ARO80_YEAST - dbPTM
ARO80_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARO80_YEAST
UniProt AC Q04052
Protein Name Transcriptional activator ARO80
Gene Name ARO80
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 950
Subcellular Localization Nucleus .
Protein Description Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10..
Protein Sequence MSAKKRPSGNAAFELPKRRRTYQACISCRSRKVKCDLGPVDNPHDPPCARCKRELKKCIFSSNKGTSNDLPPNSINAISLPSLGKSKQEIQNDSTSPILSDVPLSRKGISSEKSFKSEGMKWKLELSSMQNALEFLAQAAGTVAKEGAKEIIKEKSTTPKPLKSSLDATNKSATDEGLKRLSKSDSTNTLYENTADMLNHTLNTNRKTSQLMEEIGKVRPPPTRKIDDFDYIGPDSLLTKEEAIELIEAFFLTMHPFFPNIPLQLHDPKELAEYPILFCAILTVSARYHPFDTLGLDNGEDGMRHIEVHDKLWVYCQKLISQTIWAEASTRSIGTVLAFIIFTEWNPRSIHYKWSDYANDPELNNVNARGSKNISTRKDEEGLTGVGAIRRSDRMSWMLTGSAVRLAQDMGFIENSSKVFIVTHISETTSAMNMNQRSLLAESFSVLNLNLGKIENDGNESNEDYLGNEKFYLNEILPDEESKLRWKRVFENSENDHDNEKNFLTDWEREFLNDEYVLYYSNKKDDTNLAQNHIPPFPLRFSFAQRAKIEIIRILSIAYETIYCEKNKRKLATTDQRHNLSVLSVFSPLIEGWLSNYRELLVPLSDVPFSLADRKNKKQIFDNIDRINGESIITDFNYCQLYIFSLALQVDGKTSRLNMNEIVTSARYVELAYRSAKEILSSAKRVSRQGMLKYMPVRWVIRIIRSIAFIVKCYLTLTGSELATNPDARNILKLSAISVDETFDIIRDTAVTLKEATPDELHLCQRYAAILMYLCTEMKLRKKSYLERPPLLRDGTTPLESNRESSLEGQDLTKKPIFSKRIGYNKTETTFEPSERPLTEEINSNSQNSNDTSSKGIVDPFVEQNNDITTALLNNELFQGPSLSDEVTDWFGASEDIGLEFVEPWTELIEQRYMQCGDGDNNNFENLYNLFVNSNNINNDINNSRPITRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
95PhosphorylationQEIQNDSTSPILSDV
HHHCCCCCCCCHHCC		41.1923749301
96PhosphorylationEIQNDSTSPILSDVP
HHCCCCCCCCHHCCC		17.5617330950
100PhosphorylationDSTSPILSDVPLSRK
CCCCCCHHCCCCCCC		36.9621440633
121AcetylationSFKSEGMKWKLELSS
HHHCCCCCCCHHHHH		52.6225381059
142PhosphorylationFLAQAAGTVAKEGAK
HHHHHHHHHHHHHHH		16.7428889911
156PhosphorylationKEIIKEKSTTPKPLK
HHHHHCCCCCCCCCC		38.3119823750
157PhosphorylationEIIKEKSTTPKPLKS
HHHHCCCCCCCCCCH		59.1819795423
158PhosphorylationIIKEKSTTPKPLKSS
HHHCCCCCCCCCCHH		36.0823749301
179AcetylationSATDEGLKRLSKSDS
CCCHHHHHHHCCCCC		63.2525381059
184PhosphorylationGLKRLSKSDSTNTLY
HHHHHCCCCCCCHHH		33.1622369663
186PhosphorylationKRLSKSDSTNTLYEN
HHHCCCCCCCHHHHH		30.5521440633
187PhosphorylationRLSKSDSTNTLYENT
HHCCCCCCCHHHHHH		36.8922369663
189PhosphorylationSKSDSTNTLYENTAD
CCCCCCCHHHHHHHH		30.7022369663
191PhosphorylationSDSTNTLYENTADML
CCCCCHHHHHHHHHH		12.7022369663
194PhosphorylationTNTLYENTADMLNHT
CCHHHHHHHHHHHHH		16.4622369663
201PhosphorylationTADMLNHTLNTNRKT
HHHHHHHHHCCCHHH		22.1922369663
204PhosphorylationMLNHTLNTNRKTSQL
HHHHHHCCCHHHHHH		39.2422369663
687PhosphorylationLSSAKRVSRQGMLKY
HHHCCHHHCCCCHHH		23.9519795423
694PhosphorylationSRQGMLKYMPVRWVI
HCCCCHHHCCHHHHH		11.5919795423
706PhosphorylationWVIRIIRSIAFIVKC
HHHHHHHHHHHHHHH		14.0919795423
796PhosphorylationPPLLRDGTTPLESNR
CCCCCCCCCCCCCCC		29.5428889911
797PhosphorylationPLLRDGTTPLESNRE
CCCCCCCCCCCCCCC		31.2628889911
801PhosphorylationDGTTPLESNRESSLE
CCCCCCCCCCCCCCC		49.2022369663
805PhosphorylationPLESNRESSLEGQDL
CCCCCCCCCCCCCCC		36.6722369663
806PhosphorylationLESNRESSLEGQDLT
CCCCCCCCCCCCCCC		26.2022369663
813PhosphorylationSLEGQDLTKKPIFSK
CCCCCCCCCCCCCEE		45.3622369663
849PhosphorylationINSNSQNSNDTSSKG
HHCCCCCCCCCCCCC		28.5730377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARO80_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARO80_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARO80_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTD1_YEASTMTD1physical
18467557
RRP6_YEASTRRP6genetic
20959818
FLO8_YEASTFLO8genetic
20959818
SPT3_YEASTSPT3genetic
20959818
ARP8_YEASTARP8genetic
20959818
UBP8_YEASTUBP8genetic
20959818
SGF73_YEASTSGF73genetic
20959818
CTH2_YEASTTIS11genetic
20959818
CTF18_YEASTCTF18genetic
20959818
EAF7_YEASTEAF7genetic
20959818
MRM2_YEASTMRM2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ENV10_YEASTENV10genetic
27708008
SHE1_YEASTSHE1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
PAA1_YEASTPAA1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
MTC3_YEASTMTC3genetic
27708008
AP3B_YEASTAPL6genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SST2_YEASTSST2genetic
27708008
TOP1_YEASTTOP1genetic
27708008
DCAM_YEASTSPE2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARO80_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-158 AND SER-806, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-805, AND MASSSPECTROMETRY.

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