| UniProt ID | CHL1_YEAST | |
|---|---|---|
| UniProt AC | P22516 | |
| Protein Name | ATP-dependent DNA helicase CHL1 | |
| Gene Name | CHL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 861 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. [PubMed: 10931920 May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres] | |
| Protein Sequence | MDKKEYSETFYHPYKPYDIQVQLMETVYRVLSEGKKIAILESPTGTGKTLSLICATMTWLRMNKADIFTRMETNIKTNEDDSENLSDDEPDWVIDTYRKSVLQEKVDLLNDYEKHLNEINTTSCKQLKTMCDLDKEHGRYKSVDPLRKKRKGARHLDVSLEEQDFIPRPYESDSENNDTSKSTRGGRISDKDYKLSELNSQIITLLDKIDGKVSRDPNNGDRFDVTNQNPVKIYYASRTYSQLGQFTSQLRLPSFPSSFRDKVPDEKVKYLPLASKKQLCINPKVMKWKTLEAINDACADLRHSKEGCIFYQNTNEWRHCPDTLALRDMIFSEIQDIEDLVPLGKSLGICPYYASREALPIAEVVTLPYQYLLSESTRSSLQINLENSIVIIDEAHNLIETINSIYSSQISLEDLKNCHKGIVTYFNKFKSRLNPGNRVNLLKLNSLLMTLIQFIVKNFKKIGQEIDPNDMFTGSNIDTLNIHKLLRYIKVSKIAYKIDTYNQALKEEESSKNENPIKETHKKSVSSQPLLFKVSQFLYCLTNLTSEGQFFFEKNYSIKYMLLEPSKPFESILNQAKCVVLAGGTMEPMSEFLSNLLPEVPSEDITTLSCNHVIPKENLQTYITNQPELEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGIVAFFPSYQYLAHVIQCWKQNDRFATLNNVRKIFYEAKDGDDILSGYSDSVAEGRGSLLLAIVGGKLSEGINFQDDLCRAVVMVGLPFPNIFSGELIVKRKHLAAKIMKSGGTEEEASRATKEFMENICMKAVNQSVGRAIRHANDYANIYLLDVRYNRPNFRKKLSRWVQDSINSEHTTHQVISSTRKFFSMRSLNSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Phosphorylation | TLSLICATMTWLRMN HHHHHHHHHHHHHHC | 15.66 | 28889911 | |
| 58 | Phosphorylation | SLICATMTWLRMNKA HHHHHHHHHHHHCHH | 19.59 | 28889911 | |
| 77 | Phosphorylation | RMETNIKTNEDDSEN HHHHCCCCCCCCCCC | 39.79 | 29136822 | |
| 82 | Phosphorylation | IKTNEDDSENLSDDE CCCCCCCCCCCCCCC | 40.48 | 29136822 | |
| 86 | Phosphorylation | EDDSENLSDDEPDWV CCCCCCCCCCCCCCH | 55.38 | 20377248 | |
| 170 | Phosphorylation | QDFIPRPYESDSENN CCCCCCCCCCCCCCC | 29.37 | 19779198 | |
| 172 | Phosphorylation | FIPRPYESDSENNDT CCCCCCCCCCCCCCC | 40.36 | 28889911 | |
| 174 | Phosphorylation | PRPYESDSENNDTSK CCCCCCCCCCCCCCC | 52.05 | 21440633 | |
| 179 | Phosphorylation | SDSENNDTSKSTRGG CCCCCCCCCCCCCCC | 39.93 | 26447709 | |
| 180 | Phosphorylation | DSENNDTSKSTRGGR CCCCCCCCCCCCCCC | 27.72 | 26447709 | |
| 226 | Phosphorylation | NGDRFDVTNQNPVKI CCCCCCCCCCCCCEE | 32.69 | 27214570 | |
| 352 | Phosphorylation | KSLGICPYYASREAL HHHCCCCHHCCCCCC | 13.78 | 28889911 | |
| 353 | Phosphorylation | SLGICPYYASREALP HHCCCCHHCCCCCCC | 5.35 | 28889911 | |
| 355 | Phosphorylation | GICPYYASREALPIA CCCCHHCCCCCCCHH | 17.96 | 28889911 | |
| 501 | Phosphorylation | IAYKIDTYNQALKEE HHHHHHHHHHHHHHH | 11.09 | 28889911 | |
| 638 | Phosphorylation | FTFEKRMSPSLVNNH EEEEECCCHHHHHCH | 18.50 | 28889911 | |
| 654 | Phosphorylation | FQFFVDLSKAVPKKG HHHHHCHHHHCCCCC | 17.69 | 28889911 | |
| 848 | Phosphorylation | TTHQVISSTRKFFSM CHHHHHHHHHHHHHH | 22.55 | 27017623 | |
| 849 | Phosphorylation | THQVISSTRKFFSMR HHHHHHHHHHHHHHH | 30.96 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHL1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHL1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHL1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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