dbPTM

RRAAH_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRAAH_YEAST
UniProt AC	P40011
Protein Name	4-hydroxy-4-methyl-2-oxoglutarate aldolase
Gene Name	YER010C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	234
Subcellular Localization
Protein Description	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions..
Protein Sequence	MSDLQKLQRFSTCDISDGLLNVYNIPTGGYFPNLTAISPPQNSSIVGTAYTVLFAPIDDPRPAVNYIDSVPPNSILVLALEPHLQSQFHPFIKITQAMYGGLMSTRAQYLKSNGTVVFGRIRDVDEHRTLNHPVFAYGVGSCAPKAVVKAVGTNVQLKILTSDGVTQTICPGDYIAGDNNGIVRIPVQETDISKLVTYIEKSIEVDLLVSEDIKNGIPAKQAQNDRRSVLKKYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Acetylation	------MSDLQKLQR ------CCHHHHHHH	22814378
95	Phosphorylation	FHPFIKITQAMYGGL CCHHHHHHHHHHCCH	27017623
99	Phosphorylation	IKITQAMYGGLMSTR HHHHHHHHCCHHHHH	27017623
109	Phosphorylation	LMSTRAQYLKSNGTV HHHHHHHHHHHCCEE	27017623
193	Phosphorylation	PVQETDISKLVTYIE ECCHHCHHHHHHHHH	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRAAH_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRAAH_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRAAH_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRAAH_YEAST	YER010C	physical	18719252
CSN12_YEAST	YJR084W	genetic	27708008
MAK16_YEAST	MAK16	genetic	27708008
TAF5_YEAST	TAF5	genetic	27708008
TRS20_YEAST	TRS20	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
UTP5_YEAST	UTP5	genetic	27708008
KRE9_YEAST	KRE9	genetic	27708008
BET3_YEAST	BET3	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
NIP7_YEAST	NIP7	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
RS29B_YEAST	RPS29B	genetic	27708008
UFD2_YEAST	UFD2	genetic	27708008
RAD57_YEAST	RAD57	genetic	27708008
BAP3_YEAST	BAP3	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
PLP1_YEAST	PLP1	genetic	27708008
HNT2_YEAST	HNT2	genetic	27708008
SUM1_YEAST	SUM1	genetic	27708008
ASPG1_YEAST	ASP1	genetic	27708008
PEX3_YEAST	PEX3	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
FLX1_YEAST	FLX1	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
SNX4_YEAST	SNX4	genetic	27708008
ILM1_YEAST	ILM1	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
OCA1_YEAST	OCA1	genetic	27708008
CYB5_YEAST	CYB5	genetic	27708008
SFL1_YEAST	SFL1	genetic	27708008
PMT3_YEAST	PMT3	genetic	27708008
CHL1_YEAST	CHL1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRAAH_YEAST

Related Literatures of Post-Translational Modification