PEX19_YEAST - dbPTM
PEX19_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX19_YEAST
UniProt AC Q07418
Protein Name Peroxisomal membrane protein import receptor PEX19
Gene Name PEX19
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 342
Subcellular Localization Cytoplasm . Peroxisome membrane
Lipid-anchor
Cytoplasmic side . Endoplasmic reticulum membrane . Predominantly cytoplasmic (PubMed:9418908). Concentrates in a PEX3-dependent manner to defined foci on the endoplasmic reticulum membrane, which then
Protein Description Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer. Directs PEX17, a peripheral component of the peroxisomal matrix protein translocation machinery, to peroxisomes. Stabilizes VPS1, a protein required for peroxisomal fission, at the peroxisomal membrane. Also acts in conjunction with PEX3 in the formation of peroxisomes from preperoxisomal compartments at the endoplasmic reticulum during de novo peroxisome synthesis, probably via the import of additional PMPs..
Protein Sequence MNENEYDNFDDLDDLLDEDPTKLDEAEPDDVQAKGSVYNDSENKEKNAESKDSDGVQVANESEEDPELKEMMVDLQNEFANLMKNNGNENNVKTEDFNKLISALEEAAKVPHQQMEQGCSSLKSNSTDKGTVNGSNPGFKNIVSNTLDRLKENGNKVDTSLAEETKESQRSGQNNNIDDILSQLLDQMVASGGKESAENQFDLKDGEMDDAITKILDQMTSKEVLYEPMKEMRSEFGVWFQENGENEEHKEKIGTYKRQFNIVDEIVNIYELKDYDELKHKDRVTELLDELEQLGDSPIRSANSPLKHGNEEEELMKMLEIDGNDPNLGNLDKELTDGCKQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationDDVQAKGSVYNDSEN
CCCCCCCCCCCCCCC		22.2622369663
38PhosphorylationVQAKGSVYNDSENKE
CCCCCCCCCCCCCCH		18.2322369663
41PhosphorylationKGSVYNDSENKEKNA
CCCCCCCCCCCHHCC		39.1622369663
50PhosphorylationNKEKNAESKDSDGVQ
CCHHCCCCCCCCCCC		39.0822369663
53PhosphorylationKNAESKDSDGVQVAN
HCCCCCCCCCCCCCC		39.7522890988
62PhosphorylationGVQVANESEEDPELK
CCCCCCCCCCCHHHH		46.2022369663
93UbiquitinationNGNENNVKTEDFNKL
CCCCCCCCHHHHHHH		48.6023749301
99UbiquitinationVKTEDFNKLISALEE
CCHHHHHHHHHHHHH		47.3824961812
120PhosphorylationQQMEQGCSSLKSNST
HHHHHHHHHCCCCCC		45.5930377154
121PhosphorylationQMEQGCSSLKSNSTD
HHHHHHHHCCCCCCC		43.8421440633
123AcetylationEQGCSSLKSNSTDKG
HHHHHHCCCCCCCCC		49.9225381059
124PhosphorylationQGCSSLKSNSTDKGT
HHHHHCCCCCCCCCC		41.1121440633
126PhosphorylationCSSLKSNSTDKGTVN
HHHCCCCCCCCCCCC		45.1121440633
127PhosphorylationSSLKSNSTDKGTVNG
HHCCCCCCCCCCCCC		46.0821440633
129UbiquitinationLKSNSTDKGTVNGSN
CCCCCCCCCCCCCCC		57.4823749301
131PhosphorylationSNSTDKGTVNGSNPG
CCCCCCCCCCCCCCC		19.2822369663
135PhosphorylationDKGTVNGSNPGFKNI
CCCCCCCCCCCHHHH		34.3522369663
204UbiquitinationAENQFDLKDGEMDDA
HHCCCCCCCCCHHHH		66.5823749301
222AcetylationILDQMTSKEVLYEPM
HHHHHCCHHHHHHHH		42.5524489116
297PhosphorylationELEQLGDSPIRSANS
HHHHHCCCCCCCCCC		22.0421440633
301PhosphorylationLGDSPIRSANSPLKH
HCCCCCCCCCCCCCC		32.3029136822
304PhosphorylationSPIRSANSPLKHGNE
CCCCCCCCCCCCCCH		31.1817330950
339MethylationDKELTDGCKQQ----
CHHHCHHHCCC----		3.91-
339FarnesylationDKELTDGCKQQ----
CHHHCHHHCCC----		3.919418908
339FarnesylationDKELTDGCKQQ----
CHHHCHHHCCC----		3.919418908
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX19_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX19_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX19_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX3_YEASTPEX3physical
9418908
INP2_YEASTINP2physical
16678774
PEX11_YEASTPEX11physical
18467557
PEX25_YEASTPEX25physical
18467557
PEX14_YEASTPEX14physical
18467557
PEX13_YEASTPEX13physical
18467557
PEX3_YEASTPEX3physical
19948495
PEX5_YEASTPEX5physical
12876220
MYO2_YEASTMYO2physical
22486971
PEX13_YEASTPEX13physical
19451657
PEX25_YEASTPEX25physical
19451657
PEX12_YEASTPEX12physical
19451657
PEX17_YEASTPEX17physical
19451657
PEX27_YEASTPEX27physical
19451657
ANT1_YEASTANT1physical
19451657
PEX13_YEASTPEX13genetic
23891562
PEX1_YEASTPEX1genetic
23891562
PEX8_YEASTPEX8genetic
23891562
PEX2_YEASTPEX2genetic
23891562
PEX12_YEASTPEX12genetic
23891562
TVP18_YEASTTVP18genetic
23891562
AB1D_ARATHPXA1physical
22710125
MAK16_YEASTMAK16genetic
27708008
TFB1_YEASTTFB1genetic
27708008
UTP6_YEASTUTP6genetic
27708008
RSP5_YEASTRSP5genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRP19_YEASTPRP19genetic
27708008
TIM14_YEASTPAM18genetic
27708008
NOP56_YEASTNOP56genetic
27708008
CAP_YEASTSRV2genetic
27708008
CH10_YEASTHSP10genetic
27708008
DED1_YEASTDED1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ODPB_YEASTPDB1genetic
27708008
TXTP_YEASTCTP1genetic
27708008
ODO2_YEASTKGD2genetic
27708008
DHAS_YEASTHOM2genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
BLM10_YEASTBLM10genetic
27708008
HTD2_YEASTHTD2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
PFD6_YEASTYKE2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
BUL2_YEASTBUL2genetic
27708008
PET8_YEASTPET8genetic
27708008
LIPA_YEASTLIP5genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX19_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-62 AND SER-304,AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, AND MASSSPECTROMETRY.
Prenylation
ReferencePubMed
"Pex19p, a farnesylated protein essential for peroxisome biogenesis.";
Goette K., Girzalsky W., Linkert M., Baumgart E., Kammerer S.,Kunau W.-H., Erdmann R.;
Mol. Cell. Biol. 18:616-628(1998).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH PEX3,INDUCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-339, ANDISOPRENYLATION AT CYS-339.

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