NIC96_YEAST - dbPTM
NIC96_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NIC96_YEAST
UniProt AC P34077
Protein Name Nucleoporin NIC96
Gene Name NIC96
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 839
Subcellular Localization Nucleus, nuclear pore complex. Nucleus membrane
Peripheral membrane protein
Cytoplasmic side. Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side. Symmetric distribution.
Protein Description Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NIC96, which is localized to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import..
Protein Sequence MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKNKASKDYTKAHYLLANSGLSFEDVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFGILIQDKKTVDHKKSISSLDPKLPSWGNKGNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFISILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLATNVNKIKSFIDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQTLLLSGLYGLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILANYTKSFRYSDPRVAVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQPLLHVRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSLLSDTLSASDLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNISSIRELYFNKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILNESKYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLETLRGNKLH
----CCCCCCCCCCC		20.1419795423
166AcetylationFGILIQDKKTVDHKK
HCEEEECCCCCCCCH		33.6924489116
174PhosphorylationKTVDHKKSISSLDPK
CCCCCCHHHHHCCCC		32.2928152593
176PhosphorylationVDHKKSISSLDPKLP
CCCCHHHHHCCCCCC		31.7521440633
177PhosphorylationDHKKSISSLDPKLPS
CCCHHHHHCCCCCCC		34.8124961812
181AcetylationSISSLDPKLPSWGNK
HHHHCCCCCCCCCCC		73.1024489116
195PhosphorylationKGNNILNSNESRLNV
CCCCCCCCCCHHCCC		38.2330377154
198PhosphorylationNILNSNESRLNVNEN
CCCCCCCHHCCCCCC		46.4421440633
266AcetylationILESMKSKDINIVEV
HHHHHHCCCCCEEHH		58.0524489116
366PhosphorylationNIKKVEQSFLTYFKA
CHHHHHHHHHHHHHH		14.5521551504
376PhosphorylationTYFKAYASSKDHGLP
HHHHHHHCCCCCCCC		25.8321551504
378AcetylationFKAYASSKDHGLPVE
HHHHHCCCCCCCCCE		51.7724489116
541PhosphorylationFANILANYTKSFRYS
HHHHHHHHHCCCCCC		15.2227017623
542PhosphorylationANILANYTKSFRYSD
HHHHHHHHCCCCCCC		21.7327017623
543AcetylationNILANYTKSFRYSDP
HHHHHHHCCCCCCCH		36.9224489116
807AcetylationGQQIDSLKNVARQCM
CHHHHHHHHHHHHHH		54.0224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NIC96_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NIC96_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NIC96_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUP53_YEASTNUP53physical
10688190
COG2_YEASTCOG2physical
10688190
MLP2_YEASTMLP2physical
10617624
NUP49_YEASTNUP49physical
10617624
NUP57_YEASTNUP57physical
10617624
NU192_YEASTNUP192physical
10428845
NUP53_YEASTNUP53physical
11071914
NUP53_YEASTNUP53physical
12496130
NUP53_YEASTNUP53physical
14697200
NUP57_YEASTNUP57physical
14697200
NUP49_YEASTNUP49physical
14697200
SNL1_YEASTSNL1genetic
9450961
NSP1_YEASTNSP1physical
16429126
NU192_YEASTNUP192physical
16429126
NUP57_YEASTNUP57physical
16429126
HSP72_YEASTSSA2physical
16429126
NUP57_YEASTNUP57physical
15741174
NUP49_YEASTNUP49physical
15741174
NSP1_YEASTNSP1physical
15741174
IMB4_YEASTKAP123physical
15741174
IMB1_YEASTKAP95physical
17897934
NDC1_YEASTNDC1physical
18467557
NUP49_YEASTNUP49physical
18467557
NUP2_YEASTNUP2physical
18467557
ECM1_YEASTECM1genetic
20093466
NUP60_YEASTNUP60genetic
20093466
PER1_YEASTPER1genetic
20093466
THRC_YEASTTHR4genetic
20093466
VAM6_YEASTVAM6genetic
20093466
RXT3_YEASTRXT3genetic
20093466
TPS2_YEASTTPS2genetic
20093466
ARX1_YEASTARX1genetic
20093466
SAC3_YEASTSAC3genetic
20093466
NUP42_YEASTNUP42genetic
20093466
RT103_YEASTRTT103genetic
20093466
SSD1_YEASTSSD1genetic
20093466
SLX9_YEASTSLX9genetic
20093466
NEM1_YEASTNEM1genetic
20093466
MOG1_YEASTMOG1genetic
20093466
FRMSR_YEASTYKL069Wgenetic
20093466
MRT4_YEASTMRT4genetic
20093466
NU133_YEASTNUP133genetic
20093466
POM34_YEASTPOM34genetic
20093466
LIPB_YEASTLIP2genetic
20093466
YPT6_YEASTYPT6genetic
20093466
YL287_YEASTYLR287Cgenetic
20093466
NUP2_YEASTNUP2genetic
20093466
CDC73_YEASTCDC73genetic
20093466
NU188_YEASTNUP188genetic
20093466
SAM37_YEASTSAM37genetic
20093466
PO152_YEASTPOM152genetic
20093466
ESC1_YEASTESC1genetic
20093466
AF9_YEASTYAF9genetic
20093466
PHO80_YEASTPHO80genetic
20093466
BUB3_YEASTBUB3genetic
20093466
ISR1_YEASTISR1genetic
20093466
KAR3_YEASTKAR3genetic
20093466
NSP1_YEASTNSP1physical
18206968
NUP57_YEASTNUP57physical
18206968
NUP49_YEASTNUP49physical
18206968
NU188_YEASTNUP188genetic
18206968
NSP1_YEASTNSP1physical
18046405
NUP57_YEASTNUP57physical
18046405
NUP49_YEASTNUP49physical
18046405
NU192_YEASTNUP192physical
18046405
SPR3_YEASTSPR3physical
22875988
SYV_YEASTVAS1physical
22875988
YG3A_YEASTYGR130Cphysical
22875988
BLI1_YEASTBLI1physical
22875988
RNA1_YEASTRNA1physical
22875988
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NIC96_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, AND MASSSPECTROMETRY.

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