AP3B_YEAST - dbPTM
AP3B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP3B_YEAST
UniProt AC P46682
Protein Name AP-3 complex subunit beta
Gene Name APL6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 809
Subcellular Localization Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein Description Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole..
Protein Sequence MVDSIHRIASALDTAKVITREAAAVATSKLGESSYTYYSQNINPQQLVTLLNSRNSREVRDAMKRIISIMASDDDSIDVQLYFADVVKNITTNDTKVKRLIHLYLLRFAENDPNLTLLSINSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILHTVKKLVTDPSAMVRGEVALAIIKLYRAGKNDYHEELLDILKELMADTDPKVISCAVLAYKECYADHLELLHGHFRRYCRIIKQLDSWSQSYLIELLIKYCKQYLPKPTVVDKSSEGSPRSCPLPDKYNEIEYPSYEVVNDPDLDLFLQSLNCLIYSSNPTVILSCCNALYQLASPLQMKNTKFIEALVRTVTMTENQGNKEMLLQAIHFLSILDQTLFLPYTKKFYVFPKDPIVASIWKIQILSTLINESNVKEIFKELKYYVASAHFPENVVIMAVKSLSRCGQLSTSWESHVMKWLIDHMESHNLSASVLDAYVNVIRMLVQKNPTKHLRIIFKLADLLTVQTSLADNARAGIVWLFGEIASIEFKICPDVLRRLIQNFSNEGPETRCQILVLSAKLLSYDIDNFKQAQVTGSEENNQNPPYYDFSGSRISQMYNAVLYLAKYDDEFDIRDRARMISSLFDSGKYEIVSLLLQAPKPTARSDDFIVSARLETHTPEIKEFFRMLPWNTEITEVGETGNDIREGAELKDYNKYKKSFSSQSFITNNSARSFTSSSNAKLTGINDGDSNSISGKGNVNTFTSQNGKKYRLQSLDEFFSDIPERKSKPRKIIKVVEESSDEDEDESEESSDDDEYSDSSLGTSSSGTSSSHLEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVDSIHRIASA
----CCHHHHHHHHH		14.6422369663
10PhosphorylationDSIHRIASALDTAKV
HHHHHHHHHHHHHHH		27.3022369663
14PhosphorylationRIASALDTAKVITRE
HHHHHHHHHHHHHHH		29.2722369663
27PhosphorylationREAAAVATSKLGESS
HHHHHHHHCCCCCCC		21.5730377154
128PhosphorylationNSLQKSLSDSNSELR
HHHHHHCCCCCHHHH		46.1927017623
130PhosphorylationLQKSLSDSNSELRCF
HHHHCCCCCHHHHHH		38.5927017623
132PhosphorylationKSLSDSNSELRCFAL
HHCCCCCHHHHHHHH		41.7927017623
242PhosphorylationRIIKQLDSWSQSYLI
HHHHHHHCCCHHHHH		36.9028889911
244PhosphorylationIKQLDSWSQSYLIEL
HHHHHCCCHHHHHHH		17.1328889911
246PhosphorylationQLDSWSQSYLIELLI
HHHCCCHHHHHHHHH		19.1821082442
259PhosphorylationLIKYCKQYLPKPTVV
HHHHHHHHCCCCEEE		15.5128889911
269PhosphorylationKPTVVDKSSEGSPRS
CCEEECCCCCCCCCC		29.2028889911
270PhosphorylationPTVVDKSSEGSPRSC
CEEECCCCCCCCCCC		52.2820377248
273PhosphorylationVDKSSEGSPRSCPLP
ECCCCCCCCCCCCCC		17.0620377248
406PhosphorylationLSTLINESNVKEIFK
HHHHCCCCCHHHHHH		42.3027017623
639PhosphorylationAPKPTARSDDFIVSA
CCCCCCCCCCEEEEE		38.7830377154
656AcetylationETHTPEIKEFFRMLP
ECCCHHHHHHHHHCC		46.9724489116
693PhosphorylationDYNKYKKSFSSQSFI
CHHHHCCCCCCCCCC		26.6422369663
695PhosphorylationNKYKKSFSSQSFITN
HHHCCCCCCCCCCCC		34.2622369663
696PhosphorylationKYKKSFSSQSFITNN
HHCCCCCCCCCCCCC		28.0322369663
698PhosphorylationKKSFSSQSFITNNSA
CCCCCCCCCCCCCCC		22.1422369663
701PhosphorylationFSSQSFITNNSARSF
CCCCCCCCCCCCCCE		26.7421551504
704PhosphorylationQSFITNNSARSFTSS
CCCCCCCCCCCEECC		27.4222369663
707PhosphorylationITNNSARSFTSSSNA
CCCCCCCCEECCCCC		32.3721440633
709PhosphorylationNNSARSFTSSSNAKL
CCCCCCEECCCCCEE		29.0121440633
710PhosphorylationNSARSFTSSSNAKLT
CCCCCEECCCCCEEC		29.7421440633
711PhosphorylationSARSFTSSSNAKLTG
CCCCEECCCCCEECC		25.2621551504
712PhosphorylationARSFTSSSNAKLTGI
CCCEECCCCCEECCC		40.3421440633
715UbiquitinationFTSSSNAKLTGINDG
EECCCCCEECCCCCC		51.3223749301
717PhosphorylationSSSNAKLTGINDGDS
CCCCCEECCCCCCCC		35.0022890988
724PhosphorylationTGINDGDSNSISGKG
CCCCCCCCCCCCCCC		37.7019823750
726PhosphorylationINDGDSNSISGKGNV
CCCCCCCCCCCCCCC		23.2925521595
728PhosphorylationDGDSNSISGKGNVNT
CCCCCCCCCCCCCEE		33.9822890988
730UbiquitinationDSNSISGKGNVNTFT
CCCCCCCCCCCEEEE		40.2923749301
737PhosphorylationKGNVNTFTSQNGKKY
CCCCEEEECCCCCEE		27.6230377154
744PhosphorylationTSQNGKKYRLQSLDE
ECCCCCEEEECCHHH		21.7521440633
748PhosphorylationGKKYRLQSLDEFFSD
CCEEEECCHHHHHHC		42.2428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP3B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP3B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP3B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP3D_YEASTAPL5physical
11805826
AP3M_YEASTAPM3physical
11805826
ENO2_YEASTENO2physical
11805826
AP1B1_YEASTAPL2physical
10564262
AP3S_YEASTAPS3physical
16554755
CORO_YEASTCRN1physical
16554755
AP3D_YEASTAPL5physical
16554755
AP3D_YEASTAPL5physical
16429126
AP3M_YEASTAPM3physical
16429126
ENO2_YEASTENO2physical
16429126
SWA2_YEASTSWA2genetic
16269340
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
ARL1_YEASTARL1genetic
16269340
SYS1_YEASTSYS1genetic
16269340
COG8_YEASTCOG8genetic
16269340
COG6_YEASTCOG6genetic
16269340
COG5_YEASTCOG5genetic
16269340
PKR1_YEASTPKR1genetic
16269340
TLG2_YEASTTLG2genetic
16269340
GYP1_YEASTGYP1genetic
16269340
ERG4_YEASTERG4genetic
16269340
ARF1_YEASTARF1genetic
16269340
ARL3_YEASTARL3genetic
16269340
ALG10_YEASTDIE2genetic
16269340
OST3_YEASTOST3genetic
16269340
STV1_YEASTSTV1genetic
16269340
ALG6_YEASTALG6genetic
16269340
ALG5_YEASTALG5genetic
16269340
CUE5_YEASTCUE5genetic
16269340
ERG6_YEASTERG6genetic
16269340
BFR1_YEASTBFR1genetic
16269340
AP3B_YEASTAPL6physical
18467557
AP3D_YEASTAPL5physical
18467557
CHS5_YEASTCHS5physical
18467557
HUA2_YEASTHUA2physical
18719252
RDR1_YEASTRDR1physical
18719252
ATG17_YEASTATG17physical
18719252
ADA2_YEASTADA2physical
18719252
GCR2_YEASTGCR2physical
18719252
URC2_YEASTURC2physical
18719252
AP3B_YEASTAPL6physical
22615397
VPH1_YEASTVPH1genetic
23891562
GOSR1_YEASTGOS1genetic
23891562
ARL1_YEASTARL1genetic
23891562
SYS1_YEASTSYS1genetic
23891562
ARL3_YEASTARL3genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
YPT6_YEASTYPT6genetic
23891562
COG8_YEASTCOG8genetic
23891562
COG6_YEASTCOG6genetic
23891562
RUD3_YEASTRUD3genetic
23891562
VPS10_YEASTPEP1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
VPS17_YEASTVPS17genetic
23891562
SRO7_YEASTSRO7genetic
23891562
ELO3_YEASTELO3genetic
23891562
CSG2_YEASTCSG2genetic
23891562
VPS55_YEASTVPS55genetic
23891562
PEX19_YEASTPEX19genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
MSN5_YEASTMSN5genetic
27708008
THIK_YEASTPOT1genetic
27708008
VPS55_YEASTVPS55genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
GAC1_YEASTGAC1genetic
27708008
RMI1_YEASTRMI1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
RIFK_YEASTFMN1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
SED5_YEASTSED5genetic
27708008
BET5_YEASTBET5genetic
27708008
MOT1_YEASTMOT1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
VPS10_YEASTPEP1genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
BPH1_YEASTBPH1genetic
27708008
ELO2_YEASTELO2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
MTU1_YEASTSLM3genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
RPA14_YEASTRPA14genetic
27708008
MNN10_YEASTMNN10genetic
27708008
LSM6_YEASTLSM6genetic
27708008
MSH4_YEASTMSH4genetic
27708008
CGR1_YEASTCGR1genetic
27708008
MED5_YEASTNUT1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
GCN1_YEASTGCN1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
MSC7_YEASTMSC7genetic
27708008
LRP1_YEASTLRP1genetic
27708008
ATG32_YEASTATG32genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ASF1_YEASTASF1genetic
27708008
VPS35_YEASTVPS35genetic
27708008
LDB18_YEASTLDB18genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
MSC3_YEASTMSC3genetic
27708008
ADY4_YEASTADY4genetic
27708008
ARV1_YEASTARV1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
VPS9_YEASTVPS9genetic
27708008
HXT2_YEASTHXT2genetic
27708008
RIM13_YEASTRIM13genetic
27708008
IDH1_YEASTIDH1genetic
27708008
OCA2_YEASTOCA2genetic
27708008
YNM2_YEASTYNL122Cgenetic
27708008
ATG3_YEASTATG3genetic
27708008
IZH2_YEASTIZH2genetic
27708008
MSB4_YEASTMSB4genetic
27708008
TRM11_YEASTTRM11genetic
27708008
VPS17_YEASTVPS17genetic
27708008
CHL1_YEASTCHL1genetic
27708008
SUE1_YEASTSUE1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
PSME3_HUMANPSME3physical
27107014
CEP70_HUMANCEP70physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP3B_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-695; SER-696;SER-698 AND SER-726, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-726, AND MASSSPECTROMETRY.

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