STE5_YEAST - dbPTM
STE5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE5_YEAST
UniProt AC P32917
Protein Name Protein STE5
Gene Name STE5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 917
Subcellular Localization Cytoplasm.
Protein Description Component of the pheromone signal transduction pathway. It mediates pheromone signals acting between STE20 and STE11. It is absolutely required for pheromone-induced transcription of FUS1. May play a role in cell-cycle arrest in response to pheromone..
Protein Sequence MMETPTDNIVSPFHNFGSSTQYSGTLSRTPNQIIELEKPSTLSPLSRGKKWTEKLARFQRSSAKKKRFSPSPISSSTFSFSPKSRVTSSNSSGNEDGNLMNTPSTVSTDYLPQHPHRTSSLPRPNSNLFHASNSNLSRANEPPRAENLSDNIPPKVAPFGYPIQRTSIKKSFLNASCTLCDEPISNRRKGEKIIELACGHLSHQECLIISFGTTSKADVRALFPFCTKCKKDTNKAVQCIPENDELKDILISDFLIHKIPDSELSITPQSRFPPYSPLLPPFGLSYTPVERQTIYSQAPSLNPNLILAAPPKERNQIPQKKSNYTFLHSPLGHRRIPSGANSILADTSVALSANDSISAVSNSVRAKDDETKTTLPLLRSYFIQILLNNFQEELQDWRIDGDYGLLRLVDKLMISKDGQRYIQCWCFLFEDAFVIAEVDNDVDVLEIRLKNLEVFTPIANLRMTTLEASVLKCTLNKQHCADLSDLYIVQNINSDESTTVQKWISGILNQDFVFNEDNITSTLPILPIIKNFSKDVGNGRHETSTFLGLINPNKVVEVGNVHDNDTVIIRRGFTLNSGECSRQSTVDSIQSVLTTISSILSLKREKPDNLAIILQIDFTKLKEEDSLIVVYNSLKALTIKFARLQFCFVDRNNYVLDYGSVLHKIDSLDSISNLKSKSSSTQFSPIWLKNTLYPENIHEHLGIVAVSNSNMEAKKSILFQDYRCFTSFGRRRPNELKIKVGYLNVDYSDKIDELVEASSWTFVLETLCYSFGLSFDEHDDDDEEDNDDSTDNELDNSSGSLSDAESTTTIHIDSPFDNENATANMVNDRNLLTEGEHSNIENLETVASSVQPALIPNIRFSLHSEEEGTNENENENDMPVLLLSDMDKGIDGITRRSSFSSLIESGNNNCPLHMDYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MMETPTDNIVS
----CCCCCCCCCCC		17.3728889911
11PhosphorylationTPTDNIVSPFHNFGS
CCCCCCCCCCCCCCC		20.3228889911
29PhosphorylationYSGTLSRTPNQIIEL
CCCCCCCCCCCEEEE		24.1828889911
38AcetylationNQIIELEKPSTLSPL
CCEEEECCCCCCCCC		57.8224489116
40PhosphorylationIIELEKPSTLSPLSR
EEEECCCCCCCCCHH		53.7121440633
41PhosphorylationIELEKPSTLSPLSRG
EEECCCCCCCCCHHC		39.5228152593
43PhosphorylationLEKPSTLSPLSRGKK
ECCCCCCCCCHHCHH		24.7128152593
46PhosphorylationPSTLSPLSRGKKWTE
CCCCCCCHHCHHHHH		42.2321551504
69PhosphorylationSAKKKRFSPSPISSS
HCCCCCCCCCCCCCC		28.6219684113
71PhosphorylationKKKRFSPSPISSSTF
CCCCCCCCCCCCCCE		33.4019684113
74PhosphorylationRFSPSPISSSTFSFS
CCCCCCCCCCCEECC		22.9421440633
75PhosphorylationFSPSPISSSTFSFSP
CCCCCCCCCCEECCC		33.8319823750
76PhosphorylationSPSPISSSTFSFSPK
CCCCCCCCCEECCCC		27.0421440633
77PhosphorylationPSPISSSTFSFSPKS
CCCCCCCCEECCCCC		25.8321440633
79PhosphorylationPISSSTFSFSPKSRV
CCCCCCEECCCCCCC		25.5519684113
81PhosphorylationSSSTFSFSPKSRVTS
CCCCEECCCCCCCCC		30.1619684113
83UbiquitinationSTFSFSPKSRVTSSN
CCEECCCCCCCCCCC		50.0917644757
92PhosphorylationRVTSSNSSGNEDGNL
CCCCCCCCCCCCCCC		50.3023749301
102PhosphorylationEDGNLMNTPSTVSTD
CCCCCCCCCCCCCCC		12.4928889911
120PhosphorylationQHPHRTSSLPRPNSN
CCCCCCCCCCCCCCC		41.6021082442
126PhosphorylationSSLPRPNSNLFHASN
CCCCCCCCCCCCCCC		37.2830377154
265PhosphorylationKIPDSELSITPQSRF
ECCCCCCCCCCCCCC		21.9929688323
267PhosphorylationPDSELSITPQSRFPP
CCCCCCCCCCCCCCC		16.3529688323
270PhosphorylationELSITPQSRFPPYSP
CCCCCCCCCCCCCCC		36.7729688323
287PhosphorylationPPFGLSYTPVERQTI
CCCCCCCCCCCCCCH		19.9216424299
329PhosphorylationSNYTFLHSPLGHRRI
CCCEECCCCCCCCCC		24.7817330950
338PhosphorylationLGHRRIPSGANSILA
CCCCCCCCCCCCEEC		48.4427017623
348PhosphorylationNSILADTSVALSAND
CCEECCCEEEECCCC		13.1221440633
356PhosphorylationVALSANDSISAVSNS
EEECCCCCHHHHHHC		20.4627017623
464PhosphorylationPIANLRMTTLEASVL
CCCCCCCHHHHHHHH		23.0722369663
465PhosphorylationIANLRMTTLEASVLK
CCCCCCHHHHHHHHH		17.1722369663
469PhosphorylationRMTTLEASVLKCTLN
CCHHHHHHHHHHHCC		20.7122369663
577PhosphorylationRRGFTLNSGECSRQS
ECCEEECCCCCCCCH		38.8021082442
677UbiquitinationSISNLKSKSSSTQFS
HHHCCCCCCCCCCCC		53.4117644757
689UbiquitinationQFSPIWLKNTLYPEN
CCCCEEECCCCCCCC		32.6517644757
845PhosphorylationSNIENLETVASSVQP
CCCCCHHHHHHHCCC		25.2530377154
861PhosphorylationLIPNIRFSLHSEEEG
HCCCEEEEECCCCCC		18.4728889911
894PhosphorylationDKGIDGITRRSSFSS
CCCCCCCCCCHHHHH		26.0919823750
897PhosphorylationIDGITRRSSFSSLIE
CCCCCCCHHHHHHHH		32.2321440633
898PhosphorylationDGITRRSSFSSLIES
CCCCCCHHHHHHHHC		27.6021440633
900PhosphorylationITRRSSFSSLIESGN
CCCCHHHHHHHHCCC		26.6121440633
901PhosphorylationTRRSSFSSLIESGNN
CCCHHHHHHHHCCCC		31.2120377248
905PhosphorylationSFSSLIESGNNNCPL
HHHHHHHCCCCCCCC		39.5719823750
916PhosphorylationNCPLHMDYI------
CCCCCCCCC------		10.8519795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCDC4P07834
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FUS3_YEASTFUS3physical
9501067
STE11_YEASTSTE11physical
9501067
GBB_YEASTSTE4physical
9501067
STE5_YEASTSTE5physical
9501067
STE7_YEASTSTE7physical
9501067
STE5_YEASTSTE5physical
12808050
FUS3_YEASTFUS3physical
12511654
STE11_YEASTSTE11physical
12511654
STE7_YEASTSTE7physical
12511654
STE5_YEASTSTE5physical
8943027
FUS3_YEASTFUS3physical
14734536
KSS1_YEASTKSS1physical
14734536
GBB_YEASTSTE4physical
7667635
FUS3_YEASTFUS3physical
8314085
FUS3_YEASTFUS3physical
8062390
KSS1_YEASTKSS1physical
8062390
STE11_YEASTSTE11physical
8062390
STE7_YEASTSTE7physical
8062390
FUS3_YEASTFUS3physical
8052657
STE11_YEASTSTE11physical
8052657
STE7_YEASTSTE7physical
8052657
FUS3_YEASTFUS3physical
7851759
STE11_YEASTSTE11physical
7851759
STE7_YEASTSTE7physical
7851759
STE11_YEASTSTE11physical
11071925
STE7_YEASTSTE7physical
11071925
FUS3_YEASTFUS3physical
11071925
STE5_YEASTSTE5physical
11071925
STE7_YEASTSTE7physical
9335587
STE7_YEASTSTE7physical
9311911
STE11_YEASTSTE11physical
9335587
STE11_YEASTSTE11physical
9311911
FUS3_YEASTFUS3physical
9335587
FUS3_YEASTFUS3physical
9311911
GBB_YEASTSTE4physical
9335587
GBB_YEASTSTE4physical
9311911
FUS3_YEASTFUS3physical
10593609
STE5_YEASTSTE5physical
10593609
GBB_YEASTSTE4physical
10481914
STE11_YEASTSTE11physical
10481914
STE7_YEASTSTE7physical
10481914
FUS3_YEASTFUS3physical
10481914
STE5_YEASTSTE5physical
10481914
STE7_YEASTSTE7physical
15456892
PMD1_YEASTPMD1physical
9636180
OKP1_YEASTOKP1physical
9636180
CDC24_YEASTCDC24physical
15657049
BEM1_YEASTBEM1physical
15657049
STT4_YEASTSTT4physical
16209942
NOT2_YEASTCDC36genetic
6757719
NOT1_YEASTCDC39genetic
6757719
NOT1_YEASTCDC39genetic
3037311
STE12_YEASTSTE12genetic
9286665
STE11_YEASTSTE11genetic
1628832
STE7_YEASTSTE7genetic
15713635
ODO2_YEASTKGD2physical
16554755
YEC3_YEASTYEL023Cphysical
16554755
STE5_YEASTSTE5physical
16847350
GBB_YEASTSTE4genetic
8722766
GBG_YEASTSTE18genetic
8722766
STE7_YEASTSTE7genetic
8524219
SST2_YEASTSST2genetic
8289786
STE11_YEASTSTE11physical
18077328
STE7_YEASTSTE7physical
18077328
FUS3_YEASTFUS3physical
18077328
STE7_YEASTSTE7physical
19303851
STE11_YEASTSTE11genetic
8722766
STE5_YEASTSTE5genetic
8722766
STE5_YEASTSTE5genetic
9311911
CG11_YEASTCLN1physical
21945277
CG12_YEASTCLN2physical
21945277
CGS5_YEASTCLB5physical
21945277
CG22_YEASTCLB2physical
21945277
FUS3_YEASTFUS3physical
21863494
STE11_YEASTSTE11physical
23242997
HOG1_YEASTHOG1genetic
9744864
STE50_YEASTSTE50physical
8816472
STE11_YEASTSTE11physical
8816472
STE7_YEASTSTE7physical
8816472
FUS3_YEASTFUS3physical
8816472
ERK1_CANALCEK1physical
23953117
FUS3_YEASTFUS3genetic
26179918
CG12_YEASTCLN2physical
25619768
CG12_YEASTCLN2physical
24909323
MSG5_YEASTMSG5genetic
26179917
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-898, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, AND MASSSPECTROMETRY.

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