| UniProt ID | COG8_YEAST | |
|---|---|---|
| UniProt AC | Q04632 | |
| Protein Name | Conserved oligomeric Golgi complex subunit 8 | |
| Gene Name | COG8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 607 | |
| Subcellular Localization |
Golgi apparatus membrane Peripheral membrane protein. |
|
| Protein Description | Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.. | |
| Protein Sequence | MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEYQKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCDLNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | LQSNTKDYESYFSSR HHHCCCCHHHHHHCC | 14.34 | 27017623 | |
| 39 | Phosphorylation | NTKDYESYFSSRAVP CCCCHHHHHHCCCCC | 8.78 | 27017623 | |
| 41 | Phosphorylation | KDYESYFSSRAVPGS CCHHHHHHCCCCCCC | 15.64 | 27017623 | |
| 42 | Phosphorylation | DYESYFSSRAVPGSI CHHHHHHCCCCCCCC | 17.85 | 27017623 | |
| 127 | Phosphorylation | DINNESVSIDDFLED CCCCCCCCHHHHHHC | 29.58 | 19779198 | |
| 397 | Phosphorylation | EEYQKQDSVANNEED HHHHHHHHHHCCHHH | 22.19 | 30377154 | |
| 406 | Phosphorylation | ANNEEDVTENKSIED HCCHHHHCCCCCHHH | 46.27 | 24961812 | |
| 410 | Phosphorylation | EDVTENKSIEDVQEE HHHCCCCCHHHHHHH | 42.67 | 22369663 | |
| 433 | Phosphorylation | DDGAERKTENEIENE CCCCCCCHHHHHCHH | 50.71 | 28889911 | |
| 477 | Phosphorylation | EINKVEVTPEEPSKS HHHCCCCCCCCCCCC | 16.10 | 29136822 | |
| 502 | Phosphorylation | EINKVEVTPEEPSKK HHHCCCCCCCCCCHH | 16.10 | 29136822 | |
| 578 | Ubiquitination | YHHLFLKKINDTSLF CCCEEEECCCCCCCC | 49.22 | 24961812 | |
| 602 | Phosphorylation | DKRAELASKYIYS-- HHHHHHHHHHHCC-- | 38.32 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COG8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COG8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COG8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, AND MASSSPECTROMETRY. | |
