ATG2_YEAST - dbPTM
ATG2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG2_YEAST
UniProt AC P53855
Protein Name Autophagy-related protein 2
Gene Name ATG2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1592
Subcellular Localization Preautophagosomal structure membrane
Peripheral membrane protein . ATG1 and ATG9 are required for the proper localization the PAS.
Protein Description Required for cytoplasm to vacuole transport (Cvt) vesicle and autophagosome completion. Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9. Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation. ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process. Plays a significant role in life span extension..
Protein Sequence MAFWLPQNIQKRLLLYVLQQISLFSNIDLSNLDVSIGSKSHFSFHDVNLSLDDLNIPNVQINEGIVDELVLKLTVSGGVEIDGSGLRFIMTPLYSSGSQELHSDFLVKSIQDLTNSMLQFSDPLTTYNRYKEDDISSSDSSSDLNSNIEASKPAANGSYTLQNMRNKALNVALAKLKIALKDVTIRFIVNDRDPSDNIVEVHLESIQLITTDANLRHINIENITISSIQKQAVPDSPVHPFNNDDLSQSVYLSKMEATSLYMSAMEEQSNEDPSEPQVTQEEQENDKCKESLMEINNLNIAFKGLSSVNDLRMSNIVIDIQDVHLAIHKIVEIKNSTLKNIIDIIVTHLDANESFSCQDSQSPSPDKQEPSALSSVDIKCIYLNLGQDITVILKSFKLEQKENNSLAFSLGSFYSNSSPLTISHKTKPLLTGEQTPQSIALNMGDELDIIISHDGIAHFFKIFQFVSKCMSFYQNKSKGMMPQIASDTKRTVQLTSKAVKLSLKFPYFLLCFQVSPFIYDSNRELYIELVDVFKKLPSRCTKILTMSSITISNLQSPLQLGSYDDTLKEALIYSSVHAIIKEVIFNEEYSGIVQLVEDISAFGKLFTDSKNSECTGKSKSKRGSFLQRSVRVLNSSRFVYKQSLSANFSLKIDSMKLKVSEIIGPQFGSVEALLSNNFFAITDDSQIVYFTKNLKVERKTPSLLEPQEIMSVVLNKAVNEPVLYVHRRANGKLKVIFNNIRIHYYARWLEILKKNIGPDNASSKDEPVSQKLSKKQPTSGFPWELKCLDCSLILHPFRLKSVMVIVLDNLTTGGSSFIPQAKLLSKANTLFLIDDYQNFKIQKDKNWPSLINFYAGQGFSAIGKIDTLNFLINKSDGALLLDCKIEQVGLSLCADSFQTFCQLCIDLKYPQTFPDEEKFRTQLKNPIDVFKDIDCDLFNSAFIRENNHQNDYDSVHLVDSFLDKTHEFNNGARSKLSSQGSYEMDSSSGTATGGILLPHESYLDSAQPKEEDTPPIASKEQERDVDIRGSIDVEKVVIKLFDGYDWKYTRKFIANTVEKLDKELSKAEASSSKSNVPQSEANIFDSIYISANKNNVTDLRRNLDGEIQGVQNSFSDVSKVNLRPSKHYKALIQLNKVHVNLKNYRVDEPDESNSDNSTDVLNRCVVSIYEFEIIDNVPTSTWNKFVTLLKHEPWPHSSPMFLLDLEFIRPIDFLQAVELVMQLNVAPLRLHVDQDTLEFLIRFLGFKDKRFELIDEYPDIVFIQKFSTNSIKLRLDYKPKKVDYAGLRSGQTSELMNFFTLDGSKIILKSVVLYGLNGFDELNNKLKAIWTPDITKKQLPGVLEGLAPVRSFMAIGSGVKTLVTVLMSEYRQEGHLGRSLKKGGNVFLKTTTGDFVKLGVKLTSGTQAILENTEELFGGVGSNGRVYDASKFGSADGADSDTAAVLDLDTLFEEDQLVGSKYSRIRDHEPTAVVIDMSSPGDHNEPTIVSLYADQPLDLPTGLKEAYSSLEKHMHIAYDAVWRAKGQMKDDKRGGPSAAAVYVARAAPVAIIRPLIGATEAVSKTLQGIANQVDKTHNEQINDKYKSNRTDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11AcetylationWLPQNIQKRLLLYVL
CCCHHHHHHHHHHHH		41.0125381059
137PhosphorylationYKEDDISSSDSSSDL
CCCCCCCCCCCCCCC		38.2028889911
140PhosphorylationDDISSSDSSSDLNSN
CCCCCCCCCCCCHHC		33.4221551504
142PhosphorylationISSSDSSSDLNSNIE
CCCCCCCCCCHHCCC		50.5021551504
236PhosphorylationQKQAVPDSPVHPFNN
HHCCCCCCCCCCCCC		23.8122369663
247PhosphorylationPFNNDDLSQSVYLSK
CCCCCCCCHHHHHHH		27.6622369663
249PhosphorylationNNDDLSQSVYLSKME
CCCCCCHHHHHHHHH		14.8924961812
253PhosphorylationLSQSVYLSKMEATSL
CCHHHHHHHHHHHHH		16.5724961812
334AcetylationIHKIVEIKNSTLKNI
HHHHHHCCCCHHHHH		31.1924489116
496PhosphorylationKRTVQLTSKAVKLSL
CHHHHHCCHHHHHHH		27.4928889911
515PhosphorylationFLLCFQVSPFIYDSN
HHHEEECCEEEECCC		11.8727017623
519PhosphorylationFQVSPFIYDSNRELY
EECCEEEECCCCCEE		17.4427017623
521PhosphorylationVSPFIYDSNRELYIE
CCEEEECCCCCEEEE		22.3327017623
645PhosphorylationFVYKQSLSANFSLKI
CEEEEECCCCEEEEE		26.8127017623
762PhosphorylationNIGPDNASSKDEPVS
HCCCCCCCCCCCCHH		44.1430377154
940PhosphorylationIDCDLFNSAFIRENN
CCCCHHCCCHHCCCC		19.7427214570
954PhosphorylationNHQNDYDSVHLVDSF
CCCCCCCEEHHHHHH		12.7625704821
990PhosphorylationEMDSSSGTATGGILL
EECCCCCCCCCCEEE		24.0021440633
1047AcetylationLFDGYDWKYTRKFIA
ECCCCCHHHHHHHHH		33.5724489116
1056PhosphorylationTRKFIANTVEKLDKE
HHHHHHHHHHHHHHH		22.4830377154
1113PhosphorylationEIQGVQNSFSDVSKV
CEEHHHCCCCCHHCC		14.7228889911
1115PhosphorylationQGVQNSFSDVSKVNL
EHHHCCCCCHHCCCC		36.6028889911
1118PhosphorylationQNSFSDVSKVNLRPS
HCCCCCHHCCCCCCC		35.5626447709
1154PhosphorylationDEPDESNSDNSTDVL
CCCCCCCCCCHHHHH		47.6623749301
1277PhosphorylationSIKLRLDYKPKKVDY
CEEEEEECCCCCCCC		33.5128889911
1351PhosphorylationEGLAPVRSFMAIGSG
CCCCCHHHHHHHCCC		21.4321440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG18_YEASTATG18physical
18586673
ATG18_YEASTATG18physical
17295840
VATB_YEASTVMA2genetic
21987634
CISY2_YEASTCIT2genetic
21987634
ZUO1_YEASTZUO1genetic
21987634
NFU1_YEASTNFU1genetic
21987634
IPYR2_YEASTPPA2genetic
21987634
IDH2_YEASTIDH2genetic
21987634
ATG18_YEASTATG18physical
21887408
ATG9_YEASTATG9physical
21887408
ATG18_YEASTATG18physical
23230146
COPG_YEASTSEC21physical
23904270
SPO14_YEASTSPO14physical
23904270
YOP1_YEASTYOP1physical
23904270
YPT7_YEASTYPT7physical
23904270
CASP_YEASTCOY1physical
23904270
ATC1_YEASTPMR1physical
23904270
SEC23_YEASTSEC23physical
23904270
SNF7_YEASTSNF7physical
23904270
TVP38_YEASTTVP38physical
23904270
VPS21_YEASTVPS21physical
23904270
PRA1_YEASTYIP3physical
23904270
CDC48_YEASTCDC48physical
23904270
SSO1_YEASTSSO1physical
23904270
VPS1_YEASTVPS1physical
23904270
VTI1_YEASTVTI1physical
23904270
ATG13_YEASTATG13physical
23904270
SFT2_YEASTSFT2physical
23904270
FKS1_YEASTFKS1physical
23904270
ATG18_YEASTATG18physical
23904270
AKR1_YEASTAKR1physical
23904270
EXO84_YEASTEXO84genetic
27708008
CDK1_YEASTCDC28genetic
27708008
GPI19_YEASTGPI19genetic
27708008
CDC20_YEASTCDC20genetic
27708008
SMD1_YEASTSMD1genetic
27708008
YIP1_YEASTYIP1genetic
27708008
PAN1_YEASTPAN1genetic
27708008
POB3_YEASTPOB3genetic
27708008
PSA4_YEASTPRE6genetic
27708008
SGT1_YEASTSGT1genetic
27708008
SMP3_YEASTSMP3genetic
27708008
GPI2_YEASTGPI2genetic
27708008
IF6_YEASTTIF6genetic
27708008
ERG3_YEASTERG3genetic
27708008
SST2_YEASTSST2genetic
27708008
STU1_YEASTSTU1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
ALG1_YEASTALG1genetic
27708008
POP7_YEASTPOP7genetic
27708008
MCM7_YEASTMCM7genetic
27708008
MCES_YEASTABD1genetic
27708008
SCC1_YEASTMCD1genetic
27708008
FBRL_YEASTNOP1genetic
27708008
CDC7_YEASTCDC7genetic
27708008
MPS1_YEASTMPS1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
PRP11_YEASTPRP11genetic
27708008
FAD1_YEASTFAD1genetic
27708008
USO1_YEASTUSO1genetic
27708008
UBC9_YEASTUBC9genetic
27708008
KIN28_YEASTKIN28genetic
27708008
CDC48_YEASTCDC48genetic
27708008
TIM22_YEASTTIM22genetic
27708008
YRB1_YEASTYRB1genetic
27708008
PSF1_YEASTPSF1genetic
27708008
DAD1_YEASTDAD1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
STN1_YEASTSTN1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
SRPR_YEASTSRP101genetic
27708008
RSC3_YEASTRSC3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
CCA1_YEASTCCA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
PRS8_YEASTRPT6genetic
27708008
MCE1_YEASTCEG1genetic
27708008
TIM16_YEASTPAM16genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NNF1_YEASTNNF1genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SYFB_YEASTFRS1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC25_YEASTCDC25genetic
27708008
BET5_YEASTBET5genetic
27708008
HMCS_YEASTERG13genetic
27708008
LST8_YEASTLST8genetic
27708008
MED4_YEASTMED4genetic
27708008
RAEP_YEASTMRS6genetic
27708008
CET1_YEASTCET1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SEC23_YEASTSEC23genetic
27708008
MDM10_YEASTMDM10genetic
27708008
SLA1_YEASTSLA1genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
HAL4_YEASTSAT4genetic
27708008
MTU1_YEASTSLM3genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
LDB17_YEASTLDB17genetic
27708008
FOB1_YEASTFOB1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
SHE9_YEASTSHE9genetic
27708008
AIM11_YEASTAIM11genetic
27708008
PT122_YEASTPET122genetic
27708008
BUD27_YEASTBUD27genetic
27708008
EFM1_YEASTEFM1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
EMC5_YEASTEMC5genetic
27708008
TED1_YEASTTED1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
FLX1_YEASTFLX1genetic
27708008
MGA2_YEASTMGA2genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
CYT2_YEASTCYT2genetic
27708008
GAP1_YEASTGAP1genetic
27708008
NU133_YEASTNUP133genetic
27708008
FPS1_YEASTFPS1genetic
27708008
HOG1_YEASTHOG1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
MMS22_YEASTMMS22genetic
27708008
VID22_YEASTVID22genetic
27708008
PUN1_YEASTPUN1genetic
27708008
RM39_YEASTMRPL39genetic
27708008
VPS71_YEASTVPS71genetic
27708008
DATI_YEASTDAT1genetic
27708008
PGM3_YEASTPRM15genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
CYB5_YEASTCYB5genetic
27708008
TOM70_YEASTTOM70genetic
27708008
ADE_YEASTAAH1genetic
27708008
YNO4_YEASTYNL144Cgenetic
27708008
COQ2_YEASTCOQ2genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
GSHB_YEASTGSH2genetic
27708008
MSN1_YEASTMSN1genetic
27708008
2A5D_YEASTRTS1genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
RSB1_YEASTRSB1genetic
27708008
MNE1_YEASTMNE1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
PMA2_YEASTPMA2genetic
27708008
LGE1_YEASTLGE1genetic
27708008
KA120_YEASTKAP120genetic
27708008
ISU1_YEASTISU1genetic
27708008
KES1_YEASTKES1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
THP3_YEASTTHP3genetic
27708008
BRR1_YEASTBRR1genetic
27708008
MSS18_YEASTMSS18genetic
27708008
QCR2_YEASTQCR2genetic
27708008
ATG18_YEASTATG18physical
27498190
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-1113, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASSSPECTROMETRY.

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