SXM1_YEAST - dbPTM
SXM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SXM1_YEAST
UniProt AC Q04175
Protein Name Importin beta SMX1
Gene Name SXM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 944
Subcellular Localization Cytoplasm. Nucleus, nuclear pore complex.
Protein Description Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity..
Protein Sequence MVQEQAILSCIEQTMVADAKIIKEAEQQLFEFQKQPGFTSFLLNIVSDDNFALNVRLSSAIYLKNKIHRSWDTKREDGIKADEKLSIKERLIETLVKNCENNHIRPILTETINGILVGQEDWDLAPIIKNLLSSGDASYIYPGLLLLFQLCKAHRWDMVGSRDYIDSVIEELFPIVEGIASNIGSQTDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMSWVQLHLYLCSKPLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDINMAFKEEGALRTLSNLFSFIDEPSVLENIFGHFIVPLLSQDKYMFLVARSLETIALYSEEFKDMNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQTYVQPLLEILSAKLESEVDYDIEHVMQILMYFALSMRDIPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKPIETLQIMENEGFTINFFTNWFNEKFYSVFAIKLQVLVILTLLKMPEVPNSVSPLLNNLTNKLVELTLSLPKAIRNRDAVTEGKSLEGDLTPEEEEEYFIECDDDMKETVLDQINVFQEVHTFFKNLQNEDAGKYEKIINYLDESKRDSLQVILEFVSQH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23UbiquitinationVADAKIIKEAEQQLF
HHCHHHHHHHHHHHH		55.1124961812
86PhosphorylationIKADEKLSIKERLIE
CCCCHHCCHHHHHHH		42.5628889911
222PhosphorylationSQPERIMSWVQLHLY
CCHHHHHHHHHHHHH		23.0230377154
229PhosphorylationSWVQLHLYLCSKPLP
HHHHHHHHHHCCCCC		8.5630377154
257AcetylationDKRVKVNKWGFGNLN
HHCCCCCCCCCCHHH		52.2424489116
401AcetylationIGSKRPEKLNNILPF
ECCCCHHHHHCHHHH		60.2324489116
865PhosphorylationIRNRDAVTEGKSLEG
HHCCCCCCCCCCCCC		40.5228889911
869PhosphorylationDAVTEGKSLEGDLTP
CCCCCCCCCCCCCCH		42.3725521595
875PhosphorylationKSLEGDLTPEEEEEY
CCCCCCCCHHHHHHH		33.1320377248
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SXM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SXM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SXM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ECM1_YEASTECM1physical
11805837
LHP1_YEASTLHP1physical
11805837
YD132_YEASTYDR132Cphysical
10688190
NBA1_YEASTNBA1physical
10688190
LHP1_YEASTLHP1physical
9817748
LHP1_YEASTLHP1physical
9412461
RL25_YEASTRPL25physical
9412461
RL31A_YEASTRPL31Aphysical
9412461
NU159_YEASTNUP159physical
9412461
NUP1_YEASTNUP1physical
9412461
NSP1_YEASTNSP1physical
9412461
RL16B_YEASTRPL16Bphysical
9412461
RL11A_YEASTRPL11Aphysical
16429126
RL16B_YEASTRPL16Bphysical
16429126
LHP1_YEASTLHP1physical
16429126
RL1D1_YEASTUTP30physical
16429126
PABP_YEASTPAB1physical
15769879
ASR1_YEASTASR1physical
17485461
UBI4P_YEASTUBI4genetic
19061648
CDC73_YEASTCDC73genetic
19061648
UTP4_YEASTUTP4genetic
19061648
SEM1_YEASTSEM1genetic
19061648
PAP2_YEASTPAP2genetic
19061648
SAP30_YEASTSAP30genetic
19061648
LSM7_YEASTLSM7genetic
19061648
BRR1_YEASTBRR1genetic
19061648
IMB4_YEASTKAP123genetic
19061648
PRP11_YEASTPRP11genetic
19061648
RLI1_YEASTRLI1genetic
19061648
ERF3_YEASTSUP35genetic
19061648
NGR1_YEASTNGR1genetic
19061648
SLX9_YEASTSLX9genetic
19061648
LTV1_YEASTLTV1genetic
19061648
NU159_YEASTNUP159genetic
19061648
PP12_YEASTGLC7genetic
19061648
SSB1_YEASTSSB1physical
19536198
NAP1_YEASTNAP1physical
18086883
GEM1_YEASTGEM1genetic
27708008
SCS22_YEASTSCS22genetic
27708008
H3_YEASTHHT1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
SNT1_YEASTSNT1genetic
27708008
OST4_YEASTOST4genetic
27708008
MFG1_YEASTMFG1genetic
27708008
TGL2_YEASTTGL2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
TRS85_YEASTTRS85genetic
27708008
RM01_YEASTMRPL1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
SLT2_YEASTSLT2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
HOS4_YEASTHOS4genetic
27708008
DAL81_YEASTDAL81genetic
27708008
BCK1_YEASTBCK1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
NU133_YEASTNUP133genetic
27708008
FPS1_YEASTFPS1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
PIG1_YEASTPIG1genetic
27708008
ERG6_YEASTERG6genetic
27708008
PRM6_YEASTPRM6genetic
27708008
MSC1_YEASTMSC1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
ADH1_YEASTADH1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
EAF3_YEASTEAF3genetic
27708008
BRR1_YEASTBRR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SXM1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-865 AND SER-869, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory