SSU1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSU1_YEAST
• UniProt AC: P41930
• Protein Name: Sulfite efflux pump SSU1
• Gene Name: SSU1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 458
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in efflux of free sulfite. Mutations in the SSU1 gene cause sensitivity to sulfite..
• Protein Sequence: MVANWVLALTRQFDPFMFMMVMGVGISSNILYSFPYPARWLRICSYIMFAIACLIFIAVQALQILHLIVYIKEKSFREYFNDFFRNMKHNLFWGTYPMGLVTIINFLGALSKANTTKSPTNARNLMIFVYVLWWYDLAVCLVIAWGISFLIWHDYYPLEGIGNYPSYNIKMASENMKSVLLLDIIPLVVVASSCGTFTMSEIFFHAFNRNIQLITLVICALTWLHAIIFVFILIAIYFWSLYINKIPPMTQVFTLFLLLGPMGQGSFGVLLLTDNIKKYAGKYYPTDNITREQEILTIAVPWCFKILGMVSAMALLAMGYFFTVISVVSILSYYNKKEIENETGKVKRVYTFHKGFWGMTFPMGTMSLGNEELYVQYNQYVPLYAFRVLGTIYGGVCVCWSILCLLCTLHEYSKKMLHAARKSSLFSESGTEKTTVSPYNSIESVEESNSALDFTRLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
282	Ubiquitination	NIKKYAGKYYPTDNI CHHHHCCCCCCCCCC	33.18	23749301
345	Ubiquitination	EIENETGKVKRVYTF HHCCCCCCEEEEEEE	52.59	23749301
427	Phosphorylation	ARKSSLFSESGTEKT HHHHHCCCCCCCCCC	35.82	22369663
429	Phosphorylation	KSSLFSESGTEKTTV HHHCCCCCCCCCCCC	50.22	22369663
431	Phosphorylation	SLFSESGTEKTTVSP HCCCCCCCCCCCCCC	43.52	22369663
434	Phosphorylation	SESGTEKTTVSPYNS CCCCCCCCCCCCCCC	26.63	22369663
435	Phosphorylation	ESGTEKTTVSPYNSI CCCCCCCCCCCCCCC	30.01	22369663
437	Phosphorylation	GTEKTTVSPYNSIES CCCCCCCCCCCCCCC	21.41	22369663
439	Phosphorylation	EKTTVSPYNSIESVE CCCCCCCCCCCCCHH	17.65	21440633
441	Phosphorylation	TTVSPYNSIESVEES CCCCCCCCCCCHHHH	23.14	22369663
444	Phosphorylation	SPYNSIESVEESNSA CCCCCCCCHHHHCCC	32.91	22369663
448	Phosphorylation	SIESVEESNSALDFT CCCCHHHHCCCCCHH	23.68	22369663
450	Phosphorylation	ESVEESNSALDFTRL CCHHHHCCCCCHHCC	39.22	22369663
455	Phosphorylation	SNSALDFTRLA---- HCCCCCHHCCC----	25.17	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSU1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSU1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSU1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAPS_YEAST	MET14	genetic	11921096
MRM2_YEAST	MRM2	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
PEX19_YEAST	PEX19	genetic	27708008
ATG9_YEAST	ATG9	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
FABG_YEAST	OAR1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; SER-441; SER-444;SER-448 AND SER-450, AND MASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429, AND MASSSPECTROMETRY.
PubMed: 17563356