PKH3_YEAST - dbPTM
PKH3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKH3_YEAST
UniProt AC Q03306
Protein Name Serine/threonine-protein kinase PKH3
Gene Name PKH3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 898
Subcellular Localization
Protein Description Serine/threonine-protein kinase which may phosphorylate the same targets substrates as PKH1 and PKH2, 2 upstream activators of PKC1..
Protein Sequence MTSRKRSPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENELKTFEKIVALDYPWGPNNRINNSTSPINPLVINLVQKILVIEVNERISLEQIKRHPYFSKVDWNDKIKIWRGIWQSQGQSLQQTTLGLPNIPQNILPTRQLHVIDTPARSIQITKQKRKKPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSTTPAVTAPNDTNVLTNTAAHSTANIALPPNSQSNQVKRAQLVAPNRIPPKVPVINDNVRNKSIPRTKPNVPPLQTSSIPQKLSTSSASSALSAPSTEIRNQDLTHTLDGRNSIDIHVLKQDYVFIYGIPYEHEGPAMSLNSYNKIDNDLITSLVAQHKEELKNSESFLQVLTLKKSGMLSYKNTVMEGNDDQENKEHQMANIEDTDLSMYDFEFNELTRKGFLILEKYKNRIWFISLPSYSTLSKIPFNAVKSSTINNNENWVDCFFRARQLLEEKQILDKISNVSFDSKASSEPSSPPPISRKERPLSIGNNVTTLSYTAKNGSQNNAPQNDNVGEEKPFRIPSSTKDRPGANSTPSSRHPRVLSSNNAGETPKKMNGRLPNSAPSTNTYTNGSVPAFNHRPSTNVGNNKHNILTSKKQGSSVFSPSSSTTKPQIKTTGYRQPTPSPPLPQMEFPTTREKYSAPSNMVISSSRYEVLHTLNNSQTNFDREIASRGASAAFRSLQKSKKKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56PhosphorylationIKEAKVKYVTIEKNT
HEEEEEEEEEECHHH		13.0519795423
58PhosphorylationEAKVKYVTIEKNTMN
EEEEEEEEECHHHHH		21.9619823750
453PhosphorylationRNKSIPRTKPNVPPL
CCCCCCCCCCCCCCC		45.5621440633
472PhosphorylationIPQKLSTSSASSALS
CCCCCCCCCHHHHHC		22.1128889911
476PhosphorylationLSTSSASSALSAPST
CCCCCHHHHHCCCCC		32.7127017623
479PhosphorylationSSASSALSAPSTEIR
CCHHHHHCCCCCCHH		37.5428889911
499PhosphorylationHTLDGRNSIDIHVLK
CCCCCCCCEEEEEEC		21.9328889911
592PhosphorylationQMANIEDTDLSMYDF
HHCCCCCCCCCEEEE		26.5019779198
595PhosphorylationNIEDTDLSMYDFEFN
CCCCCCCCEEEEEHH		20.3619823750
597PhosphorylationEDTDLSMYDFEFNEL
CCCCCCEEEEEHHHH		17.6919823750
605PhosphorylationDFEFNELTRKGFLIL
EEEHHHHHHCCEEEE		24.9319823750
673PhosphorylationLDKISNVSFDSKASS
HHHHHHCCCCCCCCC		27.8222369663
676PhosphorylationISNVSFDSKASSEPS
HHHCCCCCCCCCCCC		28.2722369663
679PhosphorylationVSFDSKASSEPSSPP
CCCCCCCCCCCCCCC		38.6819823750
680PhosphorylationSFDSKASSEPSSPPP
CCCCCCCCCCCCCCC		59.3925521595
683PhosphorylationSKASSEPSSPPPISR
CCCCCCCCCCCCCCC		51.9619823750
684PhosphorylationKASSEPSSPPPISRK
CCCCCCCCCCCCCCC		52.7425521595
689PhosphorylationPSSPPPISRKERPLS
CCCCCCCCCCCCCCC		42.9719823750
696PhosphorylationSRKERPLSIGNNVTT
CCCCCCCCCCCCEEE		31.0022369663
702PhosphorylationLSIGNNVTTLSYTAK
CCCCCCEEEEEEEEC		24.9222369663
703PhosphorylationSIGNNVTTLSYTAKN
CCCCCEEEEEEEECC		14.9322369663
705PhosphorylationGNNVTTLSYTAKNGS
CCCEEEEEEEECCCC		20.5322369663
706PhosphorylationNNVTTLSYTAKNGSQ
CCEEEEEEEECCCCC		17.5222369663
707PhosphorylationNVTTLSYTAKNGSQN
CEEEEEEEECCCCCC		27.9922369663
745PhosphorylationPGANSTPSSRHPRVL
CCCCCCCCCCCCCCC		39.8421551504
753PhosphorylationSRHPRVLSSNNAGET
CCCCCCCCCCCCCCC		28.3222369663
754PhosphorylationRHPRVLSSNNAGETP
CCCCCCCCCCCCCCC		29.9121440633
760PhosphorylationSSNNAGETPKKMNGR
CCCCCCCCCCCCCCC		39.2223749301
809PhosphorylationLTSKKQGSSVFSPSS
ECCCCCCCCCCCCCC		22.3421440633
825PhosphorylationTTKPQIKTTGYRQPT
CCCCCEECCCCCCCC		27.3822369663
826PhosphorylationTKPQIKTTGYRQPTP
CCCCEECCCCCCCCC		27.4922369663
828PhosphorylationPQIKTTGYRQPTPSP
CCEECCCCCCCCCCC		12.1821440633
832PhosphorylationTTGYRQPTPSPPLPQ
CCCCCCCCCCCCCCC		28.2322369663
834PhosphorylationGYRQPTPSPPLPQME
CCCCCCCCCCCCCCC		41.4422369663
844PhosphorylationLPQMEFPTTREKYSA
CCCCCCCCCHHHCCC		43.7521440633
845PhosphorylationPQMEFPTTREKYSAP
CCCCCCCCHHHCCCC		36.7522369663
849PhosphorylationFPTTREKYSAPSNMV
CCCCHHHCCCCCCEE		12.8128132839
867PhosphorylationSRYEVLHTLNNSQTN
HHHHHHHHHCCCCCC		27.3330377154
871PhosphorylationVLHTLNNSQTNFDRE
HHHHHCCCCCCHHHH		36.9923749301
873PhosphorylationHTLNNSQTNFDREIA
HHHCCCCCCHHHHHH		37.3619779198
885PhosphorylationEIASRGASAAFRSLQ
HHHHHHHHHHHHHHH		23.9730377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKH3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKH3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKH3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ECM22_YEASTECM22physical
16319894
YMD7_YEASTYML037Cphysical
16319894
IF4E_YEASTCDC33physical
16319894
SIP4_YEASTSIP4physical
16319894
CSL4_YEASTCSL4physical
16319894
RBD2_YEASTRBD2physical
16319894
STE50_YEASTSTE50genetic
19269370
KHSE_YEASTTHR1genetic
19269370
SCH9_YEASTSCH9genetic
19269370
STE50_YEASTSTE50genetic
20093466
AVT1_YEASTAVT1genetic
20093466
HOC1_YEASTHOC1genetic
20093466
VRP1_YEASTVRP1genetic
20093466
TOM70_YEASTTOM70genetic
20093466
2A5D_YEASTRTS1genetic
20093466
BCK1_YEASTBCK1physical
20489023
BFR2_YEASTBFR2physical
20489023
CIC1_YEASTCIC1physical
20489023
ERB1_YEASTERB1physical
20489023
MAK5_YEASTMAK5physical
20489023
C1TM_YEASTMIS1physical
20489023
MRM1_YEASTMRM1physical
20489023
NOG1_YEASTNOG1physical
20489023
NOP12_YEASTNOP12physical
20489023
PAM1_YEASTPAM1physical
20489023
PWP1_YEASTPWP1physical
20489023
RPF1_YEASTRPF1physical
20489023
YE12B_YEASTYER160Cphysical
20489023
RV161_YEASTRVS161genetic
20526336
TOR2_YEASTTOR2genetic
20526336
ARP8_YEASTARP8physical
21460040
TCPZ_YEASTCCT6physical
21460040
CSM3_YEASTCSM3physical
21460040
ATG19_YEASTATG19physical
21460040
DRS1_YEASTDRS1physical
21460040
SYFB_YEASTFRS1physical
21460040
BUD27_YEASTBUD27physical
21460040
MFT1_YEASTMFT1physical
21460040
OCA1_YEASTOCA1physical
21460040
PFD3_YEASTPAC10physical
21460040
KPR1_YEASTPRS1physical
21460040
RIM4_YEASTRIM4physical
21460040
RIR4_YEASTRNR4physical
21460040
RTR1_YEASTRTR1physical
21460040
UBX1_YEASTSHP1physical
21460040
ACL4_YEASTYDR161Wphysical
21460040
YG1B_YEASTYGR017Wphysical
21460040
YG1D_YEASTYGR021Wphysical
21460040
DPH4_YEASTJJJ3physical
21460040
YJ9S_YEASTYJR154Wphysical
21460040
SWI5_YEASTSWI5genetic
21127252
PPZ2_YEASTPPZ2genetic
21127252
ARO80_YEASTARO80genetic
21127252
AP2_YEASTCAD1genetic
21127252
UME6_YEASTUME6genetic
21127252
TOM70_YEASTTOM70genetic
22282571
STE50_YEASTSTE50genetic
22282571
AVT1_YEASTAVT1genetic
22282571
HOC1_YEASTHOC1genetic
22282571
2A5D_YEASTRTS1genetic
22282571
VRP1_YEASTVRP1genetic
22282571
CDC4_YEASTCDC4genetic
27708008
MTW1_YEASTMTW1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
CDC1_YEASTCDC1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
RSP5_YEASTRSP5genetic
27708008
STT3_YEASTSTT3genetic
27708008
SLD3_YEASTSLD3genetic
27708008
MET30_YEASTMET30genetic
27708008
KRE9_YEASTKRE9genetic
27708008
CDC11_YEASTCDC11genetic
27708008
HYM1_YEASTHYM1genetic
27708008
SEC13_YEASTSEC13genetic
27708008
MCM1_YEASTMCM1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
KRE5_YEASTKRE5genetic
27708008
GPI2_YEASTGPI2genetic
27708008
SEC62_YEASTSEC62genetic
27708008
NAB3_YEASTNAB3genetic
27708008
STE50_YEASTSTE50genetic
27708008
DS1P1_YEASTLCB3genetic
27708008
HOC1_YEASTHOC1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
OYE3_YEASTOYE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKH3_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472; SER-479; SER-673;SER-680; SER-683; SER-684; SER-696 AND SER-834, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory