STE7_YEAST - dbPTM
STE7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE7_YEAST
UniProt AC P06784
Protein Name Serine/threonine-protein kinase STE7
Gene Name STE7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 515
Subcellular Localization
Protein Description Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it is phosphorylated by the ste11 protein kinase and that it can phosphorylate the FUS3 and or KSS1 kinases..
Protein Sequence MFQRKTLQRRNLKGLNLNLHPDVGNNGQLQEKTETHQGQSRIEGHVMSNINAIQNNSNLFLRRGIKKKLTLDAFGDDQAISKPNTVVIQQPQNEPVLVLSSLSQSPCVSSSSSLSTPCIIDAYSNNFGLSPSSTNSTPSTIQGLSNIATPVENEHSISLPPLEESLSPAAADLKDTLSGTSNGNYIQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKFRHWCRKIKSKIKEDKRIKREALDRAKLEKKQSERSTH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
149PhosphorylationQGLSNIATPVENEHS
HCCCCCCCCCCCCCC		24.8728889911
204PhosphorylationIGAGNSGTVVKALHV
CCCCCCCCEEEEEEC		23.1927214570
359PhosphorylationVSKKLINSIADTFVG
CCHHHHHHHHHHCCC		16.508131746
363PhosphorylationLINSIADTFVGTSTY
HHHHHHHHCCCCCCC		15.938131746
471PhosphorylationDLIMKYVSPSKDDKF
HHHHHHCCCCCCHHH		21.9928889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
363TPhosphorylationKinaseSTE11P23561
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FUS3_YEASTFUS3physical
8668180
KSS1_YEASTKSS1physical
8668180
FUS3_YEASTFUS3physical
14734536
KSS1_YEASTKSS1physical
14734536
STE5_YEASTSTE5physical
7851759
FUS3_YEASTFUS3physical
7851759
KSS1_YEASTKSS1physical
7851759
FUS3_YEASTFUS3physical
11921098
KSS1_YEASTKSS1physical
11134045
FUS3_YEASTFUS3physical
11134045
STE5_YEASTSTE5physical
9335587
STE5_YEASTSTE5physical
10593609
FUS3_YEASTFUS3physical
15456892
FUS3_YEASTFUS3physical
8052657
FUS3_YEASTFUS3physical
8384702
FUS3_YEASTFUS3physical
8159759
OCH1_YEASTOCH1genetic
10535982
STE12_YEASTSTE12genetic
2193847
STE12_YEASTSTE12genetic
9286665
STE12_YEASTSTE12genetic
8259520
FUS3_YEASTFUS3physical
16364919
KSS1_YEASTKSS1physical
16364919
ASH1_YEASTASH1genetic
9566907
STE11_YEASTSTE11physical
17952059
STE5_YEASTSTE5physical
17952059
KSS1_YEASTKSS1physical
18077328
FUS3_YEASTFUS3physical
18077328
STE11_YEASTSTE11physical
18077328
STE7_YEASTSTE7physical
18077328
SNO4_YEASTSNO4physical
18467557
KSS1_YEASTKSS1physical
19303851
FUS3_YEASTFUS3physical
19303851
DSK2_YEASTDSK2physical
20489023
EBS1_YEASTEBS1physical
20489023
FUS3_YEASTFUS3physical
20489023
H3_YEASTHHT1physical
20489023
HRP1_YEASTHRP1physical
20489023
SP110_YEASTSPC110physical
20489023
SPC29_YEASTSPC29physical
20489023
KAPA_YEASTTPK1genetic
20421603
KAPC_YEASTTPK3genetic
20421603
FUS3_YEASTFUS3physical
21118957
KSS1_YEASTKSS1physical
21118957
NBP2_YEASTNBP2physical
21118957
STE5_YEASTSTE5physical
21118957
DIB1_YEASTDIB1physical
21460040
PFKA1_YEASTPFK1physical
21460040
MALX3_YEASTIMA1physical
21460040
YIG1_YEASTYIG1physical
21460040
STE5_YEASTSTE5physical
21628578
STE11_YEASTSTE11physical
8816472
STE5_YEASTSTE5physical
8816472
STE7_YEASTSTE7physical
8816472
FUS3_YEASTFUS3physical
8816472
FUS3_YEASTFUS3physical
23953117
PBS2_YEASTPBS2genetic
25356552
LSM1_YEASTLSM1genetic
26447709
PAT1_YEASTPAT1genetic
26447709
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Activation of MEK family kinases requires phosphorylation of twoconserved Ser/Thr residues.";
Zheng C.-F., Guan K.-L.;
EMBO J. 13:1123-1131(1994).
Cited for: PHOSPHORYLATION AT SER-359 AND THR-363, AND MUTAGENESIS.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-149, AND MASSSPECTROMETRY.

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