| UniProt ID | NMD3_YEAST | |
|---|---|---|
| UniProt AC | P38861 | |
| Protein Name | 60S ribosomal export protein NMD3 | |
| Gene Name | NMD3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 518 | |
| Subcellular Localization | Cytoplasm . Nucleus, nucleoplasm . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. | |
| Protein Description | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Unlikely to play a significant role in nonsense-mediated mRNA decay (NMD).. | |
| Protein Sequence | MEFTPIDPHQHQNAATLLCCNCGTPIDGSTGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTISISEAKDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEIVPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNALADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDSVMGYFIANSNYNSDLFDGLNIDYVPDVVLVKKLYQRKSKKSRHWKLKRMAKEHKDIDASLDYNSRAQKQEMERAEKDYELFLQELEEDAELRQSVNLYKNREANVPPEEHEMDEDEDEDAPQINIDELLDELDEMTLEDGVENTPVESQQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 187 | Phosphorylation | KHNAHVDTISISEAK HCCCCCEEEEHHHHC | 18.61 | 28889911 | |
| 189 | Phosphorylation | NAHVDTISISEAKDG CCCCEEEEHHHHCCC | 23.35 | 28889911 | |
| 191 | Phosphorylation | HVDTISISEAKDGLD CCEEEEHHHHCCCCC | 25.39 | 24961812 | |
| 201 | Phosphorylation | KDGLDFFYAQKNHAV CCCCCEEEECCCCHH | 14.23 | 28889911 | |
| 204 | Acetylation | LDFFYAQKNHAVKMI CCEEEECCCCHHHHH | 42.39 | 24489116 | |
| 422 | Acetylation | KRMAKEHKDIDASLD HHHHHHHCCCCHHCC | 58.43 | 24489116 | |
| 427 | Phosphorylation | EHKDIDASLDYNSRA HHCCCCHHCCCCHHH | 20.30 | 27214570 | |
| 446 | Phosphorylation | MERAEKDYELFLQEL HHHHHHHHHHHHHHH | 26.12 | 19779198 | |
| 462 | Phosphorylation | EDAELRQSVNLYKNR HHHHHHHHHHCHHCC | 13.41 | 19779198 | |
| 467 | Ubiquitination | RQSVNLYKNREANVP HHHHHCHHCCCCCCC | 53.33 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NMD3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NMD3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NMD3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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