ECM1_YEAST - dbPTM
ECM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ECM1_YEAST
UniProt AC P39715
Protein Name Shuttling pre-60S factor ECM1
Gene Name ECM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 212
Subcellular Localization Nucleus, nucleolus. Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm and is re-imported by the KAP123 karyopherin.
Protein Description Pre-ribosomal factor involved in 60S ribosomal protein subunit export from the nucleus..
Protein Sequence MWEQRRQKVVFSLTILVRYRLKQSMAKKISKNSRAARQSDALEPEVKDLSELPRAEKTDLTNILIRTAAKNEALLEAKISKKANKSKRGKKLNKKALEDKLANSISSMDRDRLVKALNFTNRLDGKIAKSISRAKYIQNTRKAGWDSTNETIKKELAFLNGGLSVQAKSASEGNAEKEDEEIPEVFDSLAEDNTVQKTPTNRFGVLPDDVEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationAKKISKNSRAARQSD
HHHHHHCHHHHHHHH		27.3419823750
39PhosphorylationNSRAARQSDALEPEV
CHHHHHHHHCCCHHH		21.2121440633
57AcetylationSELPRAEKTDLTNIL
HHCCCCCCCCHHHHH		46.4822865919
70AcetylationILIRTAAKNEALLEA
HHHHHHHHCHHHHHH		53.5122865919
104PhosphorylationLEDKLANSISSMDRD
HHHHHHHHHHHCCHH		20.4530377154
106PhosphorylationDKLANSISSMDRDRL
HHHHHHHHHCCHHHH		21.3030377154
107PhosphorylationKLANSISSMDRDRLV
HHHHHHHHCCHHHHH		24.0430377154
115AcetylationMDRDRLVKALNFTNR
CCHHHHHHHHHHHHC		52.3125381059
126AcetylationFTNRLDGKIAKSISR
HHHCCCHHHHHHHHH		38.8725381059
129AcetylationRLDGKIAKSISRAKY
CCCHHHHHHHHHHHH		52.3625381059
135AcetylationAKSISRAKYIQNTRK
HHHHHHHHHHHHHHH		41.6025381059
147PhosphorylationTRKAGWDSTNETIKK
HHHCCCCCCCHHHHH		26.9921440633
148PhosphorylationRKAGWDSTNETIKKE
HHCCCCCCCHHHHHH		34.3027717283
151PhosphorylationGWDSTNETIKKELAF
CCCCCCHHHHHHHHH		39.9227717283
164PhosphorylationAFLNGGLSVQAKSAS
HHHCCCEEEEEECCC		18.5630377154
169PhosphorylationGLSVQAKSASEGNAE
CEEEEEECCCCCCCC		39.7919779198
171PhosphorylationSVQAKSASEGNAEKE
EEEEECCCCCCCCCC		53.8021440633
177AcetylationASEGNAEKEDEEIPE
CCCCCCCCCHHCHHH		68.9724489116
188PhosphorylationEIPEVFDSLAEDNTV
CHHHHHHHHHCCCCC		20.2917563356
194PhosphorylationDSLAEDNTVQKTPTN
HHHHCCCCCCCCCCC		36.3128132839
198PhosphorylationEDNTVQKTPTNRFGV
CCCCCCCCCCCCCCC		20.4628132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ECM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ECM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ECM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUG1_YEASTNUG1genetic
11583615
RL2A_YEASTRPL2Agenetic
11583615
RL2B_YEASTRPL2Agenetic
11583615
ADH1_YEASTADH1physical
11805826
GCN1_YEASTGCN1physical
11805826
HSC82_YEASTHSC82physical
11805826
IMB4_YEASTKAP123physical
11805826
LYS2_YEASTLYS2physical
11805826
IMB3_YEASTPSE1physical
11805826
SXM1_YEASTSXM1physical
11805826
CDC6_YEASTCDC6physical
11678331
ECM1_YEASTECM1physical
11678331
YM11_YEASTEPO1physical
16554755
POM34_YEASTPOM34genetic
19061648
RIC1_YEASTRIC1genetic
19061648
EFGM_YEASTMEF1genetic
19061648
NUP59_YEASTASM4genetic
19061648
NU170_YEASTNUP170genetic
19061648
XRN1_YEASTXRN1genetic
19061648
MOG1_YEASTMOG1genetic
19061648
NU120_YEASTNUP120genetic
19061648
APQ12_YEASTAPQ12genetic
19061648
NU188_YEASTNUP188genetic
19061648
PO152_YEASTPOM152genetic
19061648
PUF4_YEASTPUF4genetic
19061648
MRT4_YEASTMRT4genetic
19061648
NM111_YEASTNMA111genetic
18408161
NUP42_YEASTNUP42genetic
18408161
POM34_YEASTPOM34genetic
18408161
MRX4_YEASTYPL168Wgenetic
18408161
NUP53_YEASTNUP53genetic
18408161
PO152_YEASTPOM152genetic
18408161
ERT1_YEASTERT1genetic
20093466
THI2_YEASTTHI2genetic
20093466
FRM2_YEASTFRM2genetic
20093466
YCV1_YEASTYCR061Wgenetic
20093466
ARX1_YEASTARX1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
RL29_YEASTRPL29genetic
20093466
ATG1_YEASTATG1genetic
20093466
MOG1_YEASTMOG1genetic
20093466
POM34_YEASTPOM34genetic
20093466
NOG1_YEASTNOG1physical
20348449
NOG2_YEASTNOG2physical
20348449
RLP24_YEASTRLP24physical
20348449
MRT4_YEASTMRT4physical
20348449
RL5_YEASTRPL5physical
20348449
IMB3_YEASTPSE1physical
20348449
SXM1_YEASTSXM1physical
20348449
FKBP_YEASTFPR1physical
20348449
YPR08_YEASTYPR108W-Aphysical
20348449
NU192_YEASTNUP192physical
20348449
MEX67_YEASTMEX67genetic
20348449
MTR2_YEASTMTR2genetic
20348449
NMD3_YEASTNMD3genetic
20348449
FIG1_YEASTFIG1genetic
21252230
ATG1_YEASTATG1genetic
22282571
CSN12_YEASTYJR084Wgenetic
27708008
NU145_YEASTNUP145genetic
27708008
RCC1_YEASTSRM1genetic
27708008
NU159_YEASTNUP159genetic
27708008
SEN1_YEASTSEN1genetic
27708008
MEX67_YEASTMEX67genetic
27708008
NU170_YEASTNUP170genetic
27708008
ERT1_YEASTERT1genetic
27708008
THI2_YEASTTHI2genetic
27708008
FRM2_YEASTFRM2genetic
27708008
ARX1_YEASTARX1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ATG1_YEASTATG1genetic
27708008
ASK10_YEASTASK10genetic
27708008
MOG1_YEASTMOG1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
POM34_YEASTPOM34genetic
27708008
EFM6_YEASTYNL024Cgenetic
27708008
YP096_YEASTYPR096Cgenetic
27708008
ASK1_YEASTASK1genetic
29674565
BUD31_YEASTBUD31genetic
29674565
ARX1_YEASTARX1genetic
29674565
TCPZ_YEASTCCT6genetic
29674565
NU145_YEASTNUP145genetic
29674565
APQ12_YEASTAPQ12genetic
29674565
RPA34_YEASTRPA34genetic
29674565
MOG1_YEASTMOG1genetic
29674565
FRMSR_YEASTYKL069Wgenetic
29674565
GSP1_YEASTGSP1genetic
29674565
NU188_YEASTNUP188genetic
29674565
NUP53_YEASTNUP53genetic
29674565
TTL_YEASTPBY1genetic
29674565
YMW4_YEASTYMR074Cgenetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ECM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, AND MASSSPECTROMETRY.

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