MPPA_YEAST - dbPTM
MPPA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPPA_YEAST
UniProt AC P11914
Protein Name Mitochondrial-processing peptidase subunit alpha
Gene Name MAS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 482
Subcellular Localization Mitochondrion matrix.
Protein Description Cleaves presequences (transit peptides) from mitochondrial protein precursors. The cleavage sites typically contain an arginine at position -2 (in the N-terminal portion) from the scissible peptide bond in addition to other distal basic residues, and an aromatic residue at position +1..
Protein Sequence MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNTPGHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSRENLMYQASVFNQDVGKMLQLMSETVRFPKITEQELQEQKLSAEYEIDEVWMKPELVLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVGVPHEKALELTEKYLGDWQSTHPPITKKVAQYTGGESCIPPAPVFGNLPELFHIQIGFEGLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSDSGIFGISLSCIPQAAPQAVEVIAQQMYNTFANKDLRLTEDEVSRAKNQLKSSLLMNLESKLVELEDMGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEMIFTGNVNNAGNGKGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20AcetylationIARTDNFKLSSLANG
HHCCCCCCHHHHHCC		54.4324489116
35PhosphorylationLKVATSNTPGHFSAL
CEEECCCCCCCCEEE		30.3430377154
40PhosphorylationSNTPGHFSALGLYID
CCCCCCCEEEEEEEE		19.5330377154
45PhosphorylationHFSALGLYIDAGSRF
CCEEEEEEEECCCCC		8.5830377154
50PhosphorylationGLYIDAGSRFEGRNL
EEEEECCCCCCCCCC		35.2030377154
184AcetylationELIPSISKYYLLDYR
HHCCCCCEEEEEECC		35.9222865919
193AcetylationYLLDYRNKFYTPENT
EEEECCCCCCCCCCC		30.6524489116
211AcetylationFVGVPHEKALELTEK
ECCCCHHHHHHHHHH		56.0624489116
218AcetylationKALELTEKYLGDWQS
HHHHHHHHHHCCHHH		40.3124489116
226PhosphorylationYLGDWQSTHPPITKK
HHCCHHHCCCCCCHH		24.2528889911
231PhosphorylationQSTHPPITKKVAQYT
HHCCCCCCHHHHHHH		30.5028889911
411AcetylationPVNEMISKIEDLKPD
CHHHHHHHHHHCCHH		38.9124489116
416AcetylationISKIEDLKPDDISRV
HHHHHHCCHHHHHHH		59.7424489116
461AcetylationGDVENVLKAYGLGNS
CCHHHHHHHHCCCCC		34.9724489116
475PhosphorylationSSSSKNDSPKKKGWF
CCCCCCCCCCCCCCC		48.2721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPPA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPPA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPPA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPPB_YEASTMAS1physical
2007593
MPPB_YEASTMAS1physical
16554755
ATG2_YEASTATG2physical
16554755
MPPB_YEASTMAS1physical
16429126
SSB1_YEASTSSB1physical
19536198
MRM2_YEASTMRM2genetic
27708008
YRA2_YEASTYRA2genetic
27708008
INO4_YEASTINO4genetic
27708008
POP7_YEASTPOP7genetic
27708008
APC11_YEASTAPC11genetic
27708008
SNU56_YEASTSNU56genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
MPPB_YEASTMAS1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
CH10_YEASTHSP10genetic
27708008
DYR_YEASTDFR1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
RPN7_YEASTRPN7genetic
27708008
CSG2_YEASTCSG2genetic
27708008
MBA1_YEASTMBA1genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SLX5_YEASTSLX5genetic
27708008
CHO2_YEASTCHO2genetic
27708008
ERG3_YEASTERG3genetic
27708008
MDL1_YEASTMDL1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
RCF2_YEASTRCF2genetic
27708008
PDE2_YEASTPDE2genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPPA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226 AND THR-231, ANDMASS SPECTROMETRY.

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