dbPTM

TVP18_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TVP18_YEAST
UniProt AC	Q04767
Protein Name	Golgi apparatus membrane protein TVP18
Gene Name	TVP18
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	167
Subcellular Localization	Golgi apparatus membrane Multi-pass membrane protein .
Protein Description	Golgi membrane protein involved in vesicular trafficking..
Protein Sequence	MALSLGQFINVGGMVKDLKSFNFSVYGRWFGYINIILCIALGIANLFHVSGVIAFGIISIIQGLVILFIEIPFLLKICPLSDNFIEFIKRFETNGWRCLFYLAMAIIQYISIAVMATSLIVVAVGLTISSISYAVAYTKHQEFQNTNIIKNPTDDDFPHEAVVREML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	N-linked_Glycosylation	VKDLKSFNFSVYGRW HCCHHHCCCEEHHHH	35.06	-
146	Phosphorylation	KHQEFQNTNIIKNPT CCCCCCCCCCCCCCC	19.60	28889911
150	Ubiquitination	FQNTNIIKNPTDDDF CCCCCCCCCCCCCCC	53.75	23749301
153	Phosphorylation	TNIIKNPTDDDFPHE CCCCCCCCCCCCCHH	62.55	17330950

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TVP18_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TVP18_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TVP18_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALM_YEAST	CMD1	physical	16554755
MLC1_YEAST	MLC1	physical	16554755
MYO2_YEAST	MYO2	physical	16554755
TVP15_YEAST	TVP15	physical	17178117
UIP3_YEAST	UIP3	physical	18719252
PEX29_YEAST	PEX29	physical	18719252
VPS41_YEAST	VPS41	genetic	20093466
MSH4_YEAST	MSH4	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
MUP1_YEAST	MUP1	genetic	20093466
THIK_YEAST	POT1	genetic	20093466
UBI4P_YEAST	UBI4	genetic	20093466
ERG3_YEAST	ERG3	genetic	20093466
ATG3_YEAST	ATG3	genetic	20093466
TRM11_YEAST	TRM11	genetic	20093466
MSN1_YEAST	MSN1	genetic	20093466
VPS17_YEAST	VPS17	genetic	20093466
TBP6_YEAST	YTA6	genetic	20093466
YP089_YEAST	YPR089W	genetic	20093466
COG3_YEAST	COG3	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
CDC48_YEAST	CDC48	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
SAD1_YEAST	SAD1	genetic	27708008
CP51_YEAST	ERG11	genetic	27708008
MPPA_YEAST	MAS2	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
MCM10_YEAST	MCM10	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
SN114_YEAST	SNU114	genetic	27708008
SMC4_YEAST	SMC4	genetic	27708008
ERG27_YEAST	ERG27	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
HRP1_YEAST	HRP1	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
SMP3_YEAST	SMP3	genetic	27708008
RPN7_YEAST	RPN7	genetic	27708008
MED10_YEAST	NUT2	genetic	27708008
ATG9_YEAST	ATG9	genetic	27708008
MSH4_YEAST	MSH4	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
UBI4P_YEAST	UBI4	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
EIF3J_YEAST	HCR1	genetic	27708008
ATG3_YEAST	ATG3	genetic	27708008
MSN1_YEAST	MSN1	genetic	27708008
TRM11_YEAST	TRM11	genetic	27708008
VPS17_YEAST	VPS17	genetic	27708008
DGK1_YEAST	DGK1	genetic	27708008
PMA2_YEAST	PMA2	genetic	27708008
TBP6_YEAST	YTA6	genetic	27708008
BECN1_YEAST	VPS30	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TVP18_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, AND MASSSPECTROMETRY.	17330950 [Abstract]