LYS4_YEAST - dbPTM
LYS4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LYS4_YEAST
UniProt AC P49367
Protein Name Homoaconitase, mitochondrial
Gene Name LYS4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 693
Subcellular Localization Mitochondrion .
Protein Description Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis..
Protein Sequence MLRSTTFTRSFHSSRAWLKGQNLTEKIVQSYAVNLPEGKVVHSGDYVSIKPAHCMSHDNSWPVALKFMGLGATKIKNPSQIVTTLDHDIQNKSEKNLTKYKNIENFAKKHHIDHYPAGRGIGHQIMIEEGYAFPLNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATGQTWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANMTTEWGALSGLFPVDKTLIDWYKNRLQKLGTNNHPRINPKTIRALEEKAKIPKADKDAHYAKKLIIDLATLTHYVSGPNSVKVSNTVQDLSQQDIKINKAYLVSCTNSRLSDLQSAADVVCPTGDLNKVNKVAPGVEFYVAAASSEIEADARKSGAWEKLLKAGCIPLPSGCGPCIGLGAGLLEPGEVGISATNRNFKGRMGSKDALAYLASPAVVAASAVLGKISSPAEVLSTSEIPFSGVKTEIIENPVVEEEVNAQTEAPKQSVEILEGFPREFSGELVLCDADNINTDGIYPGKYTYQDDVPKEKMAQVCMENYDAEFRTKVHPGDIVVSGFNFGTGSSREQAATALLAKGINLVVSGSFGNIFSRNSINNALLTLEIPALIKKLREKYQGAPKELTRRTGWFLKWDVADAKVVVTEGSLDGPVILEQKVGELGKNLQEIIVKGGLEGWVKSQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26UbiquitinationKGQNLTEKIVQSYAV
HCCCHHHHHHHHHCC		42.8315699485
39UbiquitinationAVNLPEGKVVHSGDY
CCCCCCCCEEECCCE		39.1515699485
76AcetylationGLGATKIKNPSQIVT
CCCCCCCCCHHHHEE		65.4522865919
92AcetylationLDHDIQNKSEKNLTK
ECHHHCCCCCCCCHH		43.5524489116
95AcetylationDIQNKSEKNLTKYKN
HHCCCCCCCCHHHHC		65.4325381059
101AcetylationEKNLTKYKNIENFAK
CCCCHHHHCHHHHHH		53.6725381059
108AcetylationKNIENFAKKHHIDHY
HCHHHHHHHHCCCCC		48.8025381059
258AcetylationKTLIDWYKNRLQKLG
HHHHHHHHHHHHHHC		31.1924489116
321PhosphorylationNSVKVSNTVQDLSQQ
CCCCEECCCHHHHHC		16.4328889911
340GlutathionylationNKAYLVSCTNSRLSD
CEEEEEECCCCCHHH		3.0522833525
356GlutathionylationQSAADVVCPTGDLNK
HHHCCEECCCCCHHH		2.2222833525
363UbiquitinationCPTGDLNKVNKVAPG
CCCCCHHHHCCCCCC		55.2515699485
439AcetylationFKGRMGSKDALAYLA
CCCCCCCHHHHHHHH		41.0924489116
542AcetylationTYQDDVPKEKMAQVC
CCCCCCCHHHHHHHH		70.5725381059
622AcetylationLEIPALIKKLREKYQ
HHHHHHHHHHHHHHC		46.7524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LYS4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LYS4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LYS4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF5A1_YEASTHYP2physical
16554755
ZUO1_YEASTZUO1physical
16554755
SSZ1_YEASTSSZ1physical
16554755
HS104_YEASTHSP104physical
16554755
GLYC_YEASTSHM2physical
16554755
EF3A_YEASTYEF3physical
16554755
EF1G1_YEASTCAM1physical
16554755
KYNU_YEASTBNA5genetic
16941010
KMO_YEASTBNA4genetic
16941010
I23O_YEASTBNA2genetic
16941010
SDH3_YEASTSDH3genetic
16941010
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LYS4_YEAST

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Related Literatures of Post-Translational Modification

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