCCCCCCCCC		70.8324489116
307PhosphorylationNNRHENFSKPDVKTY
CCCCCCCCCCCCCCC		55.6621440633
337AcetylationRELEQNLKDGDYNLV
HHHHHHHCCCCCCCC		68.1824489116
346PhosphorylationGDYNLVGSKEIPDPI
CCCCCCCCCCCCCCC		21.4528889911
363PhosphorylationPAPTRHTTKPAESQS
CCCCCCCCCCCCCCC		28.9830377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RTN2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RTN2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RTN2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLMT_YEASTOPI3genetic
16269340
CP51_YEASTERG11physical
18467557
RTN2_YEASTRTN2physical
18467557
LNP_YEASTLNP1genetic
22729086
CDC24_YEASTCDC24genetic
27708008
ERF3_YEASTSUP35genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CDC37_YEASTCDC37genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
SMD1_YEASTSMD1genetic
27708008
SN114_YEASTSNU114genetic
27708008
MED10_YEASTNUT2genetic
27708008
PTH2_YEASTPTH2genetic
27708008
CHK1_YEASTCHK1genetic
27708008
PRTD_YEASTPRD1genetic
27708008
MDM34_YEASTMDM34genetic
27708008
ENO1_YEASTENO1genetic
27708008
OSH3_YEASTOSH3genetic
27708008
LRP1_YEASTLRP1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
CWP2_YEASTCWP2genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ENV10_YEASTENV10genetic
27708008
FUMH_YEASTFUM1genetic
27708008
AXL1_YEASTAXL1genetic
27708008
ASNS1_YEASTASN1genetic
27708008
LNP_YEASTLNP1genetic
27117666
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RTN2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-278, ANDMASS SPECTROMETRY.

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