AP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2_YEAST
• UniProt AC: P24813
• Protein Name: AP-1-like transcription factor YAP2 {ECO:0000305}
• Gene Name: CAD1 {ECO:0000303|PubMed:8360174}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 409
• Subcellular Localization: Cytoplasm . Nucleus . Oxidized CAD1/YAP2 is found predominantly in the nucleus, while reduced CAD1/YAP2 is continuously exported to the cytoplasm by CRM1/exportin 1.
• Protein Description: Transcription activator involved in oxidative stress response and cadmium resistance. Regulates the transcription of genes overrepresented for the function of stabilizing proteins including the inducible Hsp90-family protein HSP82. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Activation by alkyl hydroperoxides or cadmium induces nuclear accumulation and as a result CAD1/YAP2 transcriptional activity..
• Protein Sequence: MGNILRKGQQIYLAGDMKKQMLLNKDGTPKRKVGRPGRKRIDSEAKSRRTAQNRAAQRAFRDRKEAKMKSLQERVELLEQKDAQNKTTTDFLLCSLKSLLSEITKYRAKNSDDERILAFLDDLQEQQKRENEKGTSTAVSKAAKELPSPNSDENMTVNTSIEVQPHTQENEKVMWNIGSWNAPSLTNSWDSPPGNRTGAVTIGDESINGSEMPDFSLDLVSNDRQTGLEALDYDIHNYFPQHSERLTAEKIDTSACQCEIDQKYLPYETEDDTLFPSVLPLAVGSQCNNICNRKCIGTKPCSNKEIKCDLITSHLLNQKSLASVLPVAASHTKTIRTQSEAIEHISSAISNGKASCYHILEEISSLPKYSSLDIDDLCSELIIKAKCTDDCKIVVKARDLQSALVRQLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Acetylation	SLLSEITKYRAKNSD HHHHHHHHHHHCCCC		24489116
148	Phosphorylation	KAAKELPSPNSDENM HHHHCCCCCCCCCCC		19795423
151	Phosphorylation	KELPSPNSDENMTVN HCCCCCCCCCCCEEE		21440633
156	Phosphorylation	PNSDENMTVNTSIEV CCCCCCCEEEEEEEE		19795423
159	Phosphorylation	DENMTVNTSIEVQPH CCCCEEEEEEEECCC		19795423
160	Phosphorylation	ENMTVNTSIEVQPHT CCCEEEEEEEECCCC		24961812
191	Phosphorylation	SLTNSWDSPPGNRTG CCCCCCCCCCCCCCC		27738172
250	Ubiquitination	SERLTAEKIDTSACQ HHCCCHHHCCCCCCC		23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCK1_YEAST	RCK1	physical	15341652
AHP1_YEAST	AHP1	physical	20145245
UGA3_YEAST	UGA3	genetic	20831804
FZF1_YEAST	FZF1	genetic	20831804
ARP8_YEAST	ARP8	genetic	20959818
EAF5_YEAST	EAF5	genetic	20959818
IES4_YEAST	IES4	genetic	20959818
YPT6_YEAST	YPT6	genetic	20959818
AP2_YEAST	CAD1	physical	23661758
RCK1_YEAST	RCK1	genetic	26296316
GPR1_YEAST	GPR1	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
SNF5_YEAST	SNF5	genetic	27708008
YJB6_YEAST	YJL016W	genetic	27708008
CUL8_YEAST	RTT101	genetic	27708008
PBS2_YEAST	PBS2	genetic	27708008
RS21B_YEAST	RPS21B	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
MOG1_YEAST	MOG1	genetic	27708008
PYRE_YEAST	URA5	genetic	27708008
PACC_YEAST	RIM101	genetic	28826004

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.