| UniProt ID | TOM70_YEAST | |
|---|---|---|
| UniProt AC | P07213 | |
| Protein Name | Mitochondrial import receptor subunit TOM70 | |
| Gene Name | TOM70 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 617 | |
| Subcellular Localization |
Mitochondrion outer membrane Single-pass membrane protein . |
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| Protein Description | Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.. | |
| Protein Sequence | MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAISLEHTGIFKFLKNDPLGAHEDIKKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKIQETLAKLREQGLM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MKSFITRNKT -----CCCCCCCCHH | 22.15 | 23749301 | |
| 65 | Phosphorylation | ETEGAKKSTAPSNPP HCHHCCCCCCCCCCC | 29.15 | 28889911 | |
| 66 | Phosphorylation | TEGAKKSTAPSNPPI CHHCCCCCCCCCCCC | 52.01 | 21551504 | |
| 69 | Phosphorylation | AKKSTAPSNPPIYPV CCCCCCCCCCCCCCC | 60.55 | 29136822 | |
| 74 | Phosphorylation | APSNPPIYPVSSNGE CCCCCCCCCCCCCCC | 11.89 | 22369663 | |
| 77 | Phosphorylation | NPPIYPVSSNGEPDF CCCCCCCCCCCCCCC | 17.37 | 22369663 | |
| 78 | Phosphorylation | PPIYPVSSNGEPDFS CCCCCCCCCCCCCCC | 49.43 | 22369663 | |
| 85 | Phosphorylation | SNGEPDFSNKANFTA CCCCCCCCCCCCCCH | 44.81 | 22369663 | |
| 87 | Ubiquitination | GEPDFSNKANFTAEE CCCCCCCCCCCCHHH | 43.43 | 24961812 | |
| 95 | Acetylation | ANFTAEEKDKYALAL CCCCHHHHHHHEEEE | 51.53 | 24489116 | |
| 97 | Acetylation | FTAEEKDKYALALKD CCHHHHHHHEEEECC | 43.41 | 24489116 | |
| 98 | Phosphorylation | TAEEKDKYALALKDK CHHHHHHHEEEECCC | 19.58 | 21440633 | |
| 103 | Succinylation | DKYALALKDKGNQFF HHHEEEECCCCCHHH | 52.35 | 23954790 | |
| 103 | Acetylation | DKYALALKDKGNQFF HHHEEEECCCCCHHH | 52.35 | 24489116 | |
| 144 | Phosphorylation | NLSACYVSVGDLKKV CCEEEEEEHHHHHHH | 8.23 | 27214570 | |
| 156 | Phosphorylation | KKVVEMSTKALELKP HHHHHHCHHHHHCCC | 21.01 | 21440633 | |
| 162 | Acetylation | STKALELKPDYSKVL CHHHHHCCCCHHHHH | 26.85 | 24489116 | |
| 167 | Acetylation | ELKPDYSKVLLRRAS HCCCCHHHHHHHHCC | 30.58 | 24489116 | |
| 167 | Ubiquitination | ELKPDYSKVLLRRAS HCCCCHHHHHHHHCC | 30.58 | 23749301 | |
| 174 | Phosphorylation | KVLLRRASANEGLGK HHHHHHCCCCCCCHH | 29.80 | 25521595 | |
| 181 | Ubiquitination | SANEGLGKFADAMFD CCCCCCHHHHHHHHH | 42.28 | 24961812 | |
| 213 | Ubiquitination | MLERNLNKQAMSKLK HHHHHCCHHHHHHHH | 42.47 | 23749301 | |
| 220 | Acetylation | KQAMSKLKEKFGDID HHHHHHHHHHHCCCC | 63.70 | 24489116 | |
| 222 | Acetylation | AMSKLKEKFGDIDTA HHHHHHHHHCCCCCC | 53.73 | 24489116 | |
| 228 | Phosphorylation | EKFGDIDTATATPTE HHHCCCCCCCCCCCH | 26.66 | 22369663 | |
| 230 | Phosphorylation | FGDIDTATATPTELS HCCCCCCCCCCCHHC | 32.91 | 22369663 | |
| 232 | Phosphorylation | DIDTATATPTELSTQ CCCCCCCCCCHHCCC | 26.79 | 22369663 | |
| 234 | Phosphorylation | DTATATPTELSTQPA CCCCCCCCHHCCCCH | 45.24 | 22369663 | |
| 237 | Phosphorylation | TATPTELSTQPAKER CCCCCHHCCCCHHHH | 20.82 | 19795423 | |
| 238 | Phosphorylation | ATPTELSTQPAKERK CCCCHHCCCCHHHHC | 51.72 | 19795423 | |
| 242 | Ubiquitination | ELSTQPAKERKDKQE HHCCCCHHHHCHHHC | 65.81 | 23749301 | |
| 242 | Acetylation | ELSTQPAKERKDKQE HHCCCCHHHHCHHHC | 65.81 | 24489116 | |
| 245 | Ubiquitination | TQPAKERKDKQENLP CCCHHHHCHHHCCCC | 71.07 | 22817900 | |
| 247 | Ubiquitination | PAKERKDKQENLPSV CHHHHCHHHCCCCCH | 63.65 | 22817900 | |
| 300 | Acetylation | RSPESYDKADESFTK HCHHHHHHHCHHHHH | 49.89 | 24489116 | |
| 307 | Acetylation | KADESFTKAARLFEE HHCHHHHHHHHHHHH | 37.73 | 24489116 | |
| 324 | Acetylation | DKNNEDEKLKEKLAI HCCCCCHHHHHHHHH | 76.74 | 24489116 | |
| 343 | Acetylation | TGIFKFLKNDPLGAH HCHHHHHHCCCCCCC | 63.54 | 24489116 | |
| 354 | Acetylation | LGAHEDIKKAIELFP CCCCHHHHHHHHHHH | 48.77 | 24489116 | |
| 388 | Acetylation | EYYNYFDKALKLDSN HHHHHHHHEECCCCC | 45.80 | 24489116 | |
| 388 | Ubiquitination | EYYNYFDKALKLDSN HHHHHHHHEECCCCC | 45.80 | 22817900 | |
| 391 | Acetylation | NYFDKALKLDSNNSS HHHHHEECCCCCCCC | 55.92 | 24489116 | |
| 391 | Ubiquitination | NYFDKALKLDSNNSS HHHHHEECCCCCCCC | 55.92 | 22817900 | |
| 418 | Acetylation | QNYDQAGKDFDKAKE ECHHHCCCCHHHHHH | 59.23 | 24489116 | |
| 422 | Acetylation | QAGKDFDKAKELDPE HCCCCHHHHHHCCHH | 62.44 | 24489116 | |
| 516 | Phosphorylation | VGKATLLTRNPTVEN CCCHHHHCCCCCHHH | 31.36 | 21440633 | |
| 520 | Phosphorylation | TLLTRNPTVENFIEA HHHCCCCCHHHHHHH | 43.96 | 21440633 | |
| 533 | Acetylation | EATNLLEKASKLDPR HHHHHHHHHHCCCCH | 58.91 | 24489116 | |
| 536 | Ubiquitination | NLLEKASKLDPRSEQ HHHHHHHCCCCHHHH | 62.86 | 23749301 | |
| 578 | Acetylation | LARTMEEKLQAITFA HHHHHHHHHHHHHHH | 32.37 | 24489116 | |
| 589 | Acetylation | ITFAEAAKVQQRIRS HHHHHHHHHHHHHHC | 47.85 | 24489116 | |
| 596 | Phosphorylation | KVQQRIRSDPVLAKK HHHHHHHCCHHHHHH | 43.84 | 23749301 | |
| 610 | Ubiquitination | KIQETLAKLREQGLM HHHHHHHHHHHCCCC | 51.71 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOM70_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOM70_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOM70_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78; SER-174; THR-232 ANDTHR-234, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND MASSSPECTROMETRY. | |
