| UniProt ID | PMT4_YEAST | |
|---|---|---|
| UniProt AC | P46971 | |
| Protein Name | Dolichyl-phosphate-mannose--protein mannosyltransferase 4 | |
| Gene Name | PMT4 {ECO:0000303|PubMed:8585318} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 762 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a homodimeric complex to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Specifically acts on secretory proteins with an ER-luminally oriented Ser/Thr-rich region flanked by a membrane anchor such as FUS1, AXL2, GAS1, KEX2, MID2, WSC1, WSC2, OPY2, PRM5, RAX2, or YNL176.. | |
| Protein Sequence | MSVPKKRNHGKLPPSTKDVDDPSLKYTKAAPKCEQVAEHWLLQPLPEPESRYSFWVTIVTLLAFAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFFDVHPPFAKMMIAFIGWLCGYDGSFKFDEIGYSYETHPAPYIAYRSFNAILGTLTVPIMFNTLKELNFRAITCAFASLLVAIDTAHVTETRLILLDAILIISIAATMYCYVRFYKCQLRQPFTWSWYIWLHATGLSLSFVISTKYVGVMTYSAIGFAAVVNLWQLLDIKAGLSLRQFMRHFSKRLNGLVLIPFVIYLFWFWVHFTVLNTSGPGDAFMSAEFQETLKDSPLSVDSKTVNYFDIITIKHQDTDAFLHSHLARYPQRYEDGRISSAGQQVTGYTHPDFNNQWEVLPPHGSDVGKGQAVLLNQHIRLRHVATDTYLLAHDVASPFYPTNEEITTVTLEEGDGELYPETLFAFQPLKKSDEGHVLKSKTVSFRLFHVDTSVALWTHNDELLPDWGFQQQEINGNKKVIDPSNNWVVDEIVNLDEVRKVYIPKVVKPLPFLKKWIETQKSMFEHNNKLSSEHPFASEPYSWPGSLSGVSFWTNGDEKKQIYFIGNIIGWWFQVISLAVFVGIIVADLITRHRGYYALNKMTREKLYGPLMFFFVSWCCHYFPFFLMARQKFLHHYLPAHLIACLFSGALWEVIFSDCKSLDLEKDEDISGASYERNPKVYVKPYTVFLVCVSCAVAWFFVYFSPLVYGDVSLSPSEVVSREWFDIELNFSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MSVPKKRNHGKLP --CCCCCCCCCCCCC | 52.98 | 25381059 | |
| 17 | Ubiquitination | GKLPPSTKDVDDPSL CCCCCCCCCCCCCCC | 61.15 | 23749301 | |
| 17 | Acetylation | GKLPPSTKDVDDPSL CCCCCCCCCCCCCCC | 61.15 | 24489116 | |
| 25 | Ubiquitination | DVDDPSLKYTKAAPK CCCCCCCCCCCCCCC | 56.03 | 23749301 | |
| 25 | Acetylation | DVDDPSLKYTKAAPK CCCCCCCCCCCCCCC | 56.03 | 24489116 | |
| 343 | Ubiquitination | YFDIITIKHQDTDAF EEEEEEEEECCCHHH | 26.94 | 17644757 | |
| 398 | Ubiquitination | PHGSDVGKGQAVLLN CCCCCCCCCCEEEEC | 47.93 | 17644757 | |
| 508 | Ubiquitination | QEINGNKKVIDPSNN EEECCCCCEECCCCC | 48.71 | 17644757 | |
| 529 | Ubiquitination | VNLDEVRKVYIPKVV CCHHHHHEEECCCCC | 44.56 | 17644757 | |
| 534 | Acetylation | VRKVYIPKVVKPLPF HHEEECCCCCCCCHH | 50.53 | 24489116 | |
| 550 | Acetylation | KKWIETQKSMFEHNN HHHHHHHHHHHHCCC | 51.84 | 24489116 | |
| 695 | Acetylation | CKSLDLEKDEDISGA CCCCCCCCCCCCCCC | 73.96 | 24489116 | |
| 700 | Phosphorylation | LEKDEDISGASYERN CCCCCCCCCCCCCCC | 40.40 | 26447709 | |
| 703 | Phosphorylation | DEDISGASYERNPKV CCCCCCCCCCCCCCE | 30.93 | 26447709 | |
| 704 | Phosphorylation | EDISGASYERNPKVY CCCCCCCCCCCCCEE | 20.55 | 26447709 | |
| 759 | N-linked_Glycosylation | EWFDIELNFSK---- EEEEEEEECCC---- | 26.76 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PMT4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PMT4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PMT4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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