HEMH_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEMH_YEAST
• UniProt AC: P16622
• Protein Name: Ferrochelatase, mitochondrial
• Gene Name: HEM15
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 393
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. It is bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane.
• Protein Description: Catalyzes the ferrous insertion into protoporphyrin IX..
• Protein Sequence: MLSRTIRTQGSFLRRSQLTITRSFSVTFNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGPKVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFKRCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPLDFALGKSNDPVKDLSLVFGNHEST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Acetylation	KYQKTIAKYIAKFRT HHHHHHHHHHHHHCC	33.08	22865919
95	Phosphorylation	TPKIEKQYREIGGGS CHHHHHHHHHHCCCC	22.68	21440633
102	Phosphorylation	YREIGGGSPIRKWSE HHHHCCCCCCCCCCH	22.04	22369663
121	Acetylation	EVCKILDKTCPETAP HHHHHHHCCCCCCCC	48.89	24489116
130	Acetylation	CPETAPHKPYVAFRY CCCCCCCCCEEEEEC	36.66	24489116
147	Acetylation	PLTAETYKQMLKDGV CCCHHHHHHHHHHHH	36.33	24489116
207	Acetylation	PTNEGLIKAFSENIT CCCHHHHHHHHHHHH	48.71	24489116
354	Ubiquitination	EGMADLVKSHLQSNQ HHHHHHHHHHHHHCC	39.18	17644757
375	Ubiquitination	PLDFALGKSNDPVKD CCHHHCCCCCCCCCC	47.11	17644757
381	Acetylation	GKSNDPVKDLSLVFG CCCCCCCCCHHHEEC	59.34	24489116
393	Phosphorylation	VFGNHEST------- EECCCCCC-------	39.38	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEMH_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEMH_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEMH_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HEMH_YEAST	HEM15	physical	11831847
NCE2_YEAST	NCE102	genetic	27317660
KCC2B_HUMAN	CAMK2B	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, AND MASSSPECTROMETRY.
PubMed: 17563356