| UniProt ID | KAPA_YEAST | |
|---|---|---|
| UniProt AC | P06244 | |
| Protein Name | cAMP-dependent protein kinase type 1 | |
| Gene Name | TPK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 397 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | ||
| Protein Sequence | MSTEEQNGGGQKSLDDRQGEESQKGETSERETTATESGNESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYGVQGEDPYADLFRDF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSTEEQNGG ------CCCCCCCCC | 44.52 | 22814378 | |
| 2 | Phosphorylation | ------MSTEEQNGG ------CCCCCCCCC | 44.52 | 27717283 | |
| 3 | Phosphorylation | -----MSTEEQNGGG -----CCCCCCCCCC | 42.09 | 27717283 | |
| 13 | Phosphorylation | QNGGGQKSLDDRQGE CCCCCCCCCCHHCCC | 29.19 | 22369663 | |
| 22 | Phosphorylation | DDRQGEESQKGETSE CHHCCCCCCCCCCCC | 32.65 | 20377248 | |
| 27 | Phosphorylation | EESQKGETSERETTA CCCCCCCCCCCCCCC | 44.55 | 21551504 | |
| 28 | Phosphorylation | ESQKGETSERETTAT CCCCCCCCCCCCCCC | 30.29 | 19823750 | |
| 32 | Phosphorylation | GETSERETTATESGN CCCCCCCCCCCCCCC | 28.14 | 28889911 | |
| 33 | Phosphorylation | ETSERETTATESGNE CCCCCCCCCCCCCCC | 27.16 | 19779198 | |
| 35 | Phosphorylation | SERETTATESGNESK CCCCCCCCCCCCCCC | 28.70 | 25521595 | |
| 37 | Phosphorylation | RETTATESGNESKSV CCCCCCCCCCCCCCC | 42.43 | 25521595 | |
| 41 | Phosphorylation | ATESGNESKSVEKEG CCCCCCCCCCCCCCC | 33.94 | 25752575 | |
| 43 | Phosphorylation | ESGNESKSVEKEGGE CCCCCCCCCCCCCCC | 44.80 | 28889911 | |
| 95 | Phosphorylation | QILRTLGTGSFGRVH HHHHEECCCCCCEEE | 32.53 | 22369663 | |
| 97 | Phosphorylation | LRTLGTGSFGRVHLI HHEECCCCCCEEEEE | 25.10 | 22369663 | |
| 212 | Ubiquitination | DIIYRDLKPENILLD CCCCCCCCHHHEEEC | 55.35 | 23749301 | |
| 234 | Phosphorylation | TDFGFAKYVPDVTYT CCCCHHCCCCCCEEE | 17.49 | 22369663 | |
| 239 | Phosphorylation | AKYVPDVTYTLCGTP HCCCCCCEEEECCCC | 20.40 | 22369663 | |
| 240 | Phosphorylation | KYVPDVTYTLCGTPD CCCCCCEEEECCCCC | 9.50 | 20377248 | |
| 241 | Phosphorylation | YVPDVTYTLCGTPDY CCCCCEEEECCCCCC | 13.25 | 22369663 | |
| 245 | Phosphorylation | VTYTLCGTPDYIAPE CEEEECCCCCCCCCC | 16.40 | 22369663 | |
| 348 | Acetylation | FKEVVWEKLLSRNIE HHHHHHHHHHHCCCC | 38.73 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KAPA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KAPA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KAPA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-239; TYR-240 ANDTHR-241, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-241, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-241, AND MASSSPECTROMETRY. | |
