dbPTM

SDH3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SDH3_YEAST
UniProt AC	P33421
Protein Name	Succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
Gene Name	SDH3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	198
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction..
Protein Sequence	MSAMMVKLGLNKSALLLKPSAFSRAAALSSSRRLLFNTARTNFLSTSPLKNVASEMNTKAAIAEEQILNKQRAKRPISPHLTIYQPQLTWYLSSLHRISLVLMGLGFYLFTILFGVSGLLGLGLTTEKVSNWYHQKFSKITEWSIKGSFAYLFAIHYGGAIRHLIWDTAKELTLKGVYRTGYALIGFTAVLGTYLLTL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
45	Phosphorylation	TARTNFLSTSPLKNV HHCCCCCCCCCHHHH	23.77	27017623
70	Acetylation	AEEQILNKQRAKRPI HHHHHHHHHHCCCCC	37.40	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SDH3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SDH3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SDH3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHSD_YEAST	SDH4	physical	18313953
PYRD_YEAST	URA1	genetic	16941010
ATPA_YEAST	ATP1	genetic	21623372
IDH2_YEAST	IDH2	genetic	21623372
6PGD1_YEAST	GND1	genetic	21623372
ERG2_YEAST	ERG2	genetic	21623372
THRC_YEAST	THR4	genetic	21623372
POS5_YEAST	POS5	genetic	21623372
SOL4_YEAST	SOL4	genetic	21623372
ADH3_YEAST	ADH3	genetic	21623372
SSU1_YEAST	SSU1	genetic	21623372
CYS3_YEAST	CYS3	genetic	21623372
THI20_YEAST	THI20	genetic	21623372
SKN1_YEAST	SKN1	genetic	21623372
FUMH_YEAST	FUM1	genetic	21623372
QCR9_YEAST	QCR9	genetic	21623372
CHMU_YEAST	ARO7	genetic	21623372
DPP1_YEAST	DPP1	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
GLG1_YEAST	GLG1	genetic	21623372
PUR1_YEAST	ADE4	genetic	21623372
COX6_YEAST	COX6	genetic	21623372
TMT1_YEAST	TMT1	genetic	21623372
SUR1_YEAST	SUR1	genetic	21623372
FTHC_YEAST	FAU1	genetic	21623372
ALDH3_YEAST	ALD3	genetic	21623372
QCR6_YEAST	QCR6	genetic	21623372
GAL2_YEAST	GAL2	genetic	21623372
DHOM_YEAST	HOM6	genetic	21623372
SPEE_YEAST	SPE3	genetic	21623372
FMS1_YEAST	FMS1	genetic	21623372
ATP5E_YEAST	ATP15	genetic	21623372
METC_YEAST	IRC7	genetic	21623372
SHH4_YEAST	SHH4	physical	22152483
DHSD_YEAST	SDH4	physical	22152483
TIM10_YEAST	TIM10	physical	22152483
TIM18_YEAST	TIM18	physical	22152483
TIM22_YEAST	TIM22	physical	22152483
SHH3_YEAST	SHH3	genetic	22573324
SHH4_YEAST	SHH4	physical	25328978

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SDH3_YEAST

Related Literatures of Post-Translational Modification